Exam 3 Flashcards
(141 cards)
monosodium urate crystals
hyperuricemia (purine metabolism = uric acid)
95% underexcreters (mostly decrease renal function)
stage I - asymptomatic, no treatment needed
stage II - acute, severe attack of 1 joint
stage III - after 10+ years of acute attacks, chronic swelling and tophi
rapid onset pain, redness, warmth
PODAGRA - MTP joint of great toe
often recurrent
Gout
Gout diagnostics and treatment
radiography = joint erosion arthrocentesis = (-) BIREFRINGENT
Treatment: analgesia, NSAIDs (indomethacin or Naproxen)
Colchicine (diarrhea side effect)
glucocorticoids if can’t take NSAID or colchicine - sugar can rise in DM pts
*Urate-Lowering Therapy - goal to maintain serum uric acid of 6.0 or less
Probenecid - uricosuric agent
–> underexcreters only and avoid in pt with ASA (aspirin) use or nephrolithiasis (kidney stones)
Allopurinol (Zyloprim) and Febuxostat (Uloric) - xanthine oxidase inhibitors
Agent of Choice - Allopurinol - good for both over and underexcreters
Prophylaxis with colchicine or NSAID first, then initiate urate-lowering therapy
–> may precipitate an acute attack
calcium pyrophosphate dihydrate (CPP) crystals
comorbidities
acute, typically mono-articular - 50% knees
may mimic RA, OA or septic arthritis
self-limited
Pseudogout (chondrocalcinosis or CPPD deposition disease)
Pseudogout diagnostics and treatment
synovial fluid aspiration - (+) BIREFRINGENT
Treatment: NSAIDs or cholchicine glucocorticoids (oral or systemic) if above doesn't work remove crystals via joint aspiration ice joint immobilization
considered chronic if 3+ attacks in a year
autoantibodies to nuclear antigens (inflammatory autoimmune disorder)
multi system disease
more common in blacks and females
fever, fatigue, weight change malar rash photosensitivity symmetric nonerosive arthritis Raynaud's phenomenon (white - blue - red episodic vasospastic disease) serositis (cardiopulmonary inflammation)
Systemic Lupus Erythematous (SLE)
Systemic Lupus Erythematous (SLE) diagnostics and treatment
ANA –> anti-dsDNA and anti-Sm subtypes
C3 and C4 - complement system
CBC, ESR (erythrocyte sedimentation rate/sed rate)
imaging if needed
Treatment: sun protection, diet, exercise, etc.
NSAIDs and rest for mild sxs
cytotoxic/immunosuppressive agents (ie. methotrexate) for severe sxs
systemic corticosteroids
antimalarials - hydroxychloroquine (Plaquenil) with ophthalmology f/u
drug-induced SLE (HIP drugs among others - hydralazine, isoniazid, procainamide)
–> (+) antihistone antibody
chronic, systemic autoimmune disorder
diminished exocrine gland function (salivary & lacrimal)
more common in females
common association with SLE, RA and systemic sclerosis
SICCA complex - dry eyes, dry mouth --> keratoconjunctivitis, xerostomia arthritis/arthralgia parotid gland enlargement fatigue Raynaud's
Sjogren Syndrome (SS)
Sjogren Syndrome (SS) diagnostics and treatment
ANA –> anti-Ro.SSA and anti-La/SSB subtypes
Schemer’s test - tear production
salivary gland biopsy
Treatment: regular f/u with dentist and ophthalmologist
dry eyes –> artificial tears, cyclosporine drops
xerostomia - biotene OTC (saliva substitute)
steroids
rare, chronic autoimmune disorder diffuse FIBROSIS of skin and internal organs skin appears taut and shiny 2 forms: limited (80%) diffuse (20%) more common in females
arthralgia/arthritis
pericarditis
renal and pulmonary HTN
limited: CREST syndrome calcinosis cutis (calcification of subQ tissues) Raynaud's esophageal dysmotility sclerodactyly (puffy hands) telangiectasia
diffuse (worse prognosis):
rapid development of symmetric skin thickening on trunk and proximal extremities
more likely to have significant internal organ damage
Systemic Sclerosis (Scleroderma)
Systemic Sclerosis (Scleroderma) diagnostics and treatment
ANA –> anti-SCL-70
proteinuria (renal involvement)
Treatment: symptomatic and supportive
Raynaud’s - Nifedipine (Ca2+ channel blocker)
Esophageal - H2 blockers, H+ pump inhibitors, small more frequent meals
inflammatory arthritis triggered by antecedent GI/GU infection
HLA-B27 + (85%)
“can’t see, can’t pee, can’t climb a tree”
more common in men (post-GU infection)
acute, asymmetric oligoarthritis - often lower extremities
1-4 weeks post-GI/GU infection
diarrhea (GI) or urethritis (GI - “can’t pee”)
conjunctivitis (“can’t see”)
keratoderma blennorrhagicum on palms and soles
Reactive Arthritis (“Reiter’s Syndrome”)
Reactive Arthritis (“Reiter’s Syndrome”) treatment
NSAIDs - indomethacin
intra-articular/systemic glucocorticoids
methotrexate (MTX) or anti-TNF (cytotoxic/immunosuppressive) if above doesn’t work
sxs resolve 6-12 months
chronic, systemic, inflammatory autoimmune disorder
thickening of synovial membrane = inflammation (synovitis)
–> can lead to carpal tunnel over time
destruction of cartilage and bone
joint deformity and loss of fctn if not treated
gradual onset
symmetric polyarthritis
*morning stiffness for at least 1 hour
distal sites affected early - MCP and PIP joints
phys exam: ulnar deviation of MCP joints Boutonniere deformity (PIP) Swan neck deformity (DIP) - more severe disease tenderness/swelling *rheumatoid nodules = unfavorable sign (elbows)
Rheumatoid Arthritis (RA)
Rheumatoid Arthritis (RA) diagnostics and treatment
radiography - preferred initial --> soft tissue swelling around joint --> periarticular osteopenia (thinning bones around joint) --> narrowing joint space --> subluxation/dislocation --> bone erosion and joint obliteration MRI and U/S to check for synovitis joint aspiration if unsure
Lab: CBC/ESR
rheumatoid factor (RF) –> (+) early in course = more severe
anti-CCP antibodies (newer and more specific)
ANA (non-specific)
Treatment: control synovitis, prevent joint injury, preserve ADLs
NSAIDs + glucocorticoids
DMARDs (disease modifying anti-rheumatic drugs)
–> slows/halts disease progression
–> refer to Rheumatology
ex. methotrexate, sulfasalazine (synthetic)
ex. TNF inhibitors Enbrel, Remicaid, Humira (biologic) - risky
*CVD most common cause of death
degenerative joint/disk disease
risks: age, female, obesity, genetic, general wear/tear
pain exacerbated by activity and relieved by rest
morning stiffness typically resolves in less than 30 min
typically hands, knee, hip, pine
crepitus bony enlargement decreased ROM and malalignment tenderness Bouchard's nodes (PIP) Heberden's nodes (DIP) 1st carpometacarpal joint (CMC) osteophytes effusions pain around hip/groin referred to knee cervical and lumbar spondylosis
Osteoarthritis (OA)
Osteoarthritis (OA) diagnostics and treatment
radiological: joint space narrowing
osteophytes
subchondral sclerosis and cysts
(-) RF and anti-CCP
no joint obliteration like RA
Treatment: pain control
minimize disability and pt education
NSAIDs (ie. diclofenac)
narcotics - sparingly if at all
intra-articular glucocorticoids
–> no more than 2-3 times per year - atrophy to cartilage
surgical = joint replacement or resurfacing
chronic inflammatory rheumatic condition
*association with giant cell (temporal) arteritis
gradual onset symmetric stiffness at least 30min
shoulder pain > hip and neck (proximal regions)
synovitis and bursitis
edema
decreased ROM
“gel” phenomenon = stiffness after periods of rest
Polymyalgia Rheumatica (PMR)
Polymyalgia Rheumatica (PMR) diagnostics and treatment
elevated ESR (>40)
(-) ANA, RF, anti-CCP
imaging - x-ray, MRI, U/S
*general rule of thumb:
male = age/2 = ESR
female = (age + 10)/2 = ESR
Treatment: RAPID RESOLUTION with low dose glucocorticoids (ie. prednisone)
MTX or TNF inhibitors for select pts
PT
NSAIDs
soft tissue pain disorder - muscles, tendons, ligaments
widespread, chronic
women 20-55yo = common complaint
no tissue inflammation
aching stiffness fatigue paresthesia hard time explaining what hurts headaches insomnia superficial pain in 11/18 tender points
Fibromyalgia
Fibromyalgia treatment
cyclobenzaprine - muscle relaxer
antidepressant - amitriptyline, cymbalta (SNRIs)
anticonvulsants - Lyrica, Neurontin (gabapentin)
psych referral
*avoid narcotics - addiction
non-displaced
fragments in anatomic alignment
displaced
fragments no longer in usual alignment
angulated
fragments maligned and angular
bayonetted
distal fragment longitudinally overlaps proximal fragment