Exam 3 Flashcards
(142 cards)
carcinogenesis
malignant transformation involving 3 step process of initiation, promotion, and progression
Initiation
carcinogen damages DNA by changing a specific gene
Promotion
process by which carcinogens are subsequently introduced
Progression
process by which tumors go from bad to worse
- neovascularization
- invasion
- metastasis
Proto-oncogenes
Turn on cell growth
Anti-oncogenes
Turn off cell growth
Hypertrophy
cell growth that causes tissue to increase in size by enlarging each cell
Hyperplasia
growth that causes tissue to increase in size by increasing the number of cells
Metaplasia
conversion from the normal pattern of differentiation if one type of cell into another type of cell not normal for that tissue
Dysplasia
an alteration in the shape, size, appearance, and distribution of cell
Anaplasia
disorganized, irregular cells that have no structure and have loss of differentiation; the result is almost always malignant
Neoplasia
new or continued cell growth not needed for normal development or replacement of dead and damaged tissues.
ANC levels that increase the risk for infection
1,500 risk for infection increases; 500 severe risk for infection
Nadir
lowest level of ANC after chemotherapy
Collaborative mgmt of sepsis and DIC
- prevention is best measure
- IV antibiotic therapy
- Anticoagulants
- cryoprecipitated clotting factors
Collaborative mgmt of SIADH
- fluid restriction
- increased sodium intake
- demeclocycline
- treating the underlying cancer
Signs and symptoms of superior vena cava syndrome
edema of face, Stoke’s sign, edema of arms and hands, dyspnea, erythema, cough, hoarseness
Antimetabolites
“imposter” metabolites used to fool cancer cells into using them for cellular reactions will impair division
Antitumor antibiotics
damage cell DNA and interrupt DNA and RNA synthesis
Alkylating agents
inhibit DNA and RNA synthesis, and therefore cell division, by tightly binding DNA strands together
Antimitotic agents
Interfere with the formation of microtubules necessary for mitosis, comes from vinca plant
Factors delaying wound healing
- Poor nutrition
- Tissue perfusion and oxygenation
- excessive wound drainage
- Diseases
- Age
- Medications
- Infection
Braden scores
- 12 or less is high risk for development of ulcer
- 18 at risk for ulcer
PUSH score
0 is healed; 17 not healed