Exam 3

Question 1

Transmitter depleters of NE

dec symp tone, affect adrenergic nerve terminal to dec NT release of NE

Answer 1

Reserpine
Guanethidine

RG3

Question 2

Alpha-2 agonists

inc NTS, dec symp, reverse LVH, dec cholesterol

Answer 2

clonidine
Alpha-methyl dopa

Cl-Alpha

Question 3

Alpha-1 antagonists

block sympathetic tone in vasculature, dec cholesterol

Answer 3

Doxazosin
Prazosin

“-AZOSINS”

Question 4

B-blockers

dec cardiac output, dec force of cardiac contraction, dec renin

Answer 4

“-olols”
non selective: propran, labet
B1 cardio- selective: acebut, aten, metop

Question 5

Saluretics

-initial dec in Na and fluid and BP

inexpensive first line of drug choice

Answer 5

Hydrochlorothiazide
chlorthalidone

-Potassium sparing-
spironolactone
amiloride

“Spiro Ate potassium”

Question 6

Smooth muscle vasodilators

-dec peripheral resistance

Answer 6

Hydralazine
Minoxidil
Nitroprusside

“How many ninjas”

hydras, minotaurs, nitro

Question 7

ACE inhibitors

angiotensin converting enzyme

competitively antagonize conversion of Angio1 to Angio2

inhibit breakdown of bradykinin (vasodilator)

Answer 7

“Pril”

captopril
enalapril
fosinopril

“Cats eat fish”

Question 8

ARBs

competitive antagonists of type 1 angio2 receptor

more effective than ACE since some angio2 can be produced outside the RA pathway

Answer 8

-“Sartans”

losartan
valsartan

LOVA

Question 9

Renin inhibitor

binds renin and inhibit cleavage of angiotensinogen->angiotensin 1

CI PREGNANCY

Answer 9

Aliskiren

Question 10

Calcium channel blocker

produce VSM relaxation and dec peripheral resistance

Answer 10

Nifedipine
verapamil
diltiazem

Niggas very dark

Question 11

PDE5 inhibitor

vsm relaxation

Answer 11

Sildenafil

Question 12

Antiarrhythmic

Class 1A

med recovery

Answer 12

Quinidine
Procainamide

queen proclaims

Question 13

Antiarrhythmic

Class 1B

rapid recovery

Answer 13

Lidocaine
Mexiletine

little mexican

Question 14

Antiarrhythmic

Class 1C

slow recovery, atrial arrhythmia with no deformity/CAST

Answer 14

flecainide
propafenone

flex professionally

Question 15

Antiarrhythmic

Class 3

phase 3, block K+ efflux

• prolong reploarization
• affect nodal/muscle repolarization

Answer 15

Amiodarone
Sotalol
Ibutilide
Dofetilide

Amy sought ibiza dope

Question 16

Cardiotonics-digitalis

-REVERSIBLE INHIBITION OF NA/K ATPase

Answer 16

Digoxin
Digitoxin

Diglet digs

Question 17

Beta 1 agonists

+ inotrope

Answer 17

Dopamine
Dobutamine

dobby dopes

Question 18

Antianginals

Answer 18

nitrates
b blockers
calcium channel blockers

Question 19

Beta 2 agonists

rapid bronchodilation

Long acting beta 2 agonists

taken with corticosteroids when chronic

Answer 19

“-terols”
albuterol
terbutaline

formoterol
salmetrol

asthma trouble from santa

Question 20

Inhaled glucocorticoid/corticosteroid

systemic

Answer 20

Inhaled:
budesonide
fluticasone

systemic:
Prednisone

budding flowers please

Question 21

Muscarinic antagonists

inhibit PSNS

used in combo with b-2 steroids

Answer 21

-“Tropium”

ipratropium
tiotropium

IT

Question 22

Leukotriene antagonists

antagonize immune effects

ie bronchoconstriction, mucus secretion, edema

Answer 22

-Lukast

Montelukast
Zafirlukast

Question 23

Antibodies

reduces serum IgE, pt has to take less steroid

Answer 23

OmalizumAB

ab=antibody

Question 24

Preventive agent

inhalant prophylactic asthma control

Answer 24

cromolyn

Question 25

Fluticasone + salmeterol =??

Answer 25

Advair

Question 26

``` Antiepileptics block sodium inhibit gaba inhibit ca channels inhibit glutamate receptors ```

Answer 26

``` Carbamazepine Gabapentin Lamotrigine Levitiracetam Oxcarbazeine Phenytoin Tiagabine Topiramate Volproic acid zonisamide ``` CGL LOP TTVZ

Question 27

Anti epileptics Benzodiazepines gaba neuronal inhibition

Answer 27

-"Azepams" clonazepam diazepam lorazepam

Question 28

Typical Antipsychotics Block dopamine receptors D2>D1

Answer 28

High potency Fluphenazine Haloperidol Low potency Chlorpromazine

Question 29

Atypical Antipsychotics diverse, useful in Tx resistant pts and noncompliant pts

Answer 29

Clozapine Olanzapine Risperidone Aripiprazole CORA

Question 30

Anxiolytics bind gaba receptors to increase inward cl conductance resulting in membrane hyperpolarization and neuronal inhibition increase affinity of gaba(a) to gaba sedation, anti anxiety, skeletal muscle relaxation, anti convulsant, antergrade amnesia

Answer 30

-"azepams" ``` chlordiazepoxide clonazepam clorazepate diazepam flurazepam lorazepam temazepam ```

Question 31

Benzodiazepine agnoist

Answer 31

zolpidem

Question 32

Benzodiazepine antag

Answer 32

flumazenil

Question 33

Anxiolytic that aids in smoking cessation

Answer 33

buspirone

Question 34

barbituates reversibly depress activity of all excitable tissue potentiate gaba dec voltage gated ca dec glutamate induced depolarizations

Answer 34

phenobarbital | thiopental

Question 35

Tricyclic anti-depressants inhibit NE or Serotonin (5-HT) uptake

Answer 35

``` -pramine or -tryptiline amitryptiline desipramine imipramine nortriptyline ``` amy desires indian norms

Question 36

SSRI's inhibit uptake of serotonin

Answer 36

Citolopram Fluoxetine Paroxetine sertraline city flu plagues sundays

Question 37

SNRIS blocks NE, serotonin

Answer 37

duloxetine velafaxine Dem Vikings

Question 38

MAOIs dec metabolism of amines

Answer 38

phenelzine selegiline Play station

Question 39

antimanic agents

Answer 39

lithium** carbamazepine lamotrigine valproic acid lithium: most specific drug for prophylaxis and tx for bipolar has effect on neurohormonal signal transduction systems