Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Pop > Exam #4 > Flashcards

Exam #4 Flashcards

(61 cards)

Start Studying
1
Q

Yohimbine (Yobine)

A

alpha 2 antagonist

Naturally occuring alkaloid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Carvedilol (Coreg)

A

Non-selective adrenoceptor antagonist

Lipid Soluble

Without ISA

alpha blocking and antioxidant properties

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Labetalol

A

Non-selective adrenoceptor antagonist

Water Soluble

With ISA

alpha blocking activity

used for hypertension in pregnancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

With ISA Beta Blocker Effects

A

Increase the HR at rest but decrease it during exercise

Less likely to effect lipid profile

Overall uncertain clinical significance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Metyrosine

A

Affect Noradrenergic Neurons

Helps control blood pressure and sweating

Blocks Catecholamine synthesis by inhibiting tyrosine hydroxylase, which would eventually lead to adrenaline production.

Side effects of sedation and drowsiness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Reserpine

A

Affects Noradrenergic Neurons

Blocks the transportation of norepinepherine into vessicles, making it accululate in the cytoplasma

Was used to treat hypertension - ineffective

Major side effect of depression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Guanethidine

A

Affects Noradrenergic Neurons

Neuron blocking drug

inhibits the release of norepinepherine from adrenergic nerve terminal

Displaces NE in the synaptic vesicles, causing long lasting depletion of NE similar to reserpine

Used to treat hypertension

Side effects of postural hypotension, diarrhea, nasal congestion, failure of ejaculation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Trimethaphan

A

Autonomic nicotinic ganglia blocker

non-depolarizing competitive antagonist

produces controlled hypotension during surgery

lowers blood pressure through decreasing heart rate and contractility. Also decreases sympathetic reflex

used in PTs with acute aortic dissection and pulmonary edema

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Botox

A

Inhibition of acetylcholine release

local anesthetic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Tubocurarine

A

Blockade of nicotinic cholinergic receptors at NMJ

Non-depolarizing competitive inhibitors

paralyses, but is not a anesthetic

rapid onset and not access to the brain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Succinylcholine

A

Prolonged agonist action at Nm receptors

depolarizing non-competitive agonist

Muscle relaxant during surgery and coma

hydrolyzed by plasma esterases

two phases - depolarization (muscle no longer responsive to Ach) and slow repolarization

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Bethanechol

A

Cholanergic agonist

Predominantly Muscarinic

GI and Urinary tract target

Treats bladder and GI hypotonia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Cevimeline

A

Cholanergic agonist

Targets M3

Treats Sjogrens syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Atropine

A

Muscarinic antagonist

Treats sinus bradycardia

Dries secretions for anesthetic premedication

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Tropicamide

A

Muscarinic antagonist

Dilate the pupils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Cyclopentolate

A

Muscarinic antagonist

Dilate the pupils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Benztropine

A

Muscarinic antagonist

Treatment for Parkinson’s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Ipratropium

A

Muscarinic antagonist

Bronchodilation, treatment for asthma and COPD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Tiotropium

A

Muscarinic antagonist

Bronchodilation, treatment for asthma and COPD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

dicycloverine

A

Muscarinic antagonist

Anti-spasmodic for those with IBS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Darifenacin

A

Muscarinic antagonist

Relive symptoms of overactive bladder

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Phentolamine

A

Non-selective alpha antagonist

Irreversible

High agonist concentrations can overcome the effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Phenoxybenzamine

A

Non-selective alpha antagonist

Irreversible

High agonist concentrations can overcome the effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Prazosin (Minipress)

A

alpha 1 antagonist

Short 1/2 life

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Doxazosin (Cardura)
Alpha 1 antagonist Longer 1/2 life
26
Atenolol (Tenormin)
B1 Selective adrenoceptor antagonist Water Soluble Without ISA
27
Metoprolol (Lopressor)
B1 Selective adrenoceptor antagonist Lipid Soluble Without ISA
28
Nadolol
Non-selective adrenoceptor antagonist Water Soluble Without ISA Longest Half life
29
Pindolol
Non-selective adrenoceptor antagonist Lipid Soluble With ISA
30
Nebivolol
B1 selective adrenoceptor antagonist Water Soluble With beta-3 agonist ISA Nitric oxide release
31
Esmolol
B1 selective adrenoceptor antagonist Water Soluble Without ISA Ultra Short acting
32
Non-selective Beta Blocker effects
Can cause bronchoconstriction in asthmatic patients which does not respond to B-2 agonist bronchodilators
33
B1 selective blockers Effects
LESS likely to cause severe bronchoconstriction
34
Lipid Soluble Beta Blocker Effects
More metabolized by the liver, have shorter 1/2 lives, can pass BBB (nightmares)
35
Water Soluble Beta Blocker Effects
More excreted by the kidney, have longer 1/2 lives, do not pass BBB
36
Neostigmine
inhibition of acetylcholine hydrolysis Increases Ach concentration at synaptic clefts
37
Sugammadex
Selective relaxant binding agent cyclo dextrin derivative that encapsulates and bind curare-like drugs
38
M2
Cardiac: heart and presyaptic on cholinergic neurons
39
M3
Granular/SM: exocrine glands and smooth muscle
40
M5
dopaminergic neurons in the brain
41
Pilocarpine
Cholanergic Agonist Eye target Treats glaucoma
42
Hyoscine (scopolamine)
Muscarinic antagonist Prevention of Motion sickness Dry secretions for Pre-surgury (Anethetic and endoscopy)
43
Benzhexol
Muscarinic antagonist Treatment for Parkinson's
44
Oxybutynin
Muscarinic antagonist Relive symptoms of overactive bladder
45
Tolerodine
Muscarinic antagonist Relive symptoms of overactive bladder
46
Tamsulosin (Flomax)
alpha 1A antagonist More selective towards bladder and cause less hypotension
47
Propranolol (Inderal)
Non-selective B adrenoceptor antagonist Lipid soluble Without ISA
48
M1
Neural: Brain areas involved in learning and memory
49
M4
CNS: presynaptic on cholinergic neurons
50
Pyridiostigmine
Acetylcholinesterase Inhibitor Increase Ach at Synaptic cleft
51
Pancuronium
Mimic of Tubocurarine long acting
52
Vecuronium
Mimic of Tubocurarine Intermediate acting
53
Rocuronium
Mimic of Tubocurarine Intermediate acting
54
Atracurium
Mimic of Tubocurarine Short acting
55
Methacholine
Muscarinic agonist Specificity for cardiac (M2)
56
Carbachol
Muscarinic agonist No specificity, similar to Ach
57
Distigmine
Cholinesterase inhibitor Specificity for Bladder and GI
58
Tacrine (Cognex)
Carbamate (cholinesterase inhibitor)
59
Donepazil (Aricept)
Carbamate (cholinesterase inhibitor) Treats Alzheimer
60
Galantamine (Razadyne)
Carbamate (cholinesterase inhibitor) Treats Alzheimer's
61
Rivastigmine (Exelon)
Carbamate (cholinesterase inhibitor) Treats Alzheimer's

Pop (1 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions