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ADN 120 > EXAM 3 > Flashcards

EXAM 3 Flashcards

(50 cards)

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1
Q

buspirone use

A

chronic anxiety
safe for regular scheduled use

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2
Q

buspirone MOA

A

binds to serotonin and dopamine receptors in brain

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3
Q

buspirone side effects

A

tachycardia
palpitations
paradoxical anxiety
HA
blurry vision
dizziness
nausea
poor coordination

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4
Q

buspirone considerations

A

non-habit forming
taper
assess hx substance abuse
needs to be taken daily
optimal results take 3-4 wks
drug interaction w/SSRI- serotonin syndrome
lg amounts grapefruit increased effect
do not give with MAOIs

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5
Q

Benzodiazepines MOA

A

decreases CNS activity
enhances GABA

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6
Q

Benzodiazepines Side Effects

A

risk for dependence
sedation
hypotension
impact on psychomotor abilities
dry mouth
dizziness
confusion
headache

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7
Q

Benzodiazepines considerations

A

assess LOC
med hx
risk for falls
avoid abrupt withdrawal
additive effect with other CNS depressants

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8
Q

Benzodiazepines meds

A

alprazolam, diazepam, lorazepam

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9
Q

alprazolam

A

GAd- short term use, oral contraceptives increase effectivness

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10
Q

diazepam

A

anxiety, ETOH withdrawl, status epilepticus, adjuvant for muscle spasm
oral contraceptives can increase effectivness

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11
Q

Lorazepam

A

IVP, continuous IV for severely agitated pts. ETOH withdrawal
status epilepticus IV and IM
oral contraceptives decrease theraputic effectivness

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12
Q

SSRI meds

A

fluoxetine, citalopram, sertraline, escitalopram

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13
Q

SSRI use

A

depression, bipolar, PTSD

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14
Q

SSRI MOA

A

blocks reabsorption of serotonin by nerve cells

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15
Q

SNRIs meds

A

duloxetine, venlafaxine

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16
Q

SNRI use

A

depression, GAD, adjuvant pain

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17
Q

SNRI MOA

A

blocks reabsorption of serotonin and norepinephrine in CNS

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18
Q

Miscellaneous meds

A

bupropion- NDRI, mirtazapine- tetracycline antidep.

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19
Q

bupropion use

A

depression/ SAD

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20
Q

bupropion action

A

decreased neuronal reuptake of dopamine in CNS, diminished neuronal uptake of serotonin and norepinephrine

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21
Q

mirtazapine- tetracycline antidep. use

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A

depression, eating disorders, substance abuse

22
Q

mirtazapine- tetracycline antidep. action

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A

increase effectivness/ norepinephrine and serotonin, and dopamine

23
Q

mirtazapine-tetracycline antidep. SE

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A

weight gain, increased suicidal thoughts

24
Q

Second- Generation Antidepressants meds

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A

SSRIs, SNRIs, miscellaneous (bupropion, mirtazapine- tetracycline)

25
Second- generation antidep. SE
insomnia weight gain anxiety dizziness drowsiness sexual dysfunction discontinuation syndrome
26
second generation antidep. interactions
with other highly protein bound drugs will compete for binding sites increased bleeding risk with anticoagulans/ NSAIDs other serotonin enhancing drugs/ herbs will increase risk of serotonin syndrom ETOH increased risk MAOI increased risk, over counter cold meds icnrease risk
27
First-Generation anitdepressant
tricyclic antidepressants (TCAS)
28
TCAs meds
amitriptyline
29
TCA use
depression, childhood enuresis, adjuvant analgesics for chronic pain conditions, neuropathic pain
30
TCAs MOA
potentiates effect of serotonin and norepinephrine in CNS
31
TCA SE
sedation suicidal ideation anticholinergic (dry mouth, urinary rention, constipation, blurred vision) dyrhythmias (lethal overdose) impotence orthostatic hypotension ataxia weight gain older patients: monitor closely for over- sedation and profound CNS depression
32
TCA interactions
overdose- highly lethal so specific antidote but can decrease drug absorption with activated charcoal
33
TCA considerations
monotor ECG suicidal ideation weight and BMI before treatment assess fasting glucose urine- blue-green get up slowly taper, 2 wk washout for surgery given if second gen fail
34
MAOIs meds
phenelzine, tranylcypromine
35
MAOIs use
atypical depression
36
MAOI action
accumulate dopamine, epinephrine, norepinephrine, and serotonin in body
37
MAOI SE
dizziness, dykinesias, nausea, syncope, hypertension
38
MAOI interaction
yramine: -Foods or drinks with tyramine leads to hypertensive crises, which may lead to cerebral hemorrhage, stroke, coma, or death. -Avoid foods that contain tyramine: Think Charcuterie board such as aged, mature cheeses (cheddar, bleu, Swiss) Smoked, pickled, or aged meats, fish, poultry (herring, sausage, corned beef, salami, pepperoni, paté) Yeast extracts Red wines (Chianti, burgundy, sherry, vermouth) Italian broad beans (fava beans)
39
MAOI considerations
require 3-6 wks effective no pregnancy 2 wk washout, taper avoid foods that contain tyramine serotonin syndrome if taking with SSRI
40
selagiline patch
MOAI
41
Selegiline patch use
depression
42
selegiline patch MOA
icnreases dopamine serotonin and noreprinephrine levels in brain
43
selegiline patch SE
nausea, serotonin syndrome
44
selegiline patch interactions
no concerns with food inceractiosn at lower dose
45
Selegline patch considerations
peds, alochol, avoid external heating measures and sunlight
46
St johns wort (herbal product) use
mild/moderate depression anxiety sleep disorders nervousness
47
st. johns wort action
antidepressant action may be due to ability to inhibit reuptake of serotonin and other neurotransmitters
48
st. johns wort SE
generally well tolerated fatigue dizziness confusion dry mouth photosensitivity
49
st. johns wort interactions
MAOI, SSRI, TCA, benzodiazepines, tyramine-containing foods, opioids, oral contraceptives
50
st. johns wort considerations
pregnancy breast feeding peds may cuase insomnia, anxiety, GI issues, headache, sexual dysfunction no bipolar no alzeimers/dementia avoid ETOH

ADN 120 (3 decks)

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