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Dosage Forms 2 > Exam 1 Spring 2022 Questions > Flashcards

Exam 1 Spring 2022 Questions Flashcards

1
Q

The following describes solution dosage forms. Choose two descriptions that are relevant

A

Good bioavailability, easy to manufacture..

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2
Q

Which one of the following will produce a buffer solution of 7.4 with a buffering capacity of 0.1?

A

Monosodium phosphate 0.072 mol and dipotassium 0.11mol in 1L of water

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3
Q

Which one of the following helps minimize tissue irritation due to parenteral, opthalmic, or nasal solutions?

A

Reduce the volume of administered solution

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4
Q

The following substances play a similar role in liquid dosage forms, but _________ works in a different mechanism than the others.

A

Benzalkonium chloride

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5
Q

A solution contains the following ingredients: Sorbitol, sodium bisulfite, EDTA, Propyl paraben, glycerin. Which of the following is used as a reducing agent (consuming oxygen)?

A

Sodium bisulfite

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6
Q

A buffer contains 0.1M sodium formate and 0.1M formic acid. 0.02 of sodium hydroxide was added. The pKa value of the formic acid is 3.75. What is the pH after the addition of sodium hydroxide.

A

3.27

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7
Q

Which of the following does not require a preservative?

A

Single use ampules for injection

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8
Q

Creaming is a type of emulsion instability, which is irreversible and will form separate layers of oil and water. Creaming cannot be fixed by shaking thus the product needs to be reformulated. T/F

A

False

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9
Q

Which is a different type of emulsion than the others? (W/O, O/W)
Emulsion stabilized with Tween 80
Emulsion stabilized with charcoal
Emulsion containing 20% petroleum and 80% water
Emulsion stabilized with bentonite
Emulsion used for water washable lotion

A

An emulsion stabilized with charcoal

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10
Q

Which of the following describes interfacial phenomena in emulsion INCORRECTLY?

A

Surfactants with HLB value > 10 are typically used to stabilize a W/O emulsion

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11
Q

Parenteral nutrition can be administered as an O/W emulsion T/F

A

True

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12
Q

An O/W emulsion including sodium stearate should not be prepared with hard water. Why?

A

Hard water can induce phase inversion of the emulsion

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13
Q

The following describes ingredients of ArthriCare medicated rub which is incorrect?
Cetyl alcohol - emulsifier and thickening agent
Stearyl alcohol - Emulsifier and thickening agent
Polysorbate 60 - preservative
Sodium lauryl sulfate - emulsifier
Propylene glycol - humectant

A

Polysorbate 60 - preservative

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14
Q

The following ingredients serve similar purposes in an emulsion product, but one of them fulfills this role with a different mechanism than the others
Bentonite
Sodium lauryl sulfate
Magnesium aluminum silicate
Aluminum hydroxide
Charcoal

A

Sodium lauryl sulfate

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15
Q

You are asked to prepare 1 L of O/W emulsion of an oil having a HLB value of 9 with Span 65 (HLB 2) and Brij 56 (HLB 13). The total surfactant concentration should be 0.5% (0.5 g per 100 mL). Calculate how much Span 65 and Brij 56 are required.

A

1.82g Span 65 and 3.18g Brij 56

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16
Q

Which of the following describes a dispersed suspension best?
Cloudy suspension
Large sediment volume
May appear as a semi-solid when undisturbed but is fluid when shaked
Easily redispersed by shaking
high rate of sedimentation

A

Cloudy suspension

17
Q

Which is relevant to suspensions?

A

For bitter drug, suspension is more palatable than solution
Suspension is used to enhance dissolution of poorly soluble drug

18
Q

The following is the formulation of Pepto-Bismol. Choose components that play similar roles in this formulation. Bismuth subsalicylate, Benzoic acid, D&C Red No. 28, Magnesium aluminum silicate, Methylcellulose, Sodium saccharin, Salicylic acid, Sodium salicylate, Sorbic acid, Water

A

Magnesium aluminum silicate and methylcellulose

19
Q

Which one is the least relevant to the structured vehicle system?
Thixotropy
Non-newtonian flow
Shear thinning
Plastic flow
Dilatant flow

A

Dilatant flow

20
Q
  1. You intend to make a sulfadiazine suspension. The particle size of sulfadiazine as received is 26ȝm, and water
    with a density of 1 g/mL is currently used as a vehicle. In order to reduce the settling velocity of drug particles in
    suspension, the following can be done. What is LEAST relevant?
    A: Particle size is reduced to 5 ˩m by micronization.
    B: A sorbitol solution with a viscosity of 110 cps is used instead of water.
    C: Diluted bentonite magma (clay) is added to reduce repulsive forces between the drug particles.
    D: A sorbitol solution with a density of 1.3 g/mL is used as a suspension vehicle.
A

C: Diluted bentonite magma (clay) is added to reduce repulsive forces between the drug particles.

21
Q
  1. The following describes different approaches to formulate a suspension product with a long shelf-life. One of them employs a different principle than the others. Which one is it?
    A. A: Reduce the repulsive forces between drug particles to form floccules.
    B: Electrolytes, clay, or surface-active agents are used to create a secondary minimum in the potential energy vs. particle distance plot.
    C: The suspension may settle fast, but the sediment is loose and easy to redisperse.
    D: The suspension is very thick and does not allow settling of drug particles when undisturbed but becomes fluid when shaken
A

D: The suspension is very thick and does not allow settling of drug particles when undisturbed but becomes fluid when shaken

22
Q
  1. The following lists components and the functions of Rhinocort Aqua Nasal Spray suspension. Which one of the following is INCORRECT?
    a. A: Budesonide - Active ingredient
    B: Carboxymethylcellulose - Structured vehicle system
    C: Ethylenediaminetraacetic acid (EDTA) - Chelating agent to help prevent oxidation
    D: Sorbic acid - Flocculating agent
    E: Magnesium aluminum silicate - Structured vehicle system
A

D

23
Q
  1. Which processes occur during aging of a suspension to bring deltaG (free energy) toward zero?
A

Particles aggregate

24
Q
  1. Which of the following lists components and the functions of Rhinocort Aqua Nasal Spray suspension. Which two of the following is INCORRECT?
    A. Gelatin
    B. Kevlar
    C. Rayon
    D. Cellulose
    E. Teflon
A

A and D

Dosage Forms 2 (3 decks)

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