Exam 2 - Medchem 753, CVD Succhy Flashcards Preview

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Flashcards in Exam 2 - Medchem 753, CVD Succhy Deck (26)
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1

Define Cardiac Output

Stroke Volume x HR = CO

2

Blood Pressure Equation

CO x Vascular Resistance = BP

3

What Risk factors exist for CVD?

Smoking
Weight
Alcohol
FH
Estrogen Therapy
Age
Diet
Stress
Meds
Activity level
Comorbidities

4

What other disease states can exacerbate CVD?

HTN, HLD, CHF, DM, etc

5

What medications may exacerbate CVD?

Drugs that prolong QT interval
NSAIDS
Etc.

6

What classes of meds are used for HTN?

Beta Blockers
Alpha 1 adrenergic blocker
Alpha 2 agonists
Vasodilators
ACE inhibitors
ARBs
Diuretics

7

What classes of drugs are used for Hyperlipidemia?

Bile acid Sequestrants
Statins
Nicotinic Acids
Fribic acid inhibitors
Cholesterol absorption blockers

8

What medications are used to treat Arrhythmia?

Na channel blockers
Beta Blockers
K channel Blockers
Ca channel Blockers

9

What medications are commonly given to Heart Failure patients

ACE inhibitors
ARBs
Diuretics
Beta Blockers
CCBs
Aldosterone Antags
Digoxin
Vasodilators
Inotropics

10

What medications are commonly given to Cardiac Arrest Patients?

Sympathomimetics
Anti-arrhythmics
Magnesium

11

What medications are commonly prescribed for Acute Coronary Syndrome?

Aspirin
Anti-platelet
Oxygen
Morphine
Nitroglycerin
Fibrinolytics
GP IIb/IIa inhibitors
Anticoags
Beta Blockers

12

What Medications are used for Ischemic Heart Disease?

BBs
CCBs
Nitrates

13

What medications are commonly used for Stroke treatment?

Tissue Plasminogen Activator
Aspirin

14

What medications are commonly used for Peripheral Artery Disease?

Anti-platelet
Cilostazol
Pentoxifylline

15

What is the effect of alpha 1 adrenergics on g cell?

(Gaq)
increase phospholipase C
Increase IP3, DAG and Ca

16

What is the effect of alpha 1 adrenergics on blood vessels in dermal, GI, bladder and nasal membranes?

constriction of smooth muscle

17

What are the primary effects of Alpha 1 adrenergics on the eye, bladder and GI sphincters

constriction (inc peripheral resistance and inc diastolic BP), Eye Mydriasis, constipation (dec outflow)

18

What is the effect of alpha 2 adrenerigcs on g cell?

(Gai)
Dec Adenyl Cyclase
Inc K channels
Dec cAMP

19

Where are the effect of alpha 2 adrenergics often seen?

Eye
Pancreatic Islets
Presynaptic Nerve terminals
CNS
Spinal Cord
Nasal Vasculature

20

What are the primary effects of alpha 2 adrenergics on eye, islets, nerve terminals, CNS and nasal vasculature?

Dec prod of aq humor
Dec insulin release (Inc blood glucose)
Dec NT release
Dec BP, inhibit Baroreflex
Inhibit pain
constriction

21

What is the effect of Beta 1 on g cell?

(Gas)
Inc Adenyl Cyclase
Inc cAMP
Inc Ca

22

Where are the effects of Beta 1 often seen?

Heart
Kidney
Eye

23

What are the primary effects of B2 on Heart, Kidney and Eye?

Inc HR, Contractility and Force of contraction (Inc CO)
Inc Renin Secretion (Vasoconstriction)
Inc production of aqueous humor

24

What are the effects of Beta 2 on g cell?

(Gas)
Inc Adenyl Cyclase
Inc cAMP
Inc Ca

25

Where are effects of Beta 2 often seen?

Hepatic/Skeletal muscle; vascular smooth muscle
Pulmonary Smooth Muscle
GI longitudinal smooth muscle
Bladder detrusor muscle
Pregnant uterus
Mast Cells
Pancreas
Liver
Eye

26

What are the primary effects of Beta 2 on the:
1. Hepatic/Skeletal muscle, vascular smooth muscle
2. Pulmonary smooth muscle
3. GI longitudinal smooth muscle
4. Bladder Detrusor muscle
5. Myometrium
6. Mast cells
7. Pancreas
8. Liver
9. Eye

1. Relaxation, Inc blood flow, inc. gluycogenolysis, inc. K intake
2. Relaxation, inc Blood Glucose
3. Relaxation, dec motility
4. Relaxation, dec outflow
5. Relaxation
6. Dec Degranulation (inhibition of histamine release)
7. Inc Glucagon secretion
8. Glycogenolysis, Inc Blood Glucose
9. Inc production of aq humor