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Dosage Forms II > Exam 1 Flashcards > Flashcards

Exam 1 Flashcards

Liquid Dosage Forms Cards

1
Q

Sucrose

A

Sweetening agent

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2
Q

Sorbitol

A

Sweetening agent

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3
Q

Citric Acid

A

Buffering, antioxidant, chelating agent

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3
Q

Phosphoric Acid

A

Buffering agent

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4
Q

Ethanol

A

Preservative (alcohol), also co-solvent

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5
Q

Benzyl alcohol

A

Preservative (alcohol)

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6
Q

Chlorobutanol

A

Preservative (alcohol)

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7
Q

Benzoic acid

A

Preservative (acid)

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8
Q

Sorbic acid

A

Preservative (acid)

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9
Q

PARABENS

A

Preservative (paraben)

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10
Q

Benzalkonium chloride

A

Preservative (quaternary compound)

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11
Q

Cetyltrimethylammonium chloride

A

Preservative (quaternary compound)

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12
Q

Water

A

Solvent

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13
Q

Vegetable Oils

A

Solvent

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14
Q

Glycerin

A

Co-solvent

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15
Q

Propylene glycol

A

Co-solvent

16
Q

Gallic Acid

A

Antioxidant (free-radical scavenger)

17
Q

Butylated hydroxyanisole (BHA)

A

Antioxidant (free-radical scavenger)

18
Q

Butylated hydroxytoluene (BHT)

A

Antioxidant (free-radical scavenger)

19
Q

Tocopherol; Vitamin E

A

Antioxidant (free-radical scavenger)

20
Q

Sodium Bisulfite

A

Antioxidant (Reducing agent)

21
Q

Ascorbic acid

A

Antioxidant (Reducing agent)

22
Q

EDTA

A

Antioxidant (Chelating agent)

23
Q

Citric acid

A

Antioxidant (Chelating agent)

24
Types of Liquid Dosage Forms
Solution, Emulsion, Suspension
25
Advantages of Solutions
Homogeneous - content uniformity Easy to manufacture Good bioavailability
26
Two things to know in designing a buffer
Desired pH value and buffer capacity??
27
What needs to be done to minimize irritation if solution pH cannot match bodily fluid pH?
Minimize buffering capacity Minimize volume Administer slowly
28
Antimicrobial preservatives mechanism of action
Alcohols, Acids, Esters (parabens)--> Hydrophobic interactions with bacteria Quaternary ammonium compounds--> Electrostatic forces interact with bacteria membrane
29
Polysorbate 80 (tween 80)
Wetting agent (surfactant)
30

Dosage Forms II (1 decks)

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