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CFT I > Exam 1 - Feline Lymphoma > Flashcards

Exam 1 - Feline Lymphoma Flashcards

(97 cards)

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1
Q

what breed is associated with feline lymphoma?

A

siamese cats

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2
Q

what is the most common tumor in renal transplant cats?

A

lymphoma - high grade diffuse large b-cell lymphoma

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3
Q

what organs are involved in cats that get lymphoma after renal transplants?

A

liver, spleen, peripheral/mesenteric lymph nodes, small intestines, bladder, heart, mesenteric fat, & body wall

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4
Q

what is the proposed mechanism for why renal transplant cats get lymphoma?

A

chronic immunosuppresion

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5
Q

what viral factors are apart of the etiology of feline lymphoma?

A

FeLV & FIV

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6
Q

what are the 3 forms of FeLV-associated lymphoma?

A

mediastinal, multicentric, & spinal

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7
Q

what cats are typically affected by FeLV-associated lymphoma?

A

younger cats - under 2 years old

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8
Q

what is the mechanism of FeLV-associated lymphosarcoma?

A

direct mechanism - insertional mutagenesis (virus inserts into the cell)

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9
Q

what is the common immunophenotype of FeLV-associated lymphoma?

A

t-cell

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10
Q

what is the common immunophenotype of FIV-associated lymphoma?

A

b cell lymphoma

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11
Q

what is the mechanism of FIV-associated lymphosarcoma?

A

indirect mechanism - chronic immunosuppression

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12
Q

T/F: there is a five-fold increased risk of lymphosarcoma in FIV positive cats

A

true

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13
Q

there has been an increase in prevalence of lymphoma in cats now past the felv era due to relative frequency of alimentary lymphoma - why?

A

we see it more now but it’s typically in older cats with different forms (alimentary)

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14
Q

how is lymphoma classified in cats?

A

anatomic location & histologic & immunophenotypic criteria

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15
Q

T/F: only 4-10% of cats diagnosed with lymphoma involves the peripheral lymph nodes (multicentric)

A
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16
Q

what is the common name for tarsal lymphoma?

A

terrible tumor of the hock - surrounds the joint fully

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17
Q

what is the most common intestinal tumor in cats?

A

feline alimentary lymphoma - 55%

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18
Q

what cats are typically affected by alimentary lymphoma?

A

older, felv negative cats, & siamese breeds

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19
Q

what other organs can be involved in alimentary lymphoma?

A

intestines, mesenteric lymph nodes, liver, & spleen

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20
Q

what are the clinical signs associated with alimentary lymphoma?

A

weight loss, anorexia, diarrhea, & vomiting

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21
Q

what may be palpated upon physical exam of a cat with alimentary lymphoma?

A

palpable abdominal mass or thickened ‘ropey’ loops of intestine

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22
Q

what is another name for low-grade gi lymphoma?

A

small cell or lymphocytic lymphoma

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23
Q

what pathology is caused by low-grade gi lymphoma?

A

diffuse intestinal wall thickening with intact wall layering

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24
Q

what other organs may be involved in low-grade gi lymphoma?

A

abdominal lymph nodes & liver

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25
what other organs may be involved in high-grade gi lymphoma?
abdominal lymph node involvement, liver, spleen, & kidney
26
what is another name for high-grade lymphoma?
lymphoblastic
27
what pathology is caused by high-grade lymphoma?
transmural intestinal wall thickening, loss of layering, & maybe a solitary mass
28
how is low-grade gi lymphoma diagnosed?
endoscopic or surgical biopsy
29
what other disease is hard to distinguish from small cell gi lymphoma?
IBD
30
how is small cell lymphoma treated?
chlorambucil & prednisolone
31
what percentage of patients with small cell lymphoma respond to therapy?
98%
32
what is the median survival of small cell gi lymphoma?
700 days
33
T/F: the history of a cat with small cell gi lymphoma is typically prolonged and clinical signs aren't as pronounced
true
34
which has the worst prognosis: small cell or large cell lymphoma?
large cell
35
how is large cell gi lymphoma diagnosed?
ultrasound guided FNA & cytology +/- flow cytometry (88% b-cell)
36
what is the treatment for large cell gi lymphoma?
aggressive, multi agent chemo survival benefit found in cats treated with doxorubicin
37
T/F: doxorubicin can cause permanent anorexia in cats
true
38
what is the median survival time of cats with large cell gi lymphoma?
6 months
39
what % of cats with large cell gi lymphoma respond to therapy?
50-60%
40
what is feline large granular lymphocyte lymphoma?
very biologically aggressive subtype of lymphoma arising from CD3+ t cytotoxic t cells
41
what organs are typically involved in feline large granular lymphocyte lymphoma?
small intestines, mesenteric lymph nodes, +/- spleen, liver, & bone marrow
42
what are the clinical signs of feline large granular lymphocyte lymphoma?
acute onset of anorexia, weight loss, lethargy, & vomiting
43
T/F: most cats with feline large granular lymphocyte lymphoma are FeLV/FIV negative
true
44
what is the median survival time of feline large granular lymphocyte lymphoma?
57 days
45
what percentage of animals with feline large granular lymphocyte lymphoma respond to therapy?
<30% - minimally responsive
46
what may you see in cytology when looking at the cytoplasm of cells in cats with feline large granular lymphocyte lymphoma?
granular bodies
47
what are the clinical signs of mediastinal lymphoma?
dyspnea, tachypnea, cough, inappetence, & regurgitation
48
what is the signalment of cats typically affected by mediastinal lymphoma?
younger siamese cats
49
what are 2 common physical exam findings associated with mediastinal lymphoma?
muffled heart & lung sounds, 51% of cats have pleural effusions, & non-compressible thorax
50
how is mediastinal lymphoma diagnosed?
thoracic radiographs, thoracocentesis, +/- ultrasound guided FNA & cytology (diagnose off of pleural fluid)
51
what is the treatment for mediastinal lymphoma?
supportive therapy - thoracocentesis chemotherapy emergency radiation therapy
52
what percentage of animals respond to treatment for mediastinal lymphoma?
94.7% respond to CHOP/COP
53
what is the median survival time of mediastinal lymphoma if the cat is FeLV positive?
2-3 months
54
what is the median survival time of mediastinal lymphoma if the cat is an older FeLV negative patient?
373 days
55
T/F: 60-75% of cats with complete response to therapy had an overall median survival time of 980 days
true
56
what are some commonly reported locations of feline extra-nodal lymphoma?
nasal, upper respiratory, renal, CNS, subcutaneous, & terrible tumor of the hock
57
what are the clinical signs of feline nasal lymphoma?
nasal discharge, stertor, sneezing, epistaxis, & facial deformity/asymmetry
58
what is the typical duration of clinical signs prior to a feline nasal lymphoma patient being referred?
about 3 months
59
what is the common immunophenotype of feline nasal lymphoma?
majority are b-cell lymphoma
60
how is feline nasal lymphoma diagnosed & staged?
thoracic radiographs, AUS, CT with rhinoscopy, & biopsy
61
T/F: approximately 15% of cats with feline nasal lymphoma have disease located beyond the nasal cavity & will require more systemic treatment
true
62
what is the median survival time for feline nasal lymphoma?
536 days
63
what is the median survival time for stage 1 localized feline nasal lymphoma?
955 days
64
how do most cats with nasal lymphoma present?
many cats present with stage 1 disease that is localized to the anatomic site & are still eating well (substage a)
65
what are the average response rates to treatment of feline nasal lymphoma?
66-75%
66
T/F: nasal lymphoma is prognostically the best variant
true - radiation therapy can treat locally!
67
what are the general clinical signs of renal lymphoma?
depression, anorexia, PU/PD, bilateral renomegaly
68
how is renal lymphoma diagnosed?
cytology, thoracic radiographs, ultrasound, & FNA
69
what is the common immunophenotype of renal lymphoma?
b-cell lymphoma
70
what other organ system is commonly affected in renal lymphoma?
relapse in the CNS!!
71
what is the median survival time of renal lymphoma?
4-7 months
72
what are the clinical signs associated with feline CNS lymphoma?
posterior paresis, behavior changes, circling, seizures, & altered consciousness - often diffusely effects cerebrum or brainstem +/- spinal cord
73
T/F: cats with feline CNS lymphoma have concurrent renal and/or bone marrow involvement
true
74
there is a high incidence of what disease in feline CNS lymphoma?
FeLV
75
how is feline CNS lymphoma staged?
thoracic rads & abdominal ultrasound
76
how is feline CNS lymphoma diagnosed?
MRI or CT scan with CSF tap & cytology
77
what is the treatment for feline CNS lymphoma?
local radiation therapy & chemo - cats showing a complete response can enjoy long term disease control
78
what is the median survival time of cats with CNS lymphoma that have a poor response to chemo?
70 days - maybe better survival with lomustine
79
what is the distribution for cutaneous epitheliotropic t-cell lymphoma?
solitary or multiple lesions without predilection for any particular locations
80
what are the dermatological clinical signs of cutaneous epitheliotropic t-cell lymphoma?
erythematous plaques/patches, scaly alopecia patches, & non-healing ulcers or nodules 'eosinophilic plaque like'
81
ulcerative pododermatitis & exfoliative alopecia with focal erythema are commonly seen with what cancer?
cutaneous epitheliotropic t-cell lymphoma
82
how is cutaneous epitheliotropic t-cell lymphoma diagnosed?
skin biopsy & histopathology with immunohistochemistry
83
how is cutaneous epitheliotropic t-cell lymphoma staged?
thoracic rads & ultrasound
84
what is another name for eosinophilic granuloma?
rodent ulcer
85
what is the treatment for cutaneous epitheliotropic t-cell lymphoma?
surgery for ulcerated lesions, electron beam irradiation, & multi-agent chemo
86
what is the median survival time for cutaneous epitheliotropic t-cell lymphoma?
10 months
87
T/F: cutaneous epitheliotropic t-cell lymphoma is rare in cats
true
88
what is the most common form of lymphoma in cats?
gastrointestinal
89
in cats with high grade gi lymphoma, how many animals respond to therapy? what is the average duration of response?
50-70% 4-6 months
90
why is it important to use immunophenotyping & PARR in cats with suspect gi lymphoma?
can help distinguish lymphoma from IBD
91
what are positive prognostic factors for feline lymphoma in regards to response to treatment, histopathology grade, anatomic location, & retroviral status?
complete response low grade FeLV negative nasal lymphoma
92
T/F: in cats, immunophenotype & pre-treatment with glucocorticoids does not play a role in prognosis
true
93
for feline lymphoma, what are the chemo treatment options?
CHOP/COP & lomustine
94
for feline lymphoma, what are the radiation treatment options?
nasal, CNS/spinal lesions, & mediastinal lymphoma
95
for feline lymphoma, what are the surgical treatment options?
rarely indicated because most lymphomas are considered systemic except for getting biopsies for diagnosis or to relieve intestinal obstruction
96
what are the 2 classifications used in feline lymphoma?
anatomic location & histologic criteria
97
what cancer is this?
cutaneous epitheliotropic t-cell lymphoma

CFT I (30 decks)

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