exam 2 Flashcards
0
Q
cephalosporins
A
ICWS
1
Q
penicillins
A
ICWS
2
Q
monobactams
A
ICWS
3
Q
carapenems
A
ICWS
4
Q
vancomycin
A
ICWS
5
Q
fosfomycin
A
ICWS
6
Q
bacitracin
A
ICWS
7
Q
aminoglycosides
A
30s inhibitor
8
Q
tetracycline
A
30S inhibitor
9
Q
glycylcyclines
A
30S inhibitor
10
Q
macrolides
A
50S inhibitor
11
Q
ketolides
A
50S inhibitor
12
Q
streptogramin
A
50S inhibitor
13
Q
oxazolidinones
A
50S synthesis
14
Q
“broad spectrum”
A
50s inhibitors
15
Q
fluoroquinolones
A
DNA gyrase
16
Q
metronidazole
A
DNA fragmentation
17
Q
nitrofurantoin and methenamine
A
DNA damage
18
Q
sulfonamide
A
folic acid metabolism
19
Q
daptomycin
A
binds to membrane and depolarizes it
20
Q
mupirocin
A
binds to tRNA synthase
21
Q
polypeptide antibiotics
A
binds to G- cell membrane phospholipids
22
Q
isoniazid
A
inhibits synthesis of mycolic acid
23
Q
rifampin
A
inhibits DNA dependent RNA polymerase
24
ethambutol
inhibits arabinosyl transferase
25
pyrazinamide
unknown mechanism
26
streptomycin
30S inhibitor
27
Dapsone
interferes w/ folic acid metabolism
28
amphotericin B
cell wall inhibitor
29
Azoles
cell wall inhibitor
30
echinocandins
cell wall inhibitors
31
Flucytosine
metabolic antagonism of fungal DNA and RNA
32
griseofulvin
binds microtubules
33
terbinafine
interferes w/ sterol biosynthesis
34
oral penicillinase resistant penicillins
Dicloxacillin
| Oxacillin
35
oral 1st gen cephalosporin
cephalexin
36
oral 2nd gen cephalosporins
ceflacor
| cefprozil
37
oral 3rd gen cephalosporins
cefixime
38
drug w/ MAOI side effects
linezolid
39
monobactam spectrum
aerobic G- rods
40
carapenem spectrum
G+, G-, aerobes, anaerobes
41
aminoglycoside spectrum
aerobic G- enteric rods
42
tetracycline spectrum
G+, G-, anaerobes, aerobes, atypicals
43
macrolide spectrum
G+
44
ketolide spectrum
broad
45
fluoroquinolone spectrum
aerobic G- rods w/ G+ coverage as well
46
polypeptide antibiotic spectrum
G-
47
mupirocin spectrum
G+, some G-
48
cephalosporin toxicity risk
nephrotoxicity
49
carapenem risk
imipenem and cilstatin- seizure risk
50
vancomycin toxicities
ototoxicity
| nephrotoxicity
51
bacitracin toxicity
parenteral- nephrotoxicity
52
fluoroquinolone toxicities
increased QT interval
| cartilage issues
53
sulfonamide toxicities
SJS
| kernicterus- not for infants
54
polypeptide antibiotic toxicity
nephrotoxic, use only topically
55
cephalosporins w/ CNS penetration
Ceftriaxone
| Cefotaxamine sodium
56
tx for osteomyelitis
clindamycin
57
only drug w/ 100% CNS penetration
Chloramphenicol
58
the only bacteriocidal protein synthesis inhibitor
aminoglycoside
59
which drugs interfere with the P450 system?
erythromycin
rifampin
ketoconazole
60
drugs that elevate liver enzymes
caspofungin
| flucytosine
61
antifungals w/ CSF penetration
fluconazole
| flucytosine
