EXAM 2 LOs Section 1

Question 1

Define the terms pharmacology, pharmacodynamics, pharmacokinetics.

Answer 1

Pharmacology: Science of interactions of chemical compounds w/ biological systems.
Pharmacodynamics: study of biochemical & physiological effects of drugs and the mechanisms of their actions.
Pharmacokinetics: study of absorption, distribution, biotransformation, and elimination of xenobiotics. (what drug does in the body)

Question 2

describe characteristics of drugs

Answer 2

drugs are defined by actions (agonists & antagonists)
most act on receptors (exceptions include chemical antagonists)
endogenous hormones (hormones or neurotransmitters or xenobiotics)
includes poisons/toxins “the dose makes the person”
solids, liquids, gases
covalent, electrostatic, and hydrophobic interactions
drug design for receptor

Question 3

identify sites of drug action

Answer 3

drug receptor is the cornerstone of pharmacology
agonist: is the drug whose interaction with the receptor stimulates a bio response
orthosteric: agonists, antagonist, partial agonist, and inverse agonist
allosteric: PAM and NAM

Question 4

relate affinity to law of mass action

Answer 4

higher Kon is more affinity
KD is Koff/Kon

Question 5

outline components of receptor binding assays

Answer 5

??

Question 6

principles of receptor binding to measure binding

Answer 6

use

Question 7

use graphical data for pharmacological profiling

Question 8

apply receptor affinity to receptor selectivity

Question 9

describe the relavance of Bmax