Exam 1 Review Flashcards
(139 cards)
1
Q
Acetic acids NSAIDs - 2
A
Etodolac
Diclofenac
2
Q
Celecoxib MAX
A
400mg
3
Q
Qd
A
Every day
4
Q
1 oz = __g
A
30g
5
Q
1 fl oz = __mL
A
30mL
6
Q
1 lb = ___kg
A
.45kg
7
Q
Diclofenac MAX
A
1200mg
8
Q
Albumin has a strong affinity for weak acids. Which drug did we use as an example for high affinity protein binding?
A
Penicillin
9
Q
Ibuprofen MAX
A
2400-3200mg
10
Q
Sq (sc)
A
Subcutaneous
11
Q
1 kg = ___ lb
A
2.2lb
12
Q
APAP dosing
A
325-650mg q 4-6hr
1000mg q 6-8 hr
13
Q
1 lb = ___g
A
454g
14
Q
4 drugs with established therapeutic ranges
A
Digoxin
Lithium
Phenytoin
Cyclosporin
15
Q
C fibers features
A
Unmyelinated
Slow
Dull, aching pain
16
Q
All opioids we talked about are schedule II - which two arent and what schedule are they?
A
(III) codiene + APAP (tylenol #)
(IV) tramadol
17
Q
Naproxen dosing
A
500mg stat
250-500mg q 6-8hr
18
Q
Naproxen Na MAX
A
1375mg
19
Q
Propionic acid NSAIDs - 4
A
Ibuprofen
Flurbiprofen
Naproxen
Naproxen Na
20
Q
Which are the phenanthrene opioids?
A
Codiene Hydrocodone Oxycodone Morphine Hydromorphone
21
Q
APAP CD
A
1000mg
22
Q
Which LA is best used for dental infections (bc it’s pKa is the most acidic)?
A
Mepivicaine
23
Q
ASA analgesic/pyretic dosing
A
325-600mg q 4-6hr
24
Q
1 gram = ___ grain (gr)
A
15.4 grain
25
ASA classification
Acetylated salicylic acid derivative
26
ASA MAX
4000MG
27
ASA adult LD
10-30gm
28
APAP MAX with liver disease
2000mg
29
Etodolac MAX
1500mg
30
6 schedule II drugs
```
Morphine
Oxycodone
Hydrocodone
Hydromorphone
Codeiene (alone)
Cocaine HCl
```
31
Selective COX2 inhibitor NSAID - 1
Celecoxib
32
Diflunisal MAX
1500mg
33
1 L = __ qt
1.06qt
34
Flurbiprofen dosing
50-100mg BID/QID
35
Naproxen MAX
1250-1500mg
36
1 schedule III drug
Tylenol #3
37
ASA kid LD
4gm
38
Ac
Before meals
39
Po
By mouth
40
Etodolac dosing
200-400mg q 6-8 hr
41
Qod
Every other day
42
Name 2 drugs that undergo the 1st pass effect (if taken orally)
Morphine
| Nitroglycerine
43
A delta fibers features
Myelinated
Fast
Sharp pain
44
APAP MAX
3000-4000mg
45
2 drugs with active metabolites
Codeine (morphine)
| Benzos
46
Difunisal classification
Non acetylated salicylic acid derivative
47
Diflunisal dosing
500-1000mg stat
| 250-500mg q 8-12 hr
48
Celecoxib dosing
400mg stat
| 100-200mg BID
49
1 tbsp = __cc
15cc
50
Ibuprofen CD
400-800mg
51
ASA antiplatelet dosing
81-325mg
52
How many half lives does it take to reach steady state concentration?
4-5 t1/2's
53
ASA CD
1000MG
54
Diclofenac dosing
50mg TID
55
Schedule IV class of drugs
Benzos
56
Qs
Sufficient quantity
57
Hs (qhs)
@ bedtime
58
Pc
After meals
59
1 tbsp = __tsp
3 tsp
60
Drug with a toxic metabolite
APAP
61
1 tsp = __cc
5cc
62
1cc = ___mL
1mL
63
Flurbiprofen MAX
300mg
64
Sig
Directions for use
65
Naproxen Na dosing
275-550mg stat, then q 6-8 hr
66
Primary prostaglandin involved in pain
PGE2
67
1 gr = __mg
60mg
68
Which are the phenylpiperidine opioids?
Meperidine (Demerol)
69
Ibuprofen dosing
400-800mg q 4-6 hr
70
Which opiods have active metabolites? (4)
Codiene
Hydrocodone
Oxycodone
Morphine
71
Which opiods are subject to CYP polymorphism (2D6)? - 3
Codiene
Oxycodone
Tramadol
72
Codiene dose forms
15-60mg
73
Codiene dosing
30-60mg q4-6hr
74
Codiene + APAP dosage forms
7.5-60mg codiene
| 300mg APAP
75
Codiene + APAP dosing
30-60mg codiene q4-6hr
| <4gm qd
76
Hydrocodone + APAP dosage forms
2.5-10mg hydrocodone
| 325mg APAP
77
Hydrocodone + APAP dosing regimen
5-10mg hydrocodone q4-6hr
| <4gm qd
78
Hydrocodone + ibuprofen dosage forms
5-7.5mg hydrocodone
| 200mg ibuprofen
79
Hydrocodone + ibuprofen dosing regimen
1-2 tabs q4-6hr
80
Oxycodone + APAP dosage forms
2.5-10mg oxy
| 325mg APAP
81
Oxycodone + APAP dosing regimen
2.5-10mg oxy q6hr
| <4gm qd
82
Oxycodone + ibuprofen dosage forms
5mg oxy
| 400mg ibuprofen
83
Oxycodone + ibuprofen dosing regimen
1 tab q6hr
84
Oxycodone + ASA dosage forms
5mg oxy
| 325mg ASA
85
Oxycodone + ASA dosing regimen
1 tab q6hr
86
Morphine dosage forms
15-60mg
87
Morphine dosing regimen
10-30mg q4hr
88
Hydromorphone dosage forms
2mg
| 4mg
89
Hydromorphone dosing regimen
2-8mg q3-4hr
90
Meperidine dosage forms
50mg
| 100mg
91
Meperidine dosing regimen
50-150mg q2-4hr
92
Most potent opioid
Hydromorphone
93
Least potent opioid
Codiene
94
Evizo dosage forms
2mg (.4mL) prefilled auto injectors IM/SQ into thigh
95
Narcan Nasal spray dosage forms
2mg
| 4mg
96
Evizo dosing regimen
2mg q2-3min
97
Narcan nasal spray dosing regimen
1 spray q2-3min
98
Narcan injectable dosage forms
IV, SQ, IM
.02mg/mL
.4mg/mL
1mg/mL
99
Narcan injectable dosing regimen
.4-2mg repeated 12-3min (up to 10mg)
100
Typical duration of max pain intensity
2-3 days
101
DOC for mild/moderate pain
400-600mg ibuprofen
102
Fetal [drug] = __% of maternal [drug]
50-100%
103
Pregnancy antibiotic DOC
(B lactam ring)
Penicillins
Cephalosporins
104
Pregnancy antibiotic DOC w PCN allergy
Azithromycin (macrolide)
| Clindamcin (lincosamide)
105
Pregnancy antifungal DOC
Nystatin
| Clotrimazole
106
Pregnancy antiviral DOC
Penciclovir
107
Pregnancy nonopioid analgesic DOC
APAP
108
Pregnancy opioid DOC
Oxycodone + APAP
109
Nitrous oxide - fetal [plasma] = ___% of maternal
80%
110
Pregnancy LA DOC
Lidocaine
| Prilocaine
111
Which drug has a black box warning for peds pts?
Codeine - metabolize too quickly
112
You can give a kid an adult dose @ ___kg body weight
40kg
113
What are the 3 categories of drugs that are the biggest culprits of xerostomia?
Strong diuretics
Incontinence meds
Strong anticholinergics
114
Strong anticholinergics are known to cause xerostomia. Which 3 drug classes are included in this?
TCAs
Psychotropics
Opioids
115
Strong diuretic - culprit in xerostomia
Furosemide (Lasix)
116
Incontinence meds that cause xerostomia (2)
Oxybutynin (Ditropan)
| Tolterosdine (Detrol)
117
4 psychotropics (strong anticholinergics) that cause xerostomia
Quetiapine
Mirtazapine
Risperidone
Olanzapine
118
TCA (strong anticholinergic) causing xerostomia
Amitriptyline
119
Max # of LA carps/visit for old ASA II + III pts
2-3 carps
120
Biggest risk of NSAID use in elderly pts
Ulcers
| 60% of elderly people can have asymptomatic ulcers
121
Most ADEs caused by LAs in elderly is caused by what?
Vessel injection
| Use gow gates
122
DOC for elderly anxiolytics?
2nd generation benzos - Lorazepam (starting w ½ dose)
| NOT VALIUM
123
What is ALWAYS the DOC analgesic for elderly
APAP
124
The max daily dose of APAP is 3-4gm/day. What are the 2 conditions in the elderly that you need to adjust the MAX for? How do you adjust it?
Hepatic insufficiency
Alcohol abuse
Decrease by 50-75%
125
If an elderly pt can't take APAP, what are the NSAID options?
Ibuprofen
| Salsalate
126
What are the 2 opioid options for elderly pts?
APAP + codeien #2 or #3
| Oxycodone/APAP
127
What are the 6 meds on the Beers list of potentially inappropriate meds for older adults that are often used in dentistry?
```
Diphenhydramine
Long acting NSAIDs
Meperidine
Pentazocine
Long acting benzos
Muscle relaxants
```
128
List 4 characteristics of drugs commonly involved in ADIs?
CYP450 involved
Highly protein bound
Chronic use
Narrow TI
129
6 drugs that have a narrow TI that are commonly involved in ADIs
```
Digoxin
Warfarin
Cyclosporine
Lithium carbonate
Methotrexate
Phenytoin
```
130
3 highly protein bound drugs that are commonly invovled in ADIs
Warfarin
Phenytoin
Sulfonylureas (glybride)
131
What class of drugs is commonly invovled in ADIs due to their tendency to displace other protein bound drugs?
NSAIDs
132
Epinephrine has DIs with? 2
TCAs
| Coke, meth
133
NSAIDs DIs - 4
Alcohol
HTN drugs (ACEIs, diuretics, beta blockers)
SSRIs
Low dose ASA
134
NSAIDs or ASA has DI which which drug?
Warfarin
135
Tetracyclines have interactions with which 3 drugs?
Dairy products
Antacids
Ca + Fe supplements
136
Metronidazole has interactions with which 2 drugs
Lithium
| Alcohol
137
Amoxicillin has interactions with which drug
Warfarin
138
Azithromycin and clarithromycin has interactions with which drug
Digoxin
139
Benzos have interactions with which 5 drugs
```
Alcohol
Opioids
Antihistamines
Macrolide antibiotics
Protease inhibitors
```
