Exam 2 Flashcards

(198 cards)

1
Q

Salivary amylase

A

Breaks down carbohydrates break down into glucose
Is used in mouth, pancreas, and small intestine

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2
Q

Lipase

A

Breakdown fats into fatty acids
Produced by the mouth, pancreas, and stomach

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3
Q

Mechanical digestion in the stomach

A

Food churns with digestive enzymes to make chyme (acidic soup)

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4
Q

Mechanical digestion in the small intestine

A

Localized contractions that mix contents together (help facilitate absorption)

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5
Q

Energy currency for the body

A

Glucose (the breakdown of carbohydrate)

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6
Q

Storage form of quick energy

A

Glycogen (storage form of carbohydrate)

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7
Q

Fats contain and provide

A

Contain: Essential fatty acids
Provide: alternate storage form of energy

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8
Q

Which fats are healthy and which fats are unhealthy

A

Healthy: polyunsaturated fats (found in fish) (protect against CVD)
Unhealthy:saturated fats

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9
Q

Proteins function

A

Primary function: tissue rebuilding and maintaing body tissue
Can also: be converted to supply energy (if needed bc carb and fat is not sufficent)

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10
Q

What minerals help give strength to bones and teeth

A

Phosphorus and calcium

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11
Q

Vitamin C produces

A

The intracellular ground substance that cements tissues together and prevents tissue bleeding

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12
Q

Amino acids serve as the building blocks for

A

Body tissues
Enzymes
Hormones

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13
Q

Thiamin controls

A

The release of energy for cell work

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14
Q

Vitamin B12

A

Needed for synthesis and maturation of RBCs
(Heme formation)

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15
Q

What does water form/function as

A

Form: blood, lymph, intracelluar fluids(important for transporting nutrients and removing waste)
Functions as: regulatory agent (providing fluid environment for metabolic reactions)

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16
Q

Xerostomia is?
Can lead to ?

A

(Dry mouth)
Prolonged drastic reduction of salivary secretions

Infection and ulcers and tooth decay

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17
Q

Xerostomia can be caused by

A

Radiation therapy (damages salvilary glands)
Diabetes
Parkinson’s disease
Autoimmune defficncy disease
Medications (for managment of cardiac failure, hypertension, depression, chronic pain)

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18
Q

What are the three pairs of salivary glands

A

Parotid
Submaxillary
Sublingual

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19
Q

Salivary glands produce

A

Watery fluid containing salivary amylase (binds to starch molecules)
Mucous (to lubricate and bind food)

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20
Q

Lingual lipase

A

Second enzyme released in the saliva
Begins digestion of fats

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21
Q

Salivary secretions important functions (other than chemical digestion)

A

Moisten food so bolus can form and move down esophagus easily
Lubricate and cleanse teeth
Destroy harmful bacteria
Neutralize toxic substances entering the mouth

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22
Q

GERD

A

Gastroesophageal reflux disease (heartburn)
Regurgitation occurs when acidic stomach contents are able to move back into the esophagus
This can damage tissues in esophagus
(GERD is increased with obesity, overeating, smoking, medications)

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23
Q

Hydrochloric acid is important for

A

Breaks down proteins into amino acids
Creating acidic environment needed for pepsin activation and other enzymes
Is the reason we need mucous to protect the stomach lining

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24
Q

Mucous in the stomach is important for

A

Protecting the stomach lining from eroding effect of the acid
Also binds and mixes the food mass and helps move it along

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25
Enzymes in the stomach
Pepsin- begins breakdown of protein (secreted from pepsinogen and activated by HCL) Gastric lipase- acts only on butter fat (has minor role, produced in small amounts) Rennin- aids in coagulation of milk (only found in children)
26
Decrease in HCL would (could occur in aging adults bc decreased secretions)
Hinders production of vitamin B12 Reduces uptake of thiamin, folate, calcium, iron
27
Older adults changes to GI system
Chewing and swallowing issues (dysphasia) Constipation (decrease peristalsis bc of neural and muscular function changes ) Early satiety (limits food ingested which can lead to malnutrition)(changes in hypothalamus) Changes in intestinal microbiota (alter immune function) Decreased secretions (Xerostomia) (HCL) Decreased thirst (dehydration)(caused by changes in hypothalamus)
28
Haw many calories does a male /female need a day if they are older then 70yrs old
Energy needs: Male - 2100 kcal/day Female - 1600 kcal/day (more if active)
29
How many calories a day does a female/male need if they are under 70 yrs old
energy needs: Male - > 2200 kcal/day Female – > 1900kcal/day (more if active)
30
How many calories a day does a female/male need if they are under 70 yrs old
energy needs: Male - > 2200 kcal/day Female – > 1900kcal/day (more if active)
31
How much protein do you need per day (under 70 & over 70)
Under 70: 0.8 gram/kg/day body weight Over 70: 1 gram/kg/day of body weight -prevent age-related muscle loss
32
In a well balanced diet for a healthy person how many total kilocalories come from carbohydrate and what type should you have
45-65% of total kcalories come from carbohydrate, the majority should be obtained from complex carbohydrates (starch), and only a smaller amount obtained from simple carbohydrates (sugars)
33
In a well balanced diet for a healthy person how many total kilocalories come from carbohydrate and what type should you have
45-65% of total kcalories come from carbohydrate, the majority should be obtained from complex carbohydrates (starch), and only a smaller amount obtained from simple carbohydrates (sugars)
34
It is recommended that fat supply your diet at no more then
20-35% of total kcalories
35
Vitamin D recommendations for under and over 70
Under 70: Vitamin D- 15 mcg/day Over 70: Vitamin D- 20 mcg/day (↓ sun exposure & skin synthesis)
36
Calcium recommendations for under/over 70 yrs old
Under 70: Calcium-1000 mg/day 1200 mg/day (women > 50 d/t menopause) Over 70: Calcium- 1200mg/day ↑ d/t bone resorption and ↓ vitamin D levels
37
Iron recommendations for under/over 70
Under 70: Iron- 18 mg/day ↓ 8mg/day after menopause Over 70: Iron- 8mg/day
38
Vitamin B12 recommendations under/over 70 yrs old
Under 70: Vitamin B12: 2.4 mcg/day Over 70: Vitamin B12: 2.4 mcg/day (fortified foods and supplements)
39
Vitamin A role in wound healing
Maintenance of skin and mucous membranes Promotes immunity (migration of macrophages)
40
Vitamin E role in wound healing
Anti-inflamatory properties
41
Vitamin K and Ca role in wound healing
Blood clotting
42
Protein role in wound healing
build and repair of skin and tissues, fight infection, balance fluids
43
Vitamin C role in wound healing
Enhances tensile wound strength Blood vessel formation
44
Vitamin B12 role in wound healing
tissue repair, granulation tissue, energy boost
45
Nursing Interventions to Promote Nutrition
Maintain good oral hygiene Small, frequent meals Environment Position Favorite foods Pain control Collaborate with dietician and/or speech therapy Promote a balanced diet
46
My plate recommends
5 food groups: 1⁄2 plate fruits and veggies 1⁄2 plate grains and proteins one dairy helping
47
My plate recommends (cups and oz for each food group) based on 2,000 calorie plan
2 cup fruit 2 1/2 vegetables 6 oz grains 5 1/2 oz proteins 3 cups dairy
48
Why do older adults tend to need fewer kcal for energy
Bc of a decrease in: Lean body mass Physical activity BMR
49
Changes that make it difficult for an older adult to achieve good nutrition
Loss of interest in eating Decreased sensation of thirst Decrease in taste and smell (make therapuetic diets unappealing) Tooth loss and gum disease Arthritic hands making preparing and eating food difficult gatroespohageal reflux decreased secretions of HCL Decreased intestinal peristalsis Glucose intolerance No longer able to drive, harder and more expensive to get food
50
Frail elderly syndrome
Disorder characterized by weight loss, decreased activity and interaction, increasing frailty
51
Why was potassium added to the nutrition label
Bc it is a good electrolyte to maintain cardiovascular function/health and maintain blood pressure
52
What type of things does a Nutritional History & Screening look at
Eating habits and appetite Food allergies Medical conditions Dentition, chewing, or swallowing difficulties Weight loss Body Mass Index
53
What is a nutrition screening defined as
The process of identifying characteristics known to be associated with nutrition problems, with the purpose of identifying individuals who are malnourished or at a nutritional risk (collect data about eating behaviors and identify possible nutritional risks or deficiencies)
54
When should you be concerned about weight loss
Unintentional weight loss of 10% or more of the usual body weight within 6 months, or 5% of the usual body weight within 1 month
55
If a patient is in need of dentures who should you refer to
Social services
56
Should edema account for weight
No, this contributes to volume and not weight and should not be related to food intake (could occur in kidney or liver disease)
57
Measurements of body size, weight, and proportions
Anthropometric measurements, are used to assess nutritional status and growth
58
BMI
Body mass index is a ratio of weight to height and can be correlated with overall mortality and nutritional risk (Does not estimate body composition such as lean body mass or adiposity)
59
Underweight BMI
≤ 18.5
60
Normal BMI
18.5 ‐ 24.9
61
Overweight BMI
25.0‐<30
62
Obese BMI
≥ 30.0
63
Extreme obesity BMI
≥ 40.0
64
How can laboratory data be used in a nutritional screening and assesment
electrolytes, glucose, lipid panel (shows cholesterol), liver and renal function, complete blood count, vitamins, minerals
65
When completing the nutritional assessment what are some observation/ signs and symptoms you should be looking for
Observations: alertness able to sit upright managing secretions coughing strength Hx of aspiration pneumonia Signs and symptoms: Poor skin turgor or edema Pallor, spoon‐shaped nails (Iron) Bleeding abnormalities (vitaminK) Brittle & fragile nails, hair loss, poor wound healing (protein) Low energy, headache (glucose) Sclera of eye is white and not the usual pink (iron)
66
Why is it essential to assess swallowing ability?
Difficulty swallowing food/fluids (dysphagia) Choking potential Risk for aspiration into the lungs (aspiration pneumonia)
67
Why is it essential to assess swallowing ability?
Difficulty swallowing food/fluids (dysphagia) Choking potential Risk for aspiration into the lungs (aspiration pneumonia)
68
Therapeutic diets are modified for
Nutrients (ex. chronic conditions) Texture (swallowing concerns) Food allergies or food intolerances
69
A swallow screen for dysphagia should be given before
Giving the patient food, drink, or medication
70
Prior to starting a swallow screen for dysphagia you should
Have oral suction immediately avalible See that the mouth is clean and moist
71
In order to advance the diet you must have
A HCP or MD order
72
When contemplating advancing a diet what should you be assessing/identifying
Assessing for alertness, gag reflex, GI assesment Identify the type of surgery, procedure or anesthesia
73
When advancing a diet why is it important to know if a patient had anesthesia?
could make the patient nauseous resulting in them not wanting to eat Could make the GI track “be not awake” resulting in vomiting or aspiration
74
NPO except meds
Nothing by mouth except meds and the water needed to swallow the meds
75
Postive flatus
Passing gas
76
Clear liquid diet
Broth, fruit juices (apple, cranberry, grape), water, black coffee, tea, popsicles, carbonated beverages, gelatin
77
Full liquid diet
Includes all things liquid as well as any food items that are liquid at room temperature Juices with pulp, out, milk, milkshakes, ice cream, cream soups, uddings, custard, plain yogurt, tritional supplements (May need oral supplementation if for longer then 3 days)
78
Regular diet
Includes all foods and liquids May need to be modified to iadress chewing and swallowing issues Such as mechanical soft, pureed, dysphasiga diets Diet may be modified after speech therapy
79
What is the traditional Hispanic diet
Traditional foods prepared with lard High prevalence of DM; sugary drinks; high Na+/fat Belief in ‘hot‐cold’ to provide balance Recommend boiling, grilling, or healthier oils
80
Traditional Asian diet
Foods are more plant‐based Protein consists of beans, nuts; occasional poultry Lower incidence of CVD, DM, & obesity Prefer hot or warm water May be lactose intolerant
81
Traditional Indian diet
Prefer home cooked foods; wide array of spices Meats election based on religious preference Muslims may not eat pork Buddhists maybe vegetarian
82
Pharmacology
The study or science of drugs How various dosage forms influence the way in which the drug effects the body
83
Pharmaceutics
preparing and dispensing drugs; incl. dosage form design
84
The form of a drug determines
the rate of drug dissolution and absorption
85
Out of all the oral drug preparations what is the order from fastest to slowest of drug absorption
Buccal, SL Liquids, syrups Capsules Tablets Enteric coated tablets
86
What is extended release
release of drug molecules over a prolonged period
87
What are some details about extended relase
prolongs drug absorption • granules in capsules and dosage forms identified by capital letters (CR, SA, XL, XT, CD, TR, ER, LA) • requires fewer doses, improved compliance • cannot be crushed or chewed (possible toxicity)
88
SR
Slow release or sustained release
89
SA
Sustained action
90
CR
Controlled release
91
XL
Extended length
92
XT
Extended time
93
Pharmacokinetics
The study of what happens to a drug from the time it is put into the body until the parent drug and all other metabolites have left the body (Drug absorption, distribution, metabolism, and excretion)
94
What is a drug
Any chemical that affects the physiologic processes of a living organism
95
Chemical name
Describe the drug’s chemical composition and molecular structure
96
Generic name
Nonproprietary name, often much shorter and simpler then the chemical name
97
Drug classsification
Drugs are grouped together based on their similar properties, can be classified by therapeutic use or their structure
98
Toxicology
The study of the adverse effect of drugs and other chemicals on living systems
99
Dosage form determines
The rate at which drug dissolution (dissolving of solid dosage forms and their absorption)
100
A drug to be ingested orally may be in what form
Solid: tablet, capsule, or powder Liquid form: solution or suspension
101
Parental forms
Dosage forms that are administered via injection, need certain characteristics to be safe and effective bc arteries and veins that carry drugs throughout the body they can be easily damaged if the drug is too concentrated or corrosive (100% absorption is assumed immediately after injection)
102
Topically applied dosage forms
Work directly on the surface of the skin
103
Absorption
The movement of a drug from its site of administration into the bloodstream for distribution to the tissues
104
Bioavailability
Term used to express the extent of drug absorption (Passing through the liver effects this bc drug is changed into inactive metabolites)
105
First pass effect
Reduces the bioavailability of the drug to less than 100% (Happens to drugs administered by the mouth not IV)
106
What are the basic routes of drug administration
Enteral, parental, and topical
107
What factors can alter the absorption of drugs
Acid changes within the stomach Absorption changes within the small intestine Presence or absence of food or fluid
108
What factors could effect acidity of the stomach
Time of day Age of the patient Presence and types of medications food and beverages
109
Enteric coating is designed to
Protect the stomach by having drug dissolution and absorption occur in the intestines
110
What could happen if you take an enteric coated medication with a large amount of food
Cause it to be dissolved by acidic stomach contents and therefore reduce intestinal drug absorption
111
What drugs are more easily broken down in an acidic environment
Fat soluble drugs (Presence of food may enhance absorption)
112
What would happen if blood flow to the GI tract is reduced? What could cause this
The stomach and small intestine are highly vascularized, when blood flow is reduced in situations like exercise or sepsis then absorption is decreased
113
Drugs admistered by the sublingual route and buccal route
Are absorbed rapidly by the highly vascularized tissue under the tongue and by the cheek and gum, bypass the liver, are systemically bioavailible
114
Parental route
The fastest route by which a drug can be absorbed Could be IM, IV, or subcutaneous (Bypass the first pass effect of the liver)
115
Subcutaneous injections
Injections into the fatty subcutaneous tissues under the dermal layer of the skin
116
Intradermal injections
Injections under the more superficial skin layers immediately underneath the epidermal layer of skin and into the dermal layer
117
Intramuscular injections
Injections given into the muscle below the subcutaneous fatty tissue (Absorbed faster then subcutaneous bc muscle has greater blood supply then skin)
118
What can you do to the injection cite to increase absorption
Apply heat or massage the site
119
What could reduce drug activity by reducing drug delivery to the tissues
Presence of cold, hypotension, poor peripheral blood flow that compormises circulation
120
Topical route
Involves application of medications to various body surfaces Onset slower, duration longer Can be applied to skin, eyes, ears, nose, lungs, rectum, or vagina Avoid first pass effect (unless rectum)
121
What are examples of topical medications
Ointments, gels, patches, drops, inhalers
122
Oral drugs are absorbed by
Stomach or intestine
123
Oral drug bioavailability is
Less then 100%
124
IV drug avalibility is
100%
125
Subcutaneous bioavalibility is
Close to 100 %
126
Distribution
Refers to the transport of a drug by the blood stream to its cite of action
127
Where are drugs distributed to first
Areas with extensive blood supply (Heart, liver, kidneys, brain)
128
Where are the areas of slower distribution
Skin, muscle, and fat
129
When does elimination of a drug begin
As soon as the drug enters circulation (enters the blood stream) it starts to be eliminated by organs that metabolize and excrete drugs (primarily liver and kidneys)
130
If a drug needs to reach their site of action in extravascular tissue
(Outside the blood vessel) it must be not bound to protein otherwise drug complex would be too large to pass through the walls of the capillaries into the tissues
131
Albumin is
The most common blood protein and caries the majority of protein bound drug molecules
132
free drug
Not bound to protein The unbound portion of a drug is limited pharmacologically active
133
Bound drug
Drug molecules is bound to protien Pharmacologically inactive
134
What happens if you have low albumin levels
There would be a larger amount of free drug Could result in drug toxicity Could be caused by being malnourished or extensive burns
135
What happens when a patient takes two medications that are highly protein bound?
Medications may compete for binding sites on the albumin molecule Resulting in more free drug Could result in drug drug interaction
136
When does a drug drug interaction occur
When the presence of one drug decreases or increases the actions of another drug that is administered concurrently (given at the same time)
137
Metabolism
(Biotransformation) Involves the biochemical alteration of a drug into an inactive metabolite, a more soluble compound, a more potent active metabolite, or a less active metabolite
138
The liver is most responsible for
The metabolism of drugs
139
Metabolic tissues (other then the liver)
Skeletal muscle, kidneys, lungs, plasma, intestinal mucosa
140
Hepatic metabolism involves
The activity of a very large class of enzymes known as cytochrome P-450 enzymes (P-450 enzymes) these control a variety of reactions that aid in metabolism of drugs
141
Lipid soluble drugs
“Fat loving” (lipophilic) Typically very difficult to eliminate Targeted by P-450 enzymes
142
Water soluble drugs
“Water loving” (hydrophilic) May be more easily metabolized by simpler chemical reactions such as hydrolysis (Prepare for excretion)
143
Prodrug
An inactive drug dosage form that is converted to an active metabolite by various biochemical reactions once it is inside the body *Designed to be activated by the liver
144
Excretion
The elimination of drugs from the body, all drugs must eventually be removed from the body
145
Primary organ in excretion
The kidneys
146
When drugs reach the kidneys
They have already gone through extensive biotransformation and only a relatively small fraction of the original drug is excreted as the original compound
147
What happens to drugs when they are metabolized by the liver
They become more polar and water soluble
148
Biliary excretion
Excretion of drugs by the intestines Drugs will be taken up by the liver, released into the bile, and eliminated in the feces
149
Enteral drugs also include (Ones that do not undergo first-pass effect)
ODTs -Orally disinegrating tablets Oral soluble films Sublingual Buccal (transmucosal)
150
Rectal drugs
used for both local and systemic delivery may be considered enteral or topical mixed first-pass and non-first-pass absorption and metabolism
151
What does the liver want to do
Biotransformation: Change drug from lipid soluble to water soluble Decrease drug molecules Inactivate drug molecules
152
What problems could effect excretion, why could this be problmatic
Kidney disease or kidney failure They are at risk for toxicity
153
What routes are first pass effect
Oral Rectal
154
What routes are non first pass effect
Inhaled IV Sublingual Intranasal IM Subcutaneous Transdermal Rectal
155
Is Intranasal first pass or non first pass, why
Non first pass bc it goes to the lungs and moves directly into the bloodstream
156
Half life of a drug
The time required for on half of a given drug to be removed from the body
157
Drug effects
Are the physiologic reactions of the body to the drug (Onset, peaks, duration, and trough all describe the drug effect)
158
A drug’s onset of action
The time required for the drug to elicit a therapeutic response
159
A drug’s peak effect
The time required for a drug to reach its maximum therapeutic effect
160
A drug’s duration of action
The length of time that the drug concentration is sufficent to elicit a therapeutic response (Without more doses)
161
What is peak level & trough level
Peak is highest blood level Trough is lowest blood level
162
Steady state
The physiologic state in which the amount of drug removed via elimination is equal to the amount of frug absorbed with each dose (Determined by half life of a drug)
163
What could happen if peak blood level is too high
Drug toxicity may occur
164
What is mild drug toxicity and an example
Intensification of effects Ex. excessive sedation
165
What could severe drug toxicity do
Damage vital organs bc of excessive drug exposure
166
What could happen if trough blood levels are to low
Drug may not be at therapeutic levels to create response
167
Pharmacodynamics
Relates to the mechanisms of drug action in living tissues, drug induced normal physiological functions
168
Therapeutic effect
A positive change in faulty physiologic system (Goal of drug therapy)
169
What can a drug do once its at the cite of action?
It can modify the rate at which that cell of tissue functions (increase or decrease) or it can modify the strength of function of that cell of tissue *can not cause a cell or tissue to perform function that is not part of its natural physiology
170
What are the ways drugs can exert their actions
Receptors Enzymes Nonselective interactions
171
Mechanism of action
Effect based on characteristics of cells or tissues targeted by the drug
172
Receptor
A reactive site on the surface or inside of a cell Once a drug binds to a receptor a pharmacologic response is produced (if that is the mechanism of action)
173
Affinity
The degree to which a drug attaches to and binds with a receptor The drug with the “best fit” will have the strongest affinity for the receptor and will elicit the greatest response
174
Agonist
Drug binds to the receptor, there is a response
175
Partial agonist
Drug binds to the receptor, the response is diminished compared with that elicited by an agonist
176
Antagonist
Drug binds to the receptor, there is no response. (Drug prevents binding of agonists)
177
Competitive antagonist
Drug competes with the agonist for binding to the receptor, if it binds there is no response
178
Noncompetitive antagonist
Drug combines with different parts of the receptor and inactivates it, agonist then has no effect
179
Pharmacotherapy What are the classifications
Use of drugs to prevent or treat diseases (Therapeutic and pharmacologic classifications)
180
Therapeutic examples of drugs
Antibiotics Antidiabetics Antihypertensives
181
Pharmacologic examples of drugs
Calcium channel blocker ACE inhibitor Beta-blocker
182
What food has a interaction with Warfrin
Leafy green veggies increase could make the anticoagulant effect decrease
183
Grape fruit juice has an interaction to what medications, why
Cardiac medications, antiseizure, anti cholesterol, antianxiety Causes problems with their enzymes and transporters which leads to too much or too little drug
184
CNS depresents have interactions with what food, what could happen
Valerian root Can increase drowsiness and sedation
185
Polypharmacy
The simultaneous use of multiple medications As the # of meds a person takes increases so does the risk for ADRs
186
Prescribing cascade
When drugs are prescribed specifically to counteract the adverse effect of other drugs
187
Appropriate drug dosages for older adults may be
1/2 or 2/3 less than the standard adult dose (Best to start low and go slow)
188
Aging effects on the cardiovascular system and pharmacokinetics
Decrease cardiac output = decrease absorption & distribution Decrease blood flow = decrease absorption & distribution
189
Aging effects on the gastrointestinal system and pharmacokinetics
Increase pH (alkaline gastric secretions) = altered absorption Decreased peristalsis = delayed gastric emptying
190
Aging effects on the hepatic system and pharmacokinetics
Decrease enzyme production = decrease metabolism Decrease blood flow = decrease metabolism
191
Aging effects on the renal system and pharmacokinetics
Decrease blood flow = decrease excretion Decrease function = decrease excretion Decrease GFR= decrease excretion
192
Kidney function is assessed by measuring
Serum creatine, blood urea nitrogen levels (lab work)
193
Liver function is assessed by
Testing the blood for liver enzymes
194
What are the functions of proteins
Tissue building Immune system function Fluid balance Acid base balance Secondary energy source
195
Why does calcium recommendations increase for older adults
To reduce bone loss and bone fractures
196
The nurse understands that drugs exert their actions on the body by what process
Interacting with receptors Altering metabolic chemical processes Inhibiting the action of a specific enzyme
197
The nurse knows that which factors will affect the absorption of orally administered medications
Time of day pH of the stomach Form of drug preparation Presence of food in the stomach
198
Constipation in a patient with heart failure you should assess their meds to see if they’re on what
Calcium channel blockers