exam 1 drugs

Question 1

irbesartan/Avapro

Answer 1

antihypertensive: lowers diastolic BP

Ex. of graded response

Question 2

procainamide/Pronestyl

Answer 2

suppresses arrythmias

Ex of quantal response

Question 3

digoxin/Lanoxin

Answer 3

cardiac glycosides

blocks Na+/K+ ATPase for patient w/ heart failure

Question 4

Cocaine

Answer 4

blocks reuptake of DA at dopaminergic nerve terminals

Question 5

cyclosporin

Answer 5

blocks the drug efflux pump P-glycoprotein, which is in volved in multidrug reistance

Question 6

colchicine

Answer 6

Gout
binds tubulin & prevents microtubule polymerization
Ex. that effects structural proteins

Question 7

lithium

Answer 7

antidepressant

interferes w/ breakdown of IP, termination of IP3

Question 8

isoproterenol

Answer 8

beta agonist

Ex. of internalization of receptor

Question 9

trastuzumab/Herceptin

Answer 9

monoclonal antibody
binds HER2 & induces tumor regression in metastatic breast tumors
stops dimerization, stops MAPK

Question 10

cetuximab/Erbitux

Answer 10

monoclonal antibody
used in metastatic colon cancer
EX hat targets EGF receptor

Question 11

panitumumab/Vectibix

Answer 11

monoclonal antibody
used in metastatic colon cancer
EX hat targets EGF receptor

Question 12

gefitnib/Iressa

Answer 12

Tyrosine kinase inhibitor

blocks ATP binding site of kinase

Question 13

eriotinb/Tarceva

Answer 13

tyrosine kinase inhibitor

blocks ATP binding site of kinase

Question 14

Curare derivatives

Answer 14

anesthesia to cause muscle relaxation

Ex. of nicotinic receptor drugs

Question 15

CNS drugs

Answer 15

target the ganglion for antihypertensive effect

Ex. of nictinic receptor drugs

Question 16

varenicline/Chantix

Answer 16

smoking cessation

targets CNS nicotinic receptors

Question 17

Benzodiazepine agonist

Answer 17

bind GABAa receptor & enhance effect (sedation)

Question 18

Benzodiazepine antagonist

Answer 18

block BZ agonist action

Question 19

Benzodiazepine inverse agonist

Answer 19

negative allosteric modulator inhibits GABA (anxiety, seizures)

Question 20

lidocaine

Answer 20

antiarrhythmic

Na+ channel blocker (VG Channel)

Question 21

amlodipine

Answer 21

antihypertensive

Ca2+ channel antagonist (VG Channel) decrease muscular tone

Question 22

antidiabetic (sulfonurea of meglitinide)

Answer 22

block K+ channel & depolarization-> insulin secretion

Question 23

diazoxide/Hyperstat

Answer 23

severe hypertension

stimulate K+ channel

Question 24

dexamethasone

Answer 24

synthetic glucocorticoid

anti-inflammatory agent

Question 25

prednisone

Answer 25

glucocorticoid | transplant rejection

Question 26

spironolactone

Answer 26

mineralcorticoid | antagonist used in liver disease & mineralocorticoid excess

Question 27

tamoxifen/Nolvadex

Answer 27

estrogen antagonist | breast cancer therapy

Question 28

mifepristone

Answer 28

estrogen antagonist | used for abortion

Question 29

thiazolidinedione (glitazones)

Answer 29

used in typer II diabetes act on PPAR-gamma to sensitize cell to insulin

Question 30

ritonavir/Norvir

Answer 30

HIV protease

Question 31

Aspirin

Answer 31

anti-inflammatory | COX inhibitor

Question 32

penicillin

Answer 32

antibiotic | bacterial glycopeptide transpeptidase

Question 33

vinorelbine

Answer 33

target microtubles to inhibit STAT 3 phosphorylation in breast cancer

Question 34

cucumin

Answer 34

pancreatic cancer

Question 35

cyclopremide

Answer 35

hedgehog pathway blocker

Question 36

vismodegib/Erivedge

Answer 36

selective hedgehog pathway inhibitor

Question 37

Pravastatin

Answer 37

suppresses ING-gamma decreasing STAT1 activation

Question 38

Berbamine

Answer 38

inhibits STAT 1, 4, 6

Question 39

Pimozide

Answer 39

neuroleptic drug | inhibits STAT5 phosphorylation & supresses pSTAT5 to cause apoptosis