Exam 2 Reverse Flashcards
(299 cards)
Serum level dec. but total body sodium normalSevere1. Hyperglycemia2. Hyperproteinemia3. Hyperlipidemia
What is psuedohyponatermia & causes?
<113 - seizures & coma High mortality w/ CNS findings
S/S Hyponatremia
True hyponatremia - osmolality decFactitious hyponatremia - osmolality normal or inc.
Dx hyponatermia
Osmotic pressure >295MCC hyperglycemiaEach 100mg/dL inc. in glc dec. serum sodium by 1.7 due to water moving into ECF
Hypertonic hyponatermia
Osmotic pressure 275-295High proteins & lipids cause a lab to report a falsely lowered sodium than what the serum actually contains
Isotonic hyponatremia
Osmotic pressure >275 Hypovolemic - loss of Na & waterEuvolemic - normal volume statusHypervolemic - excess total body water
Hypotonic hyponatremia
Hypovolemic hyponatremiaUrinary sodium >201. Diuretics2. Renal tubular acidosis, chronic renal failure, nephritis3. Osmotic diuresis4. Addison’s
Causes of renal losses of sodium
Hypovolemic hyponatremiaUrinary sodium <201. Vol replacement w/ hypotonic fluids2. GI loss (V/D, tube suction)3. 3rd space loss (burns, peritonitis, pancreatitis)4. Sweating (CF)
Causes of extrarenal losses of sodium
Urinary sodium >201. SIADH - tumors, CNS disease, pulm disease, meds, idiopathic2. Hypothyroid3. Pain, stress, psychosis - stimulates ADH4. Drugs - carbamazepine, phenothiazines, TCAs5. Water intoxication6. Glucocorticoid deficiency
Euvolemic hyponatremia
Volume overload Urinary sodium >20 - renal failureUrinary sodium <20 - CHF, cirrhosis, nephrotic syndrome
Hypervolemic hyponatremia
Hypervolemic or euvolemic hyponatremia - fluid restriction SIADH - demeclocycline or furosemideHypovolemic hyponatremia - isotonic saline
Tx hyponatremia
Central pontine myelinolysis brain injury
What can happen if you correct hyponatremia too rapidly?
Give 3% hypertonic saline at 25-60 mL/hrDo not raise Na >2mEq/L/hrStop when sodium reaches 120 or when Pt improves
Acute Hyponatremia <120 w/ CNS Sx - how do you treat?
Correction of Na no more than 0.5 mEq/L/hr
Tx chronic hyponatremia
- Na <1252. Require IV3. Significant comorbidities
When do you admit hyponatremia Pts?
Na >1501. Reduced water intake2. Inc. water loss - hypervent., DI, osmotic diuresis, thyrotoxicosis, severe burns3. Inc. sodium intake/renal salt retention - hypertonic saline ingestion, sodium bicarb, hyperaldosteronism, Cushing’s
Hypernatremia causes
Usually at Na>158 - rate of change important1. Confusion, weakness, irritable, restless, tremulous, seizures, coma2. Hypocalcemia may be present causing CNS Sx3. Flat neck veins, orthostatic HOTN, tachycardia, poor skin turgor, dry mucous membranes
Sx hypernatremia
Severe dehydration - NS or LR Then 0.45% saline Sodium reduction should not exceed 15mEq/L/day Reach normal serum sodium in 48-72hrs
Tx hypernatremia
5-Mar
You lose 1L of water, how much does your serum sodium increase?
Hypokalemia - <3.5
What is the MC electrolyte abnormality?
- Extrarenal - inadequate intake, V/D, inc. insulin, alkalosis2. Renal - diuretics, aldosteronism, renal tubular acidosis3. Lithium, heavy exercise, heat stroke, fever
Causes of hypokalemia
- Weakness, paresthesias, polyuria, orthostatic HOTN, areflexia, ileus, arrhythmias 2. EKG - T wave flattening/inversion, U waves, ST depression, PVC’s, wide QRS, tachyarrhythmias Want to get CK, Mg, UA, BMP
S/S hypokalemia
K>2.5 w/o EKG findings - oral replacement daily until normalK<2.5
Tx hypokalemia
K >5.5 1. Factitious - release of intracellular K by hemolysis during phlebotomy2. Extrarenal causes - insulin deficiency, acidosis, hyperosmolality, beta-blockers, supplements, massive transfusion, crush injuries, burns, mesenteric or muscle infarction 3. Renal causes - chronic renal insufficiency, acute renal failure, hypoaldosteronism, drugs (NSAIDs, ACEi, K-sparing diuretics)
Hyperkalemia causes