Exam 2 Flashcards

1
Q

What is the function of ACh and how is it removed from the synaptic cleft?

A
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2
Q

What are the two major typed of AChRs?

A
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3
Q

What are the structural and functional differences between AChRs?

A
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4
Q

Facilitation

A
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5
Q

Depression

A

rapid decrease in synaptic strength during sustained synaptic activity

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6
Q

How long does synaptic depression last?

A

hundreds of milliseconds

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7
Q

mechanisms of synaptic depression

A

depletion of readily releasable pool (RRP) of synaptic vesicles
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V
declined NT release

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8
Q

How is synaptic depression correlated to the amount of transmitter release?

A

more transmitter release = more depletion of readily releasable vesicles

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9
Q

Augmentation and Potentiation

A

after repeat synaptic activity, increase in synaptic strength over a longer time scale than synaptic facilitation

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10
Q

How long does augmentation last

A

over a few seconds

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11
Q

How long does potentiation last?

A

tens of seconds to minutes

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12
Q

Mechanisms of augmentation

A

elecation of presynaptic calcium levels

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13
Q

Synaptic Plasticity

A

the ability of synapses to strengthen or weaken synaptic transmission in response to neural activity over time

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14
Q

Short term plasticity

A

changes last for a few minutes or less

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15
Q

Increased synaptic strength due to enhanced NT release leads to:

A

synaptic facilitation, augmentation, and potentiation

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16
Q

Reduced synaptic strength due to decreased NT release leads to:

A

synaptic depression

17
Q

Long term plasticity

A

changes last for 30 minutes or more

18
Q

Long term potentiation

A

Increased synaptic strength due to increased AMAP receptors in postsynaptic cell surface

19
Q

Long term depression

A

decreases synaptic strength due to AMAP receptors in postsynaptic cell surface

20
Q

Synaptic facilitation

A

rapid increase in synaptic strength that occurs when two or more AP invade the presynaptic terminal within a few milliseconds of each other

21
Q

How long does synaptic facilitation last

A

tens of milliseconds

22
Q

What is the mechanism behind synaptic facilitation

A

calcium builds up by several AP arrive close together in time.
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V
prolonged elevation of presynaptic calcium levels
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V
more NT to be released by a subsequent presynaptic action potential