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Cardio I > Exam 3- Hypertension Therapeutics - Patel > Flashcards

Exam 3- Hypertension Therapeutics - Patel Flashcards

1
Q

Thiazide/ Thiazide Like Diuretics MOA

A

inhibits NaCl transporter on DCT

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2
Q

Name the Thiazide/ Thiazide Like Diuretic.

A

HCTZ (Microzide)

12.5 - 25 mg QD

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3
Q

Name the AE’s associated with Thiazide/ Thiazide Like Diuretic and the associated monitoring parameters.

A

Decrease
Na
K, Mg

Increase
Uric Acid
glucose 
Ca
TG's

Monitoring
BP, Na, K, glucose, TGs, Uric acid, SCr

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4
Q

What causes increased gout in patients that take Thiazide/ Thiazide Like Diuretics?

A

the increase in urea

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5
Q

Sexual dysfunction + photo sensitivity are associated w/ what type of drugs?

A

Thiazide/ Thiazide Like Diuretics

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6
Q

What happens if lithium is taken with HCTZ?

A

lithium clearance will decrease

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7
Q

What happens if you take HCTZ with a bile sequestrant?

A

HCTZ absorption will decrease

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8
Q

Name the clinical pearls associated with Thiazide/ Thiazide Like Diuretics. (3)

A
  • gout
  • sulfa allergy
  • 25 mg max effective dose
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9
Q

ACEI MOA

A

Block ACE enzyme which blocks Angio I to Angio II conversion

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10
Q

Name the ACEI drugs

A

Lisinopril (Prinivil/Zestril): 10-40mg QD

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11
Q

What is the MOA for ACEI

A

blocks ACE enzyme which blocks Angio I to II conversion

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12
Q

Name the ACEI (REBL)

A

Ramipril (Altace)
Enalapril (Vasotec)
Benazepril (Lotensin)
Lisinopril (Prinivil/Zestril) : 10-40 mg QD

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13
Q

What ACEI has the lowest half-life? How is it excreted How does this effect dosage and compliance?

A

Captopril
Renally
Dosed frequently
Decreased compliance

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14
Q

What ACEIs are only dosed once day?

A

Fosinopril
Lisinopril
Trandolapril

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15
Q

Name the 2 major AEs associated w/ ACEIs.

A

Dry Cough

Angioedema

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16
Q

What causes the dry cough and angioedema associated with ACEIs? Others?

A

increased levels of bradykinin

Hypotension, K+ increase, SCr transient increase

17
Q

What 3 monitoring parameters are associated w/ ACEIs

A

BP, K+, SCr

18
Q

Hyperkalemia occurs more frequently in what group(s) of patients who are on an ACE inhibitor?

A

CKD patients
Patients taking K+, NSAIDs, K+ sparing diuretics
Type II diabetes + CKD

19
Q

What prego category do ACEIs fall into?

A

Pregnancy D

20
Q

What is the MOA of ARBs?

A

competitive inhibition of Angio-1 receptors

21
Q

True/False

ACEIs + ARBs can be taking in conjunction.

A

False

- can not

22
Q

Name the ARBs drugs.

A

Losartan (Cozaar): 50-100 mg in 1-2 doses (daily)
Olmesartan (Benicar)
Valsartan (Diovan)

23
Q

True/False

The adverse event associated w/ ARBs are the same as?

A

ACEIs
- Prego- D
-

Cardio I (9 decks)

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