Exam 1 Material Flashcards

(67 cards)

1
Q

what is the definition of EBM (evidence-based medicine)

A
  1. The integration of best research evidence with clinical expertise and patient values
  2. The conscientious, explicit, and judicious use of the current best evidence in making decisions about the care of individual patients
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Who is the “father of EBM”

A

David Sackett

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Inductive reasoning is ______ to _______

A

specific observation to general conclusion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Deductive reasoning is ______ to ______

A

general observation to specific conclusion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Approximately ___% of patients are seen only 1 time

A

48%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Approximately ___% of patients are seen >2 times

A

25%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the relationship between quality of health care and clinical experience?

A

As clinical expertise increases, quality of care decreases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Statistically better outcomes came from ______ clinicians when working on patients using manual therapy

A

less experienced clinicians (and uncertified) had better clinical outcomes when providing manual therapy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what are the two fundamental principles of EBP

A
  1. There is a hierarchy of evidence
  2. The evidence is never enough (have to include other things)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

When discussing the hierarchy of evidence, which has the most bias control (highly controlled) and therefore leads to the most confidence in results

A

Experimental designs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

When discussing the hierarchy of evidence, which has the least bias control which has the least confidence in results

A

Case report/anecdote

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

In order from highest to lowest bias control, what is the order of the hierarchy of evidence

A

experimental designs
quasi-experimental designs
non-experimental designs
case report/anecdote

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

The great majority of our clinical decisions will be made from the ____ level of evidence

A

Lowest
-Even though there is a hierarchy, people still use clinical experience, expert opinion, and mechanism- based reasoning to make decisions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What does the quote “absence of evidence is not evidence of absence” mean?

A

Just because there are no studies of something does not mean there is evidence that it is wrong or doesn’t work
-using skills that your expertise is telling you works is fine until there is evidence against it

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Generally research evidence is based on ____.

A

Means
-recognize that there are outliers and it doesn’t necessarily represent each individual patient

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the general sequence of the EBP method?

A
  1. Acknowledge there’s something I don’t know
  2. Formulate a foreground question (PICO)
  3. Efficiently search online databases
  4. Select “best available evidence”
  5. Critically appraise evidence
  6. Integrate evidence with clinical practice
  7. Self-evaluation: “How am I doing as an evidence based practitioner ?”
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Background questions

A

-Focused on the medical aspects of the situation
-ex. “what is the most commonly injured ligament in the knee?”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Foreground questions

A

-Help clinicians make decisions about specific PT management
-ex. “In a patient with a ruptured ACL, is proprioceptive training as effective as surgery for returning to sport?”
-PICO format

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What does PICO stand for

A

P= patient/problem
I= Intervention, exposure, or test
C=Comparison (don’t always have to have a comparison)
O=Outcome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What is the function/point of PICO?

A

It is the format to ask foreground questions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

what is the formula for usefulness

A

Usefulness= (validity x relevance)/ work

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Which sources are considered “pre-processed” and what does it mean

A

-Pre-processed means that someone else has already graded the quality (takes less work)
-Systematic reviews (cochrane, DARE)
-Critically Appraised Topics (CATS, Clinical evidence database, FPIN clinical inquiries)
-Specialty specific POEMs
-Critically appraised individual articles (ACP Journal club)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Which sources take the most work

A

Journal articles (MEDLINE, & other databases)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Which sources take the least work

A

Systematic reviews
(Cochrane, DARE)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
The basis of over ___% of each groups choice of treatment interventions reflected what was taught during their ____ training
90% Initial training
26
What is the evidence hierarchy based on?
Confidence interval validity
27
What are the most important sections of a study to read and why? (according to sketchy EBM)
Methods and Results are the most important to read because they are the least biased and most objective parts of the study
28
According to the Ethics in clinical trials video, which is not 1 of the 7 requirements of ethical research? A. Informed consent B. Fair subject selection C. Must benefit subjects D. Scientific validity
C. Must benefit subjects -this is NOT one of the 7 requirements of ethical research
29
What is the primary ethical dilemma in research? A. benefit to current patient vs. future patients B. Equity in subject selection C. Risk vs. benefit to patients D. Internal vs. external validity
A. Benefit to current patient vs. future patients -Benefit to society should outweigh the risks
30
What are the 7 requirements of ethical research?
-Social or scientific value -Fair subject selection -Independent review -Respect for potential and enrolled subjects -Informed consent -Favorable risk-benefit ratio -Scientific validity
31
What are the guiding principles of ethical research?
-beneficence, justice, and autonomy
32
Independent variables (X)
-What you manipulate or specify -aka factors -can have levels
33
Dependent variables (Y)
What you measure
34
____ affects change in the _____
IV affects change in the DV
35
MDC (minimal detectable change)
-Amount of change in a variable that must be achieved to reflect a true change/difference -mathematical multiple of the SEM
36
Inter-rater reliability
-Variation between 2 or more raters who measure the same group of people -best assessed within a single trial (single session)
37
Intra-rater reliability
-The degree that the examiner agrees with themself -scores should match when same examiner tests the same subjects on two or more occasions -Rater bias: when one rater takes 2 measurements and they are influenced by the memory of the first score
38
Test-retest reliability
Used to establish that an instrument/tool is capable of measuring a variable consistently -could be a tool or questionnaire etc
39
What type of patients are not the best for reliability studies?
-any type of condition that noticeably changes over time
40
Alternate/Parallel forms reliability
To see if 2 versions of the same instrument are equivalent ex. goni, questionnaires, etc -they may agree or correlate
41
Internal consistency
-Used in questionnaires to evaluate if the construct is being measured -evaluates scales/questions to estimate how well the items reflect the same construct and if they yield similar results -use cronbachs alpha -Ideal score is between a .7-.9 because if it is perfect we are too redundant with questions
42
split-half reliability
Take all the questions, divide in half and compare the halves
43
What types of reliability only look at questionnaires?
alternate forms and internal consistency (split half's included in IC)
44
What types of reliability do clinicians use?
inter-rater intra-rater test-retest
45
Reliability
reproducibility and consistency
46
Validity
accuracy, correctness
47
Measurement validity**
"Extent to which an instrument measures what it is intended to measure"
48
Can a test be reliable but not valid?
Yes
49
Can a test be valid but not reliable?
NO! It cannot be valid if it is unreliable
50
Validity is a _________
validity is a continuum -not "all or none" -validity must be evaluated within teh context of the test it is trying to perform ("How valid is the instrument for a given purpose" not "how valid is the instrument")
51
What are the three types of validity?
Construct, content, and criterion-related -called the "3 C's" -they overlap
52
Content (face validity)
-Instrument appears to test what it is supposed to test -Least rigorous, subjective and scientifically weak -Not sufficient for outcome measures in research ex. ROM, length, strength, balance, etc
53
What is considered to be the "gold standard" of validity
Criterion validity -Highest and most objective form of validity -
54
Criterion validity
-Concurrent and predictive types of validity -Concurrent validity: measurements between tests taken around the same time (ex. DASH vs quick DASH or doing a lachman's test then sending the patient to get an MRI) Predictive: establishes that the outcome of the target test can be used to predict a future criterion score or outcome ex. Do GRE's predict 1st year success in grad school
55
Construct validity
How well a tool measures an abstract concept/construct ex. health, depression,pain, diability, etc
56
what are the 3 approaches to construct validity
1. Known groups method: -low form of validity - Do test results differ between 2 groups (known to be different) 2. Convergent validity: -Do test results correlate with other similar tests ex. pain and disability (should correlate) 3. Divergent/Descriminant validity: -Low correlation with different tests? -ex. new pain score and height (should not really correlate)
57
What are some issues affecting validity of change
-levels of measurement -Reliability -Stability -Baseline score
58
Responsiveness
"the ability of an instrument to detect minimal change over time" -measured by MDC and MCID
59
MDC (minimal detectable change)
"the ability of an instrument to detect change beyond measurement error" -ex. how much would a patient have to improve their ROM before we are confident that it isn't due to measurement error but that it is a real change
60
MCID (minimal clinically important difference)
-The ability of an instrument to detect minimally important change -smallest difference that signifies an important rather than trivial difference -larger than the MDC -should be clinically important to patient
61
MDC concerns ____ while MCID concerns _____ (reliability or validity)
MDC concerns reliability: because its measurement error MCID: concerns validity: because it gets at what we are intending to measure/important to the patient etc
62
Sample parameter
-statistics or values that summarize a population -Created by taking a random sample of a population -If they summarize the sample we call them statistics
63
Population
Persons, objects or events that meet a specific set of criteria
64
Target population
The larger population to which the results of a study will be generalized to
65
Accessible population
The actual population of subjects available to be chosen for a study (a subset of the target population)
66
Sample
A subgroup of the population of interest (accessible population) which allows the results of research to be generalized to the population
67