exam 3 Flashcards

(124 cards)

1
Q

Why would a patient with hyperthyroidism be prescribed the drug methimazole (Tapazole)?

To limit the effect of the pituitary on the thyroid

To destroy part of the hyperactive thyroid tissue

To stimulate the pineal gland

To block the production of thyroid hormones

A

To block the production of thyroid hormones

Medical management for hyperthyroidism may include administration of drugs that block the
production of thyroid hormones, such as propylthiouracil or methimazole.

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2
Q

To which diet should a patient with Cushing syndrome adhere?

Less sodium
More calories
Less potassium
More carbohydrates

A

Less sodium

The diet should be lower in sodium to help decrease edema.

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3
Q

A patient has returned to his room after a thyroidectomy with signs of thyroid crisis. During
thyroid crisis, exaggerated hyperthyroid manifestations may lead to the development of the
potentially lethal complication of:

severe nausea and vomiting.
bradycardia.
delirium with restlessness
congestive heart failure.

A

congestive heart failure.

In thyroid crisis, all the signs and symptoms of hyperthyroidism are exaggerated. The patient
may develop congestive heart failure and die

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4
Q

The purpose of the use of radioactive iodine in the treatment of hyperthyroidism is to:

stimulate the thyroid gland.
depress the pituitary
destroy some of the thyroid tissue.
alter the stimulus from the pituitary.

A

destroy some of the thyroid tissue.

Radioactive iodine 131 destroys some of the hyperactive thyroid gland to produce a more
normally functioning gland.

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5
Q

Which precaution(s) should the nurse take when caring for a patient who is being treated with radioactive iodine 131 (RAIU)?

Initiate radioactive safety precautions

Avoid assigning any young woman to the patient

Wait three days after dose before assigning a pregnant nurse to care for this patient

Advise visitors to sit at least 10 feet away from the patient

A

Wait three days after dose before assigning a pregnant nurse to care for this patient

The dose is patient specific and at a very low level. No radioactive safety precautions are necessary
and pregnant nurses can be assigned 3 days after the dose. RAIU is not harmful to nonpregnant
women

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6
Q

What is the postoperative position for a person who has had a thyroidectomy?

Prone
Semi-Fowler
Side-lying
Supine

A

Semi-Fowler

Postoperative management of this patient includes keeping the bed in a semi-Fowler position, with pillows supporting the head and shoulders. There should be a suction apparatus and tracheotomy tray available for emergency use.

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7
Q

What extra equipment should the nurse provide at the bedside of a new postoperative thyroidectomy patient?

Large bandage scissors
Tracheotomy tray
Ventilator
Water-sealed drainage system

A

Tracheotomy tray

There should be a suction apparatus and tracheotomy tray available for emergency use.

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8
Q

As the nurse is shaving a patient who is 2 days postoperative from a thyroidectomy, the patient has a spasm of the facial muscles. What should the nurse recognize this as?

Chvostek sign
Montgomery sign
Trousseau sign
Homanssign

A

Chvostek sign

The spasm of facial muscles when stimulated is the Chvostek sign, an indication of hypocalcemic tetany

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9
Q

patient has undergone tests that indicate a deficiency of the parathyroid hormone secretion. She should be informed of which potential complication?

Osteoporosis
Lethargy
Laryngeal spasms
Kidneystones

A

Laryngeal spasms

Decreased parathyroid hormone levels in the blood stream cause a decreased calcium level. Severe hypocalcemia may result in laryngeal spasm, stridor, cyanosis, and increased possibility of asphyxia.

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10
Q

A 27-year-old patient with hypothyroidism is referred to the dietitian for dietary consultation. What should nutritional interventions include?

Frequent small meals high in carbohydrates
Calorie-restricted meals
Caffeine-rich beverages
Fluid restrictions

A

Calorie-restricted meals

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11
Q

What instructions should be included in the discharge instructions for a 47-year-old
patient with hypothyroidism?

Taking medication whenever symptoms cause discomfort

Decreasing fluid and fiber intake

Consuming foods rich in iron

Seeing the physician regularly for follow-up care

A

Seeing the physician regularly for follow-up care

Regular checkups are essential, because drug dosage may have to be adjusted from time to time.

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12
Q

Howshould the nurse administer insulin to prevent lipohypertrophy?

At room temperature
At body temperature
Straight from the refrigerator
After rolling bottle between hands to warm

A

At room temperature

In fact, it is now believed that insulin should be administered at room temperature, not straight
from the refrigerator, to help prevent insulin lipohypertrophy

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13
Q

A patient with a history of Graves disease is admitted to the unit with shortness of breath. The nurse notes the patients vital signs: T 103 F, P 160, R 24, BP 160/80. The nurse also notes distended neck veins. What does the patient most likely have?

Pulmonary embolism
Hypertensive crisis
Thyroid storm
Cushing crisis

A

Thyroid storm

In a thyroid crisis, all the signs and symptoms of hyperthyroidism are exaggerated. Additionally,
the patient may develop nausea, vomiting, severe tachycardia, severe hypertension, and occasionally
hyperthermia up to 41 C (106 F). Extreme restlessness, cardiac arrhythmia, and delirium may
also occur. The patient may develop heart failure and may die

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14
Q

What is the master gland of the endocrine system?

Thyroid
Parathyroid
Pancreas
Pituitary

A

Pituitary

The pituitary gland, located in the brain, is the master gland of the endocrine system. It has been called the master gland because through the negative feedback system, it exerts its control over the other endocrine glands.

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15
Q

What information should be obtained from the patient before an iodine-131 test?

Presence of metal in the body
Allergy to sulfa drugs
Status of possible pregnancy
Use of prescription drugs for hypertension

A

Status of possible pregnancy

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16
Q

The patient being treated for hypothyroidism should be instructed to eat well-balanced meals including intake of iodine. Which of the following foods contains iodine?

Eggs
Pork
White bread
Skinless chicken

A

Eggs

The hypothyroid diet should be adequate in intake of iodine, in foods such as saltwater fish, milk, and eggs; fluids should be increased to help prevent constipation.

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17
Q

The nurse is caring for a patient who is receiving calcium gluconate for treatment of hypoparathyroid tetany. Which assessment would indicate an adverse reaction to the drug?

Increase in heart rate
Flushing of face and neck
Drop in blood pressure
Urticaria

A

Drop in blood pressure

Indications of an adverse effect of calcium gluconate are dyspnea, bradycardia, and hypotension

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18
Q

The adrenal cortex secretes glucocorticoids. The most important is cortisol. What is it involved in? (Select all that apply

Glucose metabolism
Releasing androgens and estrogens
Providing extra reserve energy during stress
Decreasing the level of potassium in the blood stream
Increasing retention of sodium in the blood stream

A

Glucose metabolism

Providing extra reserve energy during stress

Cortisol is involved in glucose metabolism and provides extra reserve energy in times of stress

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19
Q

Which diagnostic test for diabetes mellitus provides a measure of glucose levels for the previous 8 to 12 weeks?

Fasting blood sugar (FBS)
Oral glucose tolerance test (OGT)
Glycosylated hemoglobin (HbA1c)
Postprandial glucose test

A

Glycosylated hemoglobin (HbA1c)

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20
Q

Which test will furnish immediate feedback for a newly diagnosed diabetic who is not yet under control?

Fasting blood sugar (FBS)
Glycosylated hemoglobin (HgbA1c)
Oral glucose tolerance test (OGTT)
Clinitest

A

Fasting blood sugar (FBS)

Diabetics should do a fingerstick blood glucose level test before each meal and at bedtime each day until their disease is under control. The HgbA1c serum test reveals the effectiveness of diabetes therapy for the preceding 8 to 12 weeks

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21
Q

The patient is a 20-year-old college student who has type 1 diabetes and normally walks each evening as part of an exercise regimen. The patient plans to enroll in a swimming class. Which adjustment should be made based on this information

Time the morning insulin injection so that the peak action will occur during swimming

Delete normal walks on swimming class days.

Delay the meal before the swimming class until the session is over.

Monitor glucose level before, during, and after swimming to determine the need for alterations in food or insulin.

A

Monitor glucose level before, during, and after swimming to determine the need for alterations in food or insulin.

Exercise can reduce insulin resistance and increase glucose uptake for as long as 72 hours, as well as reducing blood pressure and lipid levels. However, exercise can carry some risks for patients with diabetes, including hypoglycemia

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22
Q

What is a long-term complication of diabetes mellitus?

Diverticulitis
Renal failure
Hypothyroidism
Hyperglycemia

A

Renal failure

Long-term complications of diabetes include blindness, cardiovascular problems, and renal
failure.

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23
Q

In diabetes insipidus, a deficiency of which hormone causes clinical manifestations?

antidiuretic hormone (ADH)
follicle-stimulating hormone (FSH)
thyroid-stimulating hormone (TSH)
adrenocorticotropic hormone (ACTH)

A

antidiuretic hormone (ADH)

Diabetes insipidus is a transient or permanent metabolic disorder of the posterior pituitary in
which ADH is deficient.

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24
Q

What should the nurse caution a type I diabetic about excessive exercise?

It can increase the need for insulin and may result in hyperglycemia.

It can decrease the need for insulin and may result in hypoglycemia.

It can increase muscle bulk and may result in malabsorption of insulin.

It can decrease metabolic demand and may result in metabolic acidosis.

A

It can decrease the need for insulin and may result in hypoglycemia.

The patient with diabetes should exercise regularly. Exercise can reduce insulin resistance and increase glucose uptake for as long as 72 hours, as well as reducing blood pressure and lipid levels. However, exercise can carry some risks for patients with diabetes, including hypoglycemia.

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25
The nurse caring for a 75-year-old man who has developed diabetes insipidus following a head injury will include in the plan of care provisions for limiting fluids to 1500 mL a day. encouraging physical exercise. protecting patient from injury. discouraging daytime naps.
protecting patient from injury. The patients need protection from injury because they are often exhausted from sleep deprivation and having to get up frequently at night. Fluids should not be limited and their energy should be preserved
26
The physician orders an 1800-calorie diabetic diet and 40 units of (Humulin N) insulin U100 subcutaneously daily for a patient with diabetes mellitus. Why would a mid-afternoon snack of milk and crackers be given? To improve nutrition To improve carbohydrate metabolism To prevent an insulin reaction To prevent diabetic coma
To prevent an insulin reaction Humulin N insulin starts to peak in 4 hours. The nurse should be alert for signs of hypoglycemia (a less-than-normal amount of glucose in the blood, usually caused by administration of too much insulin, excessive secretion of insulin by the islet cells of the pancreas, or dietary deficiency) at the peak of action of whatever type of insulin the patient is taking
27
The nurse teaching a patient with type 1 diabetes mellitus (IDDM) about early signs of insulin reaction would include information about abdominal pain and nausea. dyspnea and pallor. flushing of the skin and headache. hunger and a trembling sensation
hunger and a trembling sensation The patient should be instructed to notify a member of the nursing staff if any signs of hypoglycemic (low insulin) reaction occur: excessive perspiration or trembling.
28
The nurse discovers the type 1 diabetic (IDDM) patient drowsy and tremulous, the skin is cool and moist, and the respirations are 32 and shallow. These are signs of hypoglycemic reaction; give 6 oz of orange juice. hyperglycemic reaction; give ordered regular insulin . hyperglycemic hyperosmolar nonketotic reaction; squeeze glucagon gel in buccal cavity. hypoglycemic reaction; give ordered insulin.
hypoglycemic reaction; give 6 oz of orange juice Hypoglycemic reaction is due to not enough food for the insulin. Quick acting carbohydratessuch as orange juice or longer acting foods such as milk, crackers, and cheeseare beneficial
29
What instructions should a nurse give to a diabetic patient to prevent injury to the feet? Soak feet in warm water every day. Avoid going barefoot and always wear shoes with soles. Use of commercial keratolytic agents to remove corns and calluses are preferred to cutting off corns and calluses Use a heating pad to warm feet when they feel cool to the touch.
Avoid going barefoot and always wear shoes with soles. Sturdy, properly fitting shoes should be worn. Use of corn removers and heating pads is not beneficial to preserve the health of a diabetics feet
30
The physician prescribes glyburide (Micronase, DiaBeta, Glynase) for a patient, age 57, when diet and exercise have not been able to control type 2 diabetes. What should the nurse include in the teaching plan about this medication? It is a substitute for insulin and acts by directly stimulating glucose uptake into the cell. It does not cause the hypoglycemic reactions that may occur with insulin use. It is thought to stimulate insulin production and increase sensitivity to insulin at receptor sites
It is thought to stimulate insulin production and increase sensitivity to insulin at receptor sites
31
What kind of control mechanism is indicated when increased blood glucose levels stimulate increased secretion of insulin? Control by releasing hormones Control by tropic hormones Negative feedback control Hypothalamus/hypophysis coordination
Negative feedback control
32
What is the most common cause of endocrine disorders? Malignant neoplasm Infection Congenital defect Benign tumor
Benign tumor
33
Choose the statement that applies to type 1 diabetes mellitus Onset often occurs during childhood. Relative insufficiency of insulin or insulin resistance develops. It can be treated by diet, weight control and exercise, or oral hypoglycemics. Complications rarely occur.
Onset often occurs during childhood.
34
Whydoes polyuria develop with diabetes mellitus? Increased thirst and hypoglycemia Ketoacidosis Osmotic pressure due to glucose Diabetic nephropathy
Osmotic pressure due to glucose
35
What is the cause of diabetic ketoacidosis? Excess insulin in the body Loss of glucose in the urine Failure of the kidney to excrete sufficient acids Increased catabolism of fats and proteins
Increased catabolism of fats and proteins
36
What is a precipitating factor for diabetic ketoacidosis? Skipping a meal Anorexia Serious infection Insulin overdose
Serious infection
37
Which of the following may cause insulin shock to develop? Strenuous exercise Missing an insulin dose Eating excessively large meals Sedentary lifestyle
Strenuous exercise
38
Which of the following indicates hypoglycemia in a diabetic? Deep, rapid respirations Flushed dry skin and mucosa Thirst and oliguria Staggering gait, disorientation, and confusion
Staggering gait, disorientation, and confusion
39
Which of the following are signs of diabetic ketoacidosis in an unconscious person? Pale moist skin Thirst and poor skin turgor Deep rapid respirations and fruity breath odor Tremors and strong rapid pulse
Deep rapid respirations and fruity breath odor
40
Immediate treatment for insulin shock may include: administration of bicarbonates consumption of fruit juice or candy. induced vomiting. consumption of large amounts of water.
consumption of fruit juice or candy
41
What causes loss of consciousness in a person with diabetic ketoacidosis? Toxic effects of excessive insulin Excessive glucose in the blood Metabolic acidosis Lack of glucose in brain cells
Metabolic acidosis
42
Which of the following does NOT usually develop as a complication of diabetes? Osteoporosis Nephropathy Impotence Peripheral neuropathy
Osteoporosis
43
Howdomanyoral hypoglycemic drugs act? To replace insulin in patients with insulin-dependent diabetes mellitus (IDDM) To transport glucose into body cells To prevent gluconeogenesis To stimulate the pancreas to produce more insulin
To stimulate the pancreas to produce more insulin
44
Diabetes may cause visual impairment through damage to the lens; this is referred to as: cataracts. macular degeneration. myopia. strabismus
cataracts.
45
Which of the following applies to diabetic macro-angiography? It affects the small arteries and arterioles. It is related to elevated serum lipids. It leads to increased risk of myocardial infarction and peripheral vascular disease. It frequently causes damage to the kidneys
It is related to elevated serum lipids. It leads to increased risk of myocardial infarction and peripheral vascular disease
46
Whyis amputation frequently a necessity in diabetics? Necrosis and gangrene in the feet and legs Lack of glucose to the cells in the feet and legs Severe dehydration in the tissues Elevated blood glucose increasing blood viscosity
Necrosis and gangrene in the feet and legs
47
Atype of diabetes that may develop during pregnancy and disappear after delivery is called temporary maternal diabetes. fetal diabetes. acute developmental diabetes. gestational diabetes.
gestational diabetes.
48
Which one of the following develops hypoglycemia more frequently? Type 1 diabetic patients Type 2 diabetic patients Patients with a poor stress response Patients with a regular exercise and meal plan
Type 1 diabetic patients
49
Which of the following hormonal imbalances causes Addisons disease? Increased glucocorticoids Decreased glucocorticoids Deficit of antidiuretic hormone (ADH) Deficit of T3 and T4
Decreased glucocorticoids
50
Which of the following hormonal imbalances causes diabetes insipidus Increased insulin Decreased glucocorticoids Deficit of ADH Deficit of T3 and T4
Deficit of ADH
51
What is caused by hyperparathyroidism? Hypocalcemia Tetany Bone demineralization Deficit of vitamin D
Bone demineralization
52
What is caused by hypocalcemia due to hypoparathyroidism? Skeletal muscle twitching or spasm Weak cardiac contraction Increased secretion of parathyroid hormone (PTH) Decreased serum phosphate level
Skeletal muscle twitching or spasm Weak cardiac contraction
53
Which of the following applies to acromegaly? It occurs in infants and children. It causes excessive longitudinal bone growth. It results from excessive secretion of growth hormone (GH). It does not change soft tissue growth
It results from excessive secretion of growth hormone (GH)
54
Which of the following may cause goiter? Hyperthyroidism Hypothyroidism Lack of iodine in the diet Pheochromocytoma
Hyperthyroidism Hypothyroidism Lack of iodine in the diet
55
Which signs are typical of Graves disease? Facial puffiness, bradycardia, and lethargy Exophthalmos and tachycardia delayed physical and intellectual development Goiter and decreased basal metabolic rate (BMR)
Exophthalmos and tachycardia
56
Characteristics of Cushings syndrome include all of the following EXCEPT Heavy body and round face Atrophied skeletal muscle in the limbs Staring eyes with infrequent blinking Atrophy of the lymph nodes
Staring eyes with infrequent blinking
57
Which of the following is an effect of long-term glucocorticoid therapy? Decreased secretion from the adrenal cortex gland An increased inflammatory response to irritants Hypotension and poor circulation Increased number of hypersensitivity reactions
Decreased secretion from the adrenal cortex gland
58
Which of the following is an effect of Addisons disease? Elevated blood glucose levels High blood pressure Lowserum potassium levels Poor stress response
Poor stress response
59
What is the most common cause of type 1 diabetes mellitus? Increased glucose production in the liver Destruction of pancreatic cells by an autoimmune reaction Increased resistance of body cells to insulin action Chronic obesity
Destruction of pancreatic cells by an autoimmune reaction
60
Whydoes glucosuria occur in diabetics? Excess ketoacids displace glucose into the filtrate. Excess water in the filtrate draws more glucose into the urine The amount of glucose in the filtrate exceeds the renal tubule transport limit. Sufficient insulin is not available for glucose reabsorption.
The amount of glucose in the filtrate exceeds the renal tubule transport limit.
61
Which of the following are common early signs of a pituitary adenoma? Persistent headaches Hemianopia Hypertension Papilledema
Persistent headaches Hemianopia
62
63
Which of the following does NOT apply to inappropriate ADH syndrome? The cause is excess ADH secretion. Severe hyponatremia results. Excessive sodium is retained. Fluid retention increases
Excessive sodium is retained
64
What is/are the effect(s) of thyrotoxic crisis Hyperthermia and heart failure Hypotension and hypoglycemia Toxic goiter and hypometabolism Decreased stress response
Hyperthermia and heart failure
65
Which of the following conditions may precipitate or exacerbate hyperglycemia? Hypothyroidism Cushings disease Addisons disease Growth hormone deficit
Cushings disease
66
Which of the following conditions may cause immunosuppression? Graves disease Acromegaly Cushings disease Diabetes insipidus
Cushings disease
67
Hyperosmolar hyperglycemic nonketotic coma (HHNC) more frequently develops in patients with: type 1 diabetes. type 2 diabetes. Graves disease. hyperparathyroidism.
type 2 diabetes.
68
Which of the following is recommended for immediate treatment of hypoglycemic shock If conscious, immediately give sweet fruit juice, honey, candy, or sugar. If unconscious, give nothing by mouth (require intravenous glucose 50%). Treat immediately with insulin. Give large quantity of clear fluids for shock.
If conscious, immediately give sweet fruit juice, honey, candy, or sugar. If unconscious, give nothing by mouth (require intravenous glucose 50%).
69
All these tissues use glucose without the aid of insulin EXCEPT: liver. digestive system. exercising skeletal muscle. brain
liver
70
Differences between type 1 and type 2 diabetes include which of the following? Type 1 diabetes weight gain is common, and type 2 weight loss often occurs. Type 1 diabetes leads to fewer complications than does type 2 diabetes Type 1 diabetes may be controlled by adjusting dietary intake and exercise, but type 2 diabetes requires insulin replacement. Type 1 diabetes occurs more frequently in children and adolescents, and type 2 diabetes occurs more often in adults.
Type 1 diabetes occurs more frequently in children and adolescents, and type 2 diabetes occurs more often in adults.
71
Complications of diabetes mellitus include: peripheral neuropathy. frequent infections. cataracts. A, B, and C
peripheral neuropathy. frequent infections. cataracts.
72
Which of the following often causes hyperparathyroidism? Amalignant tumor in the parathyroid glands End-stage renal failure Osteoporosis Radiation involving the thyroid gland and neck area
Radiation involving the thyroid gland and neck area
73
Dwarfism is caused by: excessive levels of somatotropin (GH). a deficit of somatotropin (GH). excessive levels of insulin. excessive levels of parathyroid hormone
a deficit of somatotropin (GH).
74
Which of the following results from a deficit of antidiuretic hormone (ADH)? Inappropriate ADH syndrome Gigantism Diabetes insipidus Myxedema
Diabetes insipidus
75
Goiters occur more frequently in persons living in the: Great Lakes or mountainous regions. southwest United States. temperate regions. areas bordering the oceans
Great Lakes or mountainous regions.
76
Which of the following is caused by Graves disease? Hypermetabolism Decreased size of thyroid gland Bradycardia and hypothermia Decreased blood levels of T3, T4, and TSH
Hypermetabolism
77
Goiters may be caused by: hypothyroid conditions only. either hypothyroid or hyperthyroid conditions. hyperthyroid conditions only. fungal infections such as candidiasis
either hypothyroid or hyperthyroid conditions.
78
Severe impairment of all aspects of growth and development, including difficulty feeding, mental retardation, and stunted skeletal growth, are associated with myxedema Cushings syndrome. diabetes insipidus. cretinism. Graves disease.
cretinism.
79
Abenign tumor of the adrenal medulla that secretes epinephrine and norepinephrine is called pheochromocytoma. Cushings syndrome. Graves disease. Addisons disease.
pheochromocytoma.
80
The anterior pituitary gland secretes all of the following hormones EXCEPT: prolactin (PRL). glucagon. adrenocorticotropic hormone (ACTH). growth hormone (GH).
glucagon.
81
Overproduction of thyroid hormones (T3, T4) leading to increased metabolism and sympathetic nervous system activity.
Hyperthyroidism
82
hyperthyroidism Routine screening at age -_____ (unless high risk)
50
83
Fatigue Weight Loss, Increased Appetite Anxiety, Insomnia, Irritability Heat Intolerance Increased Bowel Motility Vision Changes Palpitations Menstrual Changes
Hyperthyroidism
84
Muscle atrophy, tremors Warm, flushed, and moist skin Hyperpigmentation Fine silky thinning hair, Exophthalmos Hyperactive reflexes Tachycardia Enlarged Thyroid
Hyperthyroidism
85
Agitation, delirium, psychosis, seizures, Coma (late stage), Severe tachycardia, atrial fibrillation, Shock, Heart failure, Pulmonary Edema, High fever (> 102–106°F or > 39°C), Diaphoresis, Severe nausea, vomiting, diarrhea, abdominal pain, hepatomegaly and/or jaundice
Thyroid Storm
86
Infection Trauma Severe emotional or physical stress Abrupt withdrawal of antithyroid medications Uncontrolled Graves’ disease DKA (Diabetic Ketoacidosis) Iodine overload (contrast dye, amiodarone) can all be a cause for
Thyroid Storm
87
Hyperthyroidism is diagnosed by
low TSH, high T3 & T4 Confirmatory Thyroid Autoantibodies Radioactive Iodine Uptake (RAIU) Scan Thyroid Ultrasound Serum Thyroglobulin Erythrocyte Sedimentation Rate (ESR) Electrocardiogram (ECG)
88
mangement for hyperthyroidism
Beta-blockers (for tachycardia) **Antithyroid Drugs: ** Propylthiouracil (PTU) - thyroid storm or pregnancy Methimazole (MMI) Radioactive Iodine Surgery
89
Underproduction of thyroid hormones (T3, T4) leading to decreased metabolism and systemic effect
hypothyroidism
90
Primary (Thyroid Dysfunction): Hashimoto’s thyroiditis (autoimmune destruction) Iodine deficiency Post-surgical or post-radioiodine ablation Congenital hypothyroidism Medications (e.g., lithium, amiodarone)
hypothyroidism
91
Fatigue, weakness Cold intolerance Weight gain despite normal diet Depression, mood changes Constipation Dry skin, brittle nails, hair thinning Memory impairment, brain fog Hoarseness Menstrual irregularities, infertility Joint and muscle pain
hypothyroidism
92
Bradycardia Hypotension Cool, dry, pale skin Periorbital and facial edema Delayed reflexes Non-pitting edema (myxedema) Goiter (enlarged thyroid in Hashimoto’s) Coarse, brittle hair and thinning of lateral eyebrows (Queen Anne’s sign
hypothyroidism
93
Contributing Factors: Infection Surgery Trauma Cold exposure Sedative or opioid use
Myxedema Crisis (Severe Hypothyroidism Emergency)
94
Symptoms: Severe hypothermia Bradycardia, hypotension Hypoventilation Altered mental status, coma Hypoglycemia, hyponatremia
Myxedema Crisis (Severe Hypothyroidism Emergency)
95
First-line treatment: Levothyroxine (synthetic T4) Dosing: Start low in elderly or cardiac patients Adjust based on TSH levels (check every 6-8 weeks initially) Lifestyle Modifications: Adequate iodine intake Regular follow-up for medication adherence Monitor for overtreatment (signs of hyperthyroidism)
Hypothyroidism
96
Thyroid-Stimulating Hormone (TSH): Elevated Free T4 (FT4): Low in all types
Hypothyroidism
97
S&S is painless nodule/lump in neck (fixed, nontender, firm, irregular), difficulty breathing, (hoarseness & hemoptysis indicate malignancy
thyroid cancer
98
thyroid cancer diagnostic tests
High-resolution ultrasonography to identify nodules present Fine-needle aspiration biopsy to determine benign or cancerous Elevated Serum Calcitonin is strong marker for tumor CT or MRI best when Tumor is Large, recurrent or invades other area
99
Inadequate secretion of PTH, leading to hypocalcemia and neuromuscular excitability. Rare; mostly due to post-surgical causes.
Hypoparathyroidism
100
Causes of ______ Surgical removal of parathyroid glands (most common) Autoimmune destruction Congenital disorders (DiGeorge syndrome) Radiation-induced damage Severe magnesium deficiency (needed for PTH secretion)
Hypoparathyroidism:
101
Subjective Symptoms Muscle cramps, tingling, numbness (especially in fingers and lips) Anxiety, depression, irritability Dry skin, brittle nails, hair loss Difficulty swallowing or speaking (laryngospasm) Seizures (in severe cases)
Hypoparathyroidism:
102
Objective Signs Trousseau’s sign (carpopedal spasm when inflating BP cuff) Chvostek’s sign (facial twitching when tapping on facial nerve) Hyperactive deep tendon reflexes Laryngospasm or bronchospasm Prolonged QT interval on ECG (risk for arrhythmias)
Hypoparathyroidism:
103
Diagnostic Testing Low serum calcium (<8.5 mg/dL) Low PTH levels High serum phosphate Normal or low magnesium EKG: Prolonged QT interval (risk of arrhythmias)
Hypoparathyroidism:
104
Emergency Treatment (Acute Hypocalcemia Crisis): IV calcium gluconate if tetany, laryngospasm, or seizures occur Chronic Management: Oral calcium and vitamin D (Calcitriol - active vit. D) Magnesium supplementation if needed Lifelong monitoring of calcium, phosphate, and PTH levels (CMP, PTH assay)
Hypoparathyroidism:
105
Overproduction of parathyroid hormone (PTH) leading to hypercalcemia and increased bone resorption. More common in women; incidence increases with age. Routine Screening: Recommended in patients with unexplained hypercalcemia.
Hyperparathyroidism
106
Causes Primary: Parathyroid adenoma (85%), hyperplasia, or carcinoma. Secondary: Chronic kidney disease (CKD), vitamin D deficiency. Tertiary: Long-standing secondary
Hyperparathyroidism
107
Subjective Symptoms Fatigue, weakness Polyuria, polydipsia (excessive urination and thirst) Depression, confusion, or memory impairment Constipation, abdominal pain, nausea Bone pain, fractures Kidney stones
Hyperparathyroidism
108
Objective Signs Hypertension Dehydration (due to excessive calcium diuresis) Osteopenia or osteoporosis Nephrolithiasis (kidney stones) Muscle weakness
Hyperparathyroidism
109
Diagnostic Testing Elevated serum calcium (>10.5 mg/dL) Elevated PTH levels Low serum phosphate 24-hour urine calcium to rule out familial hypocalciuric hypercalcemia Bone density scan (DEXA) for osteoporosis risk Sestamibi scan/Ultrasound to locate a parathyroid adenoma
Hyperparathyroidism
110
Surgical Treatment: Parathyroidectomy Medical Management Hydration Biphosphonates Vitamin D & Phosphate Binders
Hyperparathyroidism
111
Specifically pituitary adrenocorticotropic hormone (ACTH) excess Due to cortical hypertrophy, tumor, or prolonged administration of glucocorticoid hormones, androgen excess
Cushing’s syndrome
112
S&S: slow onset, central obesity, moon face, buffalo hump, thinning & easily bruising skin, hirsutism, acne, striae, fungal infections, muscle weakness, osteoporosis, hormone changes
Cushing’s syndrome
113
diagnostic tests Plasma blood levels of cortisol (Norms Am=5-23 & afternoon=3-13) are elevated, CBC, Glucose, CMP 24-hour urinary free cortisol test is best for initial test Consider low-dose dexamethasone suppression test
Cushing’s syndrome
114
Destruction of insulin-producing pancreatic islet cells Associated with autoimmune responses Little to no autonomous insulin Production
DM1
115
Defective insulin secretion Decreased insulin sensitivity Peripheral insulin resistance
DM2
116
Prediabetes Impaired fasting glucose (IFP): Fasting plasma glucose ______-______ mg/dL Impaired glucose tolerance (IGT): Glucose levels ____--_____/dL 2h after 75 g oral glucose tolerance test HbA1c: ___-___%
Impaired fasting glucose (IFP): Fasting plasma glucose 100 – 125 mg/dL Impaired glucose tolerance (IGT): Glucose levels 120-199 mg/dL 2h after 75 g oral glucose tolerance test HbA1c: 5/7 – 6.4%
117
# clinical presentation Polydipsia, polyuria, polyphagia Anorexia Weight loss Nocturnal enuresis Vision changes, weakness, fatigue
dm 1
118
# diagnostic testing for DM1 Initial testing: Symptomatic of hyperglycemia + a random plasma glucose level of ____ mg/dL or higher Fasting plasma glucose level >___mg/dL 2-hour plasma glucose of ____ mg/dL or higher during an oral glucose tolerance test (OGTT) Hemoglobin A1c C-peptide level, acute insulin response test, DM related auto antibodies Lipid profile, urinalysis
Initial testing: Symptomatic of hyperglycemia + a random plasma glucose level of 200 mg/dL or higher Fasting plasma glucose level >126 mg/dL 2-hour plasma glucose of 200 mg/dL or higher during an oral glucose tolerance test (OGTT) Hemoglobin A1c C-peptide level, acute insulin response test, DM related auto antibodies Lipid profile, urinalysis
119
# complications of Retinopathy, nephropathy, neuropathy Coronary artery disease Macrovascular Disease: PVD, CAD,CVD Diabetic Ketoacidosis (DKA)
DM1
120
# risk factors Family History Poor diet Lack of exercise Obesity Age over 45 years old Impaired fasting glucose Large for gestational age baby African American, Hispanic American, Native American, Asian American, Pacific Islander
dm2
121
# Nonspecific symptoms Fatigue Malaise Anorexia Amenorrhea Erectile dysfunction Headache Blurred vision Muscle cramps Dehydration
dm2
122
Skin Manifestations Recurrent cellulitis or fungal infections Poor or delayed wound healing Generalized pruritus Acanthosis nigricans
dm2
123
HA1c confirmed for DM
6.5
124