Exam 1: Porphyrias Flashcards Preview

Anesthesia Pharmacology (Summer) > Exam 1: Porphyrias > Flashcards

Flashcards in Exam 1: Porphyrias Deck (6)
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1
Q

Porphyrins are:

A

Primary precursors of heme

2
Q

Porphyria is:

A

Inborn deficiency of any enzyme in the heme pathway, leading to accumulation of precursors during times of increased heme production, which are toxic to tissues at high concentrations

3
Q

Inheritance pattern:

A

Autosomal dominant
Chromosome II
Non-sex linked
Variable expression

4
Q

Attacks most frequent in:

A

20 and 30-something females

5
Q

Triggers:

A
Hormonal fluctuations
Menstruation
Fasting/NPO/hypovolemia
Dehydration
Stress
Infection
6
Q

S/S of attacks:

A
Abdominal pain w/ N/V
ANS instability: tachycardia, HTN
Electrolyte disturbances
Skeletal muscle weakness
Resp. failure
Seizures
Neuropsychiatric disturbances