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Neuropharmacology > Exam 2 Pharmacology > Flashcards

Exam 2 Pharmacology Flashcards

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1
Q

bioterpin

A

glycine transporter 1 antagonist

(increases NMDAR activity since NMDARs need glycine as a co-agonist, potential antipsychotic)

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2
Q

N-methylglycine sarcosine

A

Glycine transporter 1 antagonist

(increases NMDAR activity since NMDARs need glycine as a co-agonist, potential antipsychotic)

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3
Q

glycine, b-alanine, taurine, d and l-alanine, l-serine, d-serine

A

glycine receptor agonists

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4
Q

glycine receptor agonists

A

amino acids: glycine, b-alanine, taurine, d and l-alanine, l-serine, d-serine

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5
Q

strychnine

A

competitive glycine receptor antagonist

a convulsant and pesticide, lethal

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6
Q

picrotoxin and picrotin

A

noncompetitive inhibitors of alpha-homomeric glycine receptors and gaba a receptors

a convulsant, insecticide, antidote for barbituate poisoning in GABAA

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7
Q

cyano-triphenyl-borate (CBT)

A

noncompetitive antagonist of alpha 2 homomeric glycine receptors, use-dependent meaning it binds in the open conformation

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8
Q

vigabatrin

A

blocks gaba transaminase, meaning there is more GABA around

acts as an anticonvulsant

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9
Q

tiagabine

A

GABA transporter inhibitor

anticonvulsant

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10
Q

muscimol

A

GABA A agonist at the GABA site

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11
Q

bicuculline

A

GABAA antagonist at the GABA site

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12
Q

what do benzodiazepines, ethanol, and anaesthetics have in common

A

positive allosteric modulators of GABA A, potentiate GABA A current

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13
Q

benzodiazepines

A

potentiate the gaba a current, making it stronger

anxiolytic, anticonvulsant, sedative, alcohol detox

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14
Q

beta-carboline/ b-cce

A

inverse agonist of GABAA, binding at the benzodiazepine site

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15
Q

flumazenil

A

antagonist of GABAa at the benzodiazepine site, reverses the benzodiazepine overdose, reduces sleepiness

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16
Q

barbituates

A

bind gabaa on the beta subunit, potentiate GABAA current, sedatives/anxiolytics w/ high abuse potential

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17
Q

neurosteroids

A

allopregnanolone, ganaxalone

positive allosteric modulators of GABAa that act as anxiolytics or anticonvulsants

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18
Q

allopregnanolone, ganaxalone

A

positive allosteric modulators of GABAa that act as anxiolytics or anticonvulsants

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19
Q

anaesthetics

A

potentiate gabaA current

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20
Q

desflurane, isoflurane, sevoflurane

A

volatile anasthetics that potentiate gaba A current

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21
Q

propofol

A

intravenous anaesthetics that potentiate the GABA a current

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22
Q

ethanol

A

potentiates the GABAa current and can also weakly antagonize NMDARs

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23
Q

baclofen

A

gaba b agonist

a muscle relaxant for spastic movement disorders and maybe alcoholism

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24
Q

3-APPA

A

gabab agonist

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25
phaclofen
gabab r antagonist
26
nAchr agonists
acetylcholine, nicotine, carbachol, arecoline, coniine
27
turbocurarine
nachr competitive reversible antagonist, active component of curare
28
varenicline
partial agonist at nachr receptors, helps with smoking quitting
29
mecamylmine
noncompetitive nachr antagonist
30
alpha-bungarotoxin
nachr antagonist-- competitive and irreversible
31
muscarine
nonspecific agonist of machrs, causes salivation, sweating, tearing, diarrhea, cardiac/respiratory failure antidote is atropine
32
muscarinic agonists
muscarine, arecoline, oxotremorine, carbachol, pilocarpine
33
tabun and sarin
gas acetylcholinesterase inhibitors
34
diazinon
ache inhibitor
35
carbamates and carbamyl
reversible covalent ache inhibitors
36
physostigmine, rivastigmine, neostigmine
carbamate ache inhibitors, riva used for cns but neo isnt
37
galantamine
ache inhibitor for dementia
38
tacrine
ache inhibitor for dementia
39
donzepil
ache inhibitor for dementia
40
atropine
nonspecific competitive machr antagonist that counteracts muscarine and ache inhibitor poisoning reduces salivation and diarrhea, counteracts bradycardia
41
benzatropine
nonspecific competitive machr antagonist, reduces parkinsonism and tremors
42
ampa receptor agonists
ampa, quisqualate, fluorowillardiine
43
quisqualate
ampar agonist, also group 1 mglur agonist
44
fluorowillardiine
ampar agonist
45
nbqx
ampar competitive antagonist
46
cnqx
ampar competitive antagonist
47
dnqx
ampar competitive antagonist
48
quinoxaline family
ampar competitive antagonist-- NBQX, CNQX, DNQX
49
tofisopram
noncompetitive antagonist of AMPAr 2,3 benzodiazepine anticonvulsant, neuroprotective
50
2,3 benzodiazepines
noncompetitive antagonist of ampar anticonvulsant, neuroprotective
51
iem 1460, spermine, philanthotoxin 74
bind glua2 lacking ampars, which can pass calcium they block the ampa4 calcium current, and spermine helps give inward rectification to potassium channels this is important because we can compare calcium passing and noncalcium passing channels
52
cyclothiazide
blocks desensitization of AMPARs a positive allosteric modulator
53
ampakines
positive allosteric modulators of AMPA receptors. usually have CX and a number can be nootropic
54
aniracetam and piracetam
racetams that act as ampakines ampakines are positive allosteric modulators of AMPA receptors
55
benzylpiperidines
ampakines they are positive allosteric modulators of AMPA receptors.
56
families of drugs that are ampakines
racetams and benzylpiperdines
57
cycloserine
partial NMDAR agonist at the glycine site may help with cognitive symptoms of schizophrenia
58
aspartic acid
NMDAR agonist at the glutamate site
59
NMDAR agonists
NMDA, aspartic acid, cycloserine
60
AP5
antagonist at glutamate site of NMDAR
61
5,7 DCK
antagonist at glycine site of NMDAR
62
MK801, Ketamine, PCP
use-dependent channel blockers of NMDARs bind the open conformation, anesthetic, dissociative/hallucinogenic
63
s-mcpg
mglur antagonist
64
ACPD
mglur agonist for all families
65
phenylglycines
family of mglur antagonists
66
dhpg
group 1 mglur agonist
67
mcpg
mglur group 1 antagonist
68
aida
group 1 mglur antagonist
69
cpccoet
mglur type 1 channel 1 noncompetitive antagonist
70
mpep
mglur type 1 channel 5 noncompetitive antagonist
71
mavoglurant
mglur type 1 channel 5 noncompetitive antagonist failed fragile x clinical trials
72
map4
group 2 and 3 mglur antagonist
73
elgumegad and dcg iv
group 2 mglur agonist addiction, anxiety, neuroprotective
74
eglu, pccg4
group 2 mglur antagonists
75
biphenylinadone A
positive allosteric modulator of group 2 mglur anxiolytic, may be antipsychotic
76
l-ap4
mglur group 3 agonist
77
mppg
mglur group 3 antagonist
78

Neuropharmacology (2 decks)

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