Exam 2 Koh- Retina Biochem 2 Flashcards Preview

Anatomy and Biochemisty > Exam 2 Koh- Retina Biochem 2 > Flashcards

Flashcards in Exam 2 Koh- Retina Biochem 2 Deck (30):
1

Functional role of retinol

Transport

2

Functional role of retinal

Visual transduction

3

Functional role of retinoic acid

Synthesis

4

Functional role of retinyl ester

Storage

5

What are isomerase and ARAT coupled as?

Isomerosynthase

6

What are absent in Mueller cells?

LRAT and RPE65

7

What gene is retinitis pigmentosa associated with?

RGR and RHO

8

What gene is fundus albipunctatus associated with?

RDH5

9

What gene is leber congenital amaurosis associated with?

RPE65 and EDH12

10

What gene is leber congenital amaurosis associated with?

LRAT

11

What gene is Stargardt disease and macular degeneration associated with?

ABCA4

12

What do mutations in RPE65 cause?

LCA and severe recessive RP

13

What is the difference in the speed of the photoresponse between rods and cones?

Rod is sensitive, but slow; cone is noisier but fast

14

Rods are for ______ resolution; cones are for ______ resolution

Temporal, spatial

15

What is the peak absorption rate of the blue cone?

437 nm

16

What is the peak absorption rate of the rod?

498 nm

17

What is the peak absorption rate of the green cone?

533 nm

18

What is the peak absorption rate of the red cone?

564 nm

19

Only ___ morphological type of bipolar cell connects with the rod photoreceptors

One

20

The invaginating contact bears metabotropic _______ receptors in the rod bipolar dendrite membrane

Glutamate

21

The output of the rod bipolar ribbon is to what?

A dyad of amacrine

22

Ganglion cells with dendrits in sublamina a respond to light how?

With a hyperpolarizing or OFF-center response

23

Ganglion cells with dendrits in sublamina b respond how?

With a depolarizing or ON-center response

24

Rod bipolar is interconnected by what?

A17 amacrine cell

25

What are the 2 type of glutamate receptors?

OFF-bc: AMPA-kainate (iGluR) and ON-bc:mGluR6, Go

26

What is an OFF-center cell?

Sublamina a (outer part of retina)

27

What is an ON-center cell?

Sublamina b (inner part of retina)

28

Cone bipolar cells ______ synapses with ganglion cell

Directly

29

Horizontal cells facilitate _____ inhibition

Lateral

30

How many types of ganglion cells are there?

More than 20