Exam 3 Flashcards

(90 cards)

1
Q

osmosis

A

movement of WATER down a concentration gradient
-from low solute to high solute across semi permeable membrane

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2
Q

diffusion

A

movement of molecules from high concentration to low concentration

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3
Q

shifting of water

A

water follows electrolytes

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4
Q

colloids

A

substances that increase colloid osmotic pressure (oncotic pressure)
-MOVE FLUID FROM INTERSTITIAL COMPARTMENT TO PLASMA (BLOOD) COMPARTMENT
3 primary colloids: albumin, globulin, fibrinogen

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5
Q

hydrostatic pressure

A

force of fluid in compartment pushing AGAINST A CELL MEMBRANE, generated by BP, force that pushes water OUT of vascular system into interstitial space

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6
Q

oncotic pressure (colloid osmotic)

A

caused by plasma colloids (large molecules) in solution, plasma has LOTS of colloids, interstitial space has little, plasma proteins attract water, pulling fluid from tissue space INTO vascular space

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7
Q

electrolytes influence

A

fluid balance, acid base balance, nerve impulses, muscle contraction, heart rhythm, etc

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8
Q

what are electrolytes

A

substances that are electrically charged when in solution (K+, Mg+, Na+, Ca+, P-, Cl-, HCO3-)

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9
Q

concentrations of electrolytes are dependent on

A

electrolyte intake, absorption, distribution, and excretion

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10
Q

hyponatremia

A

low sodium

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11
Q

hypernatremia

A

high sodium

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12
Q

sodium

A

water follows sodium, governs osmolality, influences water distribution, aids in acid-base balance, activates muscle and nerve cells, ion movement important in action potentials

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13
Q

hyponatremia causes

A

GI losses, renal losses, skin losses, fasting diets, polydipsia, excess hypotonic fluid
S/S: confusion/altered LOC, anorexia, muscle weakness, can lead to seizures/coma

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14
Q

dilutional hyponatremia

A

hypervolemic, increased BP, weight gain, bounding pulse

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15
Q

depletional hyponatremia

A

hypovolemic, lower BP, tachy pulse, dry skin, weight loss

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16
Q

treatment of hyponatremia

A

SLOW sodium replacement, PO/IV, IV NS, fluid restriction, treat underlying problem

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17
Q

hypernatremia causes

A

IV fluids, tube feeds, near drowning in salt water-> excess sodium intake, not enough water intake or too much water loss-> cognitively impaired, diarrhea, high fever, heat stroke, profound diuresis
-S/S: altered LOC/confusion, seizure, coma, extreme thirst (hyperosmolality), dry sticky mucous membranes, muscle cramps

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18
Q

treatment of hypernatremia

A

if water loss is cause-> add water
if sodium excess is cause-> remove sodium
GRADUALLY ACHIEVE NORMAL LEVEL

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19
Q

hypokalemia

A

low potassium

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20
Q

hyperkalemia

A

high potassium

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21
Q

potassium

A

intracellular cation, helps regulate cell excitability and electrical status, helps control intracellular osmolality, diet is main source, kidneys main source of K loss-> pee out K

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22
Q

causes of hypokalemia

A

renal or GI losses, DIURESIS, acid base disorders (K in extracellular space goes into intracellular space)
-S/S: CARDIAC RHYTHM DISTURBANCES-LETHAL, muscle weakness, leg cramps, decreased bowel motility: constipation, nausea, ileus

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23
Q

causes of hyperkalemia

A

decreased K OUTPUT (renal failure, not peeing), burns, crush injuries, sepsis, anything with massive cell injury, drugs, K sparing diuretics, ACE, ARBs, NSAIDS
-S/S: cardiac rhythm disturbances, muscle weakness, cramps, abdominal cramping, diarrhea, vomiting

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24
Q

hyperkalemia treatment

A

diuretics

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25
magnesium
helps stabilize CARDIAC muscle cells, blocks/controls movement of K out of cardiac cells, helps stabilize smooth muscle
26
hypomagnesemia causes
diuresis, GI or renal losses, limited intake (fasting or starvation), alcohol use, pancreatitis, hyperglycemia -S/S: hyperactive reflexes, confusion, cramps, tremors, seizures
27
hypomagnesemia treatment
replacement oral or IV, treat cause
28
nystagmus occurs in what condition
hypomagnesemia
29
hypermagnesemia causes
increased intake accompanied by renal failure -S/S: lethargy, floppiness, muscle weakness, decreased reflexes, flushed/warm skin, decrease pulse/BP treatment: stop replacement, if chronic disease intake-> dialysis
30
calcium
hormones released by the THYROID AND PARATHYROID GLANDS are controllers of the amount of calcium that is released from and absorbed into the bone, 99% of calcium in bone
31
calcium facts
enzyme reactions, effects membrane potentials and nerve excitability, helps in release of hormones/neurotransmitters/chemical mediators, influences cardiac contractility and automaticity, necessary for blood clotting
32
hypocalcemia
unable to mobilize from bone, increased renal loss, increased binding, decreased intake or absorption, acute pancreatitis, thyroid or parathyroid surgery, increased neuromuscular excitability, cardiac insufficiency -positive chvostek's sign, positive trousseau's sign
33
hypocalcemia treatment
IV calcium or oral (tums)
34
hypercalcemia causes
hyperparathyroidism, cancers -S/S: calcium acts like a sedative, fatigue, lethargy, confusion, weakness, leading to seizures, coma, kidney stone
35
hypercalcemia treatment
adequate hydration, increased urine output, diuretics and NaCl, dialysis in renal failure
36
phosphorus
85% found in bone and 14% in intracellular, higher levels found in infants and children, organic and inorganic forms, role in bone formation, essential for ATP formation and enzymes needed for glucose/protein/and fat metabolism. acid-base buffer, normal function of WBCs and platelets CALCIUM AND PHOSPHATE WORK TOGETHER, LOW SERUM CALCIUM= HIGH PHOSPHATE
37
causes of hypophosphatemia
decreased absorption, antacids overdose, severe diarrhea, increased kidney elimination, malnutrition -clinical manifestations: tremor, paresthesia, confusion to coma, seizure, muscle weakness, joint stiffness, bone pain, etc
38
causes of hyperphosphatemia
kidney failure, laxatives/enemas with phosphorus, shift from intra to extra cellular compartment, hypoparathyroidism -clinical manifestations: asymptomatic, typically symptoms of hypocalcemia: muscle spasms paresthesia, tetany
39
tinea pedis
athlete's foot, dry scaling pruritic lesions, web between toes risk factors: coming into contact with skin or environmental fungus prevention: use of shower shoes, clean tub, treat with topical antifungals
40
tinea capitis
hair, can affect scalp, eyebrows, or eyelashes, lesions and hair loss, baldness treatment: PO systemic antifungals bid for 4-6 weeks, topicals are NOT effective
41
tinea versicolor
skin on upper chest, back, or arms, caused by type of yeast, looks like acidic bleach causing discoloration, risk factors include hot climate, sweaty, oily skin, weakened immune system, NOT contagious treatment: topical antifungals
42
candidiasis
thrush/yeast infections, may appear as white lesions in mouth, beefy red lesions in skin folds, treat with topical antifungal agents risk factors: immunosuppression and antibiotic use
43
systemic fungal infections
require aggressive treatment with PO/IV antifungals, affect INTERNAL organs
44
pigmented lesions
melasma and vitiligo
45
melasma
characterized by dark macules on the face, more common in women, treat with avoiding sun, bleaching creams, tretinoin/retin-A
46
vitiligo
acquired condition characterized by abnormalities in the production of melanin, pigment disappears from a patch of skin, occurs suddenly before or around age 21, affected areas spread, no treatments, unknown cause
47
viral skin infection
herpes zoster
48
herpes zoster: shingles
varicella zoster virus lies dormant on a dermatome segment after infections with chickenpox, virus becomes reactivated by immunosuppression, stress, or illness -prodrome: burning/tingling along dermatome and then rash develops with vesicles that dry and crust over -characteristics: vesicles on red base that follow along dermatomal distribution-asymmetric (does not cross midline), painful, clears in 2-3 weeks, people 50+/anyone who has had chickenpox, most contagious when vesicles are weeping, treat with antivirals, complication of persistent pain where rash was
49
bacterial skin infections
impetigo, abscess, furuncle, cellulitis, MRSA (staph)
50
impetigo
organisms carried in the nose, acute and contagious, appears as vesicles, pustules, honey colored crust on red base, treat with topical antibacterial
51
abscess
skin inflamed and red with collection of pus, area often raised with palpable borders, tender, may drain purulent discharge or feel fluctuant, treat with incision and drainage and antibiotics
52
furuncle and carbuncle
furcuncle is bacterial infection of HAIR FOLLICLE, carbuncle is painful, deep swelling of skin caused by bacteria, treat with incision and drainage and antibiotics
53
cellulitis
caused by bacterial infection of skin and surrounding tissues, not contagious, appears red, painful, swollen, warm to touch, blisters, treat with PO systemic antibiotics or IV
54
MRSA
caused by type of staph bacteria resistant to many antibiotics, hospital or community acquired, warm to touch, purulent drainage, fever, abscess can develop quickly
55
skin cancers
basal cell, squamous cell, melanoma
56
precancerous lesions
actinic keratosis: benign lesions, due to damage by sun's UV rays, common in light skins persons solar lentigos: benign lesions, also known as liver/age spots
57
basal cell carcinoma
most common, least often malignant, lighter skin tone, increased risk with sun exposure, most curable -nodular form that begins as small flesh colored or pink dome shaped bump, translucent, shiny, pearly nodule, shiny border, non metastasizing
58
squamous cell carcinoma
2nd most frequent, increased risk with sun exposure, curable with early treatment, can metastasize to lymph nodes or internal organs, red and scaling, keratotic, slightly elevated lesion with irregular border
59
melanoma
malignant cells grow on skin radially spreading in epidermis and vertically spreading deep into dermis, can form in eyes and under nails -risk factors: family history, blonde/red hair, freckling on upper back, hx of 2+ blistering sunburns before age 20, hx of 3+ years of outdoor job as teenager -ABCDE, most deadly
60
misc skin disorders
eczema and psoriasis
61
eczema
conditions that cause skin to become inflamed or irritated, not contagious
62
psoriasis
long term chronic condition, not contagious, young adulthood, over-active immune system, link between psoriasis/obesity/CVD -skin cells grow too quickly causing skin to be thick, white, silvery, or have red patches of skin-> plaques
63
erythrocytes
red blood cells, most abundant cells of blood, primarily responsible for TISSUE OXYGENATION, Hgb carries these gasses
64
leukocytes
white blood cells never let monkeys eat bananas Neutrophils lymphocytes monocytes eosinophils basophils
65
granulocytes
neutrophils eosinophils basophils
66
agranulocytes
lymphocytes monocytes
67
neutrophils
first to arrive at site of inflammation, bands and segs, increase with acute bacterial infections and trauma, shift to the left (increase of bands)
68
lymphocytes
primary cells of immune response, increase with chronic bacterial infection and acute viral infection -B & T cells
69
monocytes
phagocytosis, increase with bacterial infections and cancers
70
eosinophils
increase with allergic reactions or parasitic infections, worms/wheezes/weird diseases
71
basophils
increase with allergic reactions (hypersensitivities, inflammatory reactions)
72
hemoglobin
measures amount of hemoglobin in your blood (oxygen carrying capacity) low: bleeding, folate/B12 deficiencies, cancers, kidney and liver disease high: polycythemia, COPD, live in high altitude, heavy smoking
73
hematocrit
percentage of blood that is made up of packed red blood cells, interpreted in percentages low: anemia, bleeding, bleeding disorders, FLUID IMBALANCES high: polycythemia, COPD, dehydration, shock, congenital heart disease
74
red cell count
of erythrocytes in blood
75
mean corpuscle volume (MCV)
size of erythrocytes
76
mean corpuscle hemoglobin (MCH)
amount of hemoglobin in erythrocyte by weight
77
increased WBC count
leukocytosis
78
decreased WBC count
leukopenia decreased neutrophils=neutropenia
79
mononucleosis "mono"
infection of B lymphocytes, acute phase 2-3 weeks, some degree of debility/lethargy, treat symptomatic and supportive, symptoms lymphadenopathy, hepatitis, splenomegaly, etc
80
myelodysplastic syndrome
group of related hematologic disorders characterized by change in the quality/quantity of bone marrow elements, "bone marrow failure disorder" CM: cytopenias, anemia, infection/bleeding treatment: supportive, G-CSF, chemo, bone marrow transplant
81
leukemias
malignant neoplasms of cells originally derived from a single hematopoietic cell line cells are: immature and unregulated, proliferate in bone marrow, circulate in blood, infiltrate spleen and lymph nodes, disease of children and adults
82
leukemia classifications
classified according to their predominant cell type (lymphocytic or myelocytic) and whether it is acute or chronic (ALL, CLL, AML, CML)
83
leukemia pathogenesis
cells: immature type of WBC, capable of increased rate of proliferation/have prolonged life span, cannot perform function of mature leukocytes (are ineffective as phagocytes), interfere with maturation of normal bone marrow cells
84
acute leukemia
sudden, stormy onset, S/S related to decreased mature WBC and RBC and platelets diagnosis based on blood/bone marrow tissue, presence of immature WBC
85
chronic leukemia
more insidious onset, can be discovered in routine blood count
86
leukemia treatment
goal is to attain remission, cytotoxic chemotherapy, stem cell transplant, risk of infection/rejection/relapse
87
malignant lymphomas
neoplasms of cells derived from lymphoid tissue- hodgkin and non-hodgkin disease
88
hodgkin disease
-characterized by painless, progressive, rubbery enlargement of a single node or group of nodes usually in neck -REED-STENBERG CELL-distinctive tumor cell found with lymph biopsy -diagnosis: peripheral blood analysis, lymph node biopsy, bone marrow exam, radiographic evaluation -treatment: chemo, radiation, stem cell transplant
89
non-hodgkin disease
-also neoplastic disorder of lymphoid tissue, SPREADS EARLY, also painless, superficial lymphadenopathy, majority of pts have widely spread disease at time of dx -CM: painless lymph node enlargement also -dx: similar to hodgkin, increased extranodal sites -treatment: chemo, radiation, refractory cases-stem cell transplant, mab meds
90
multiple myeloma
-plasma cell cancer (B cells) -atypical proliferation of one of immunoglobulins, unable to maintain humoral immunity, characterized by bone fractures/pain -CM: slow/insidious, skeletal pain, hypercalcemia -diagnostics: lab, radiographic, bone marrow exam -treatments: watching, corticosteroids, chemo, biologic therapy, stem cell transplant, biphosphonates, adequate hydration