Exam 2

Question 1

Functions of B-cell membrane proteins CD21, CD19, CD81 and CD225

Answer 1

They are B-cell coreceptors AKA TAPA-1 that enhance signal transduction through the BCR.
Lowers the threshold for the level of Ag required to activate B cells after binding to Ig.

Question 2

Which would not be found on a memory B cell?

Answer 2

Surrogate L chains

Question 3

Which pairs of cell surface proteins do NOT interact with each other?

Answer 3

Membrane Ig on the B cell and CD4 on the T cell

Question 4

Which is found on the surface of every B, T, and pancreatic cell?

Answer 4

MHC Class I

Question 5

TCR is found where?

Answer 5

As a transmembrane protein on the surface of all T cells

Question 6

The signal transduction molecule assoc with TCR is what?

Answer 6

CD3

Question 7

Incorrect statement concerning TCR and Ig genes

Answer 7

Both Ig and TCR are able to switch C-region usage

Question 8

High affinity B-cell clones in mammals are usually generated by

Answer 8

Somatic hypermutation

Question 9

Which is expressed on the surface of the mature B lymphocyte?

Answer 9

CD40
MHC Class II molecules
CD32
IgM and IgD
(All of the above)

Question 10

Hemolytic disease of the newborn AKA Rh incompatibility is the result of what?

Answer 10

Rh- mom conceiving an Rh+ child

Question 11

Serum from Rh+ patient agglutinates RBCs from patient who is blood type AB Rh- positive. What is the blood type of the first patient?

Answer 11

Type O+

Question 12

The development of self-tolerance in the T-cell compartment is important for the prevention of autoimmunity. Which results in T-cell self-tolerance?

Answer 12

Negative selection–removes developing T cells with potential reactivity to self-molecules.

Question 13

What statement about CD8+ CTL is incorrect?

Answer 13

They cannot kill CD4+ T cells.

Question 14

Germinal centers found in the lymph nodes and spleen:

Answer 14

Are sites where antigen-activated mature B cells proliferate and differentiate

Question 15

If infected with virus, which cell will present via antigen to T cells?

Answer 15

B cells
Liver cells
Macrophages
Dendritic cells
(All of the above)

Question 16

MHC Class I molecules are important for which of the following?

Answer 16

Binding to CD8 moleules on T cells.

Question 17

T/F: CD4+, CD8+ T cells form majority of T cells in the thymus.

Answer 17

True

Question 18

TCR on mature T cells is composed of what?

Answer 18

Gamma and delta peptide chains
Alpha and beta peptide chains

Question 19

Role of APCs in immune complex is all except

Answer 19

CD8+ T cells

To present non-self peptides assoc with MHC Class I molecules to CD4+ T cells

Question 20

What is true about staphylococcal toxic shock syndrome?

Answer 20

TSST binds to MHC and T cell receptors without being processed, superantigen activates abnormally high #s of T cell causing them to divide and release cytokines, and shock symptoms are caused by high concentrations of inflammatory cytokines released by activated T cells.

Question 21

Match: CD3 ->

Answer 21

TCR signal transduction molecules

Question 22

Match: MHC Class I ->

Answer 22

HLA A, HLA B, HLA C

Question 23

Match: TH17 ->

Answer 23

Proinflammatory cytokine responses to fungi and extracellular bacteria

Question 24

Match: Ig alpha and Ig beta ->

Answer 24

Contains ITAMS necessary for signal transduction after BCR is engaged

Question 25

Match: TH1 ->

Answer 25

Cell mediated immunity, killing of virus or bacterially infected host cell

Question 26

Match: TH2 ->

Answer 26

Activated eosinophils in response to worms and allergens and B cell to produce Abs

Question 27

Match: MHC Class II ->

Answer 27

HLA DP, HLA DQ, HLA DR

Question 28

Match: Treg cells ->

Answer 28

Inhibits function of other sets of T cells and non-T cells

Question 29

Match: superantigens ->

Answer 29

Nonspecific activation of T cells

Question 30

Match: gamm-delta T cells ->

Answer 30

Small subset of T cells found in the gut and mucosa of the skin

Question 31

How does a pregnancy test work?

Answer 31

A urine specimen reacts with a small amount of hCG antibody, then the latex beads in the soln coated with rabbit anti-hCG antibody are added. If the patient doesn't have hCG, the hCG body would combine with the latex beads and produce a visible agglutination. Agglutination is a negative reaction indication that the patient isn't pregnant.

Question 32

Ouchterlony lab: what type of reaction was measured in this lab exercise?

Answer 32

Precipitation rxn

Question 33

CD40 interacts with

Answer 33

CD40L/CD154 to induce class switch recombination

Question 34

B7 interacts with

Answer 34

CD28 and CTLA-4

Question 35

ICOS Ligand interacts with

Answer 35

ICOS on activated T cells

Question 36

Cytokine receptors

Answer 36

Receptors fo T-cell derived cytokines like IL-4 and IFN-gamma

Question 37

CD3 (under TCR)

Answer 37

Signal transduction molecules assoc with the TCR

Question 38

CD4 or CD8

Answer 38

Co-receptors or co-stimulator molecules

Question 39

CD28 and CTLA-4

Answer 39

Interacts with B7 expressed on APC and B cells

Question 40

CD40L interacts with

Answer 40

CD40 expressed on APC and B cells

Question 41

ICOS (T cell) interacts with

Answer 41

ICOS ligand on B cells

Question 42

T cell adhesion molecules

Answer 42

LFA-1 ICAM-3 CD2 Integrins

Question 43

T cell selectins

Answer 43

Homing to lymph nodes and specific tissues Ex. CD62L