exam 4 Flashcards
HPG axis
hypothalamic-pituitary-gonadal axis
which hormones on the HPG axis are tropic
GnRH, LH, FSH
positive feedback disfavors
balance, equilibrium, homeostasis
examples of positive feedback loops
childbirth, menstrual cycle
most important control system of endocrine
brain
posterior pituitary tissue
nervous
anterior pituitary tissue
epithelial
is posterior or anterior pituitary part of the brain
posterior
where did the anterior pituitary come from
piece of epithelial from mouth during fusion during development
since anterior pituitary is not of nervous regions, neurons….
do not go into
no physical connection between anterior pituitary and
brain
neurons that release hormones synapse with
bloodstream
how does “A” show up in the feedback loops
neuronal hormone release
hypothalamus to pituitary
infundibulum
hypophysis
hypothalamus, pituitary
supraoptic nucleus
above optic chiasm
nucleus
cluster of cells
important nucleus
supraoptic, arcuate (AN)
GnRH released by
hypothalamus, AN
GnRH stimulates
FSH, LH
vesicles that contain GnRH synapse on
superior hypophyseal artery
half life of GnRH
3 mins
half life of FSH
22 mins
half life og LH
20 mins
half life of testosterone, estrogen, progesterone
45, 30, 66
why do hormones have different half life times
to ensure that the last hormone in the negative feedback loop gets the last word and the process is complete
how many follicles mature
1
all reproductive cells in women are made
at birth
how many eggs ovulated each month
1
where are ovarian hormones produced
corpus luteum
corpus luteum
“destroyed” egg
ectopic pregnancy
implantation/development happens anywhere but the uterus
signs and symptoms of ectopic pregnancy
lower abdominal pain on one side
uterine and ovarian cycles are synchronized but
independent
thickness of ___ changes throughout the menstrual cycle
endometrium
menopause
last menstrual cycle someone has
first week of cycle called
menstruation
menarche
very first menstrual cycle
during menstruation, the endometrium
thins, sheds
days 1-14
pre-ovulatory phase, follicular
what happens in follicular stage
follicle develops, matures on day 14
days 14-28
post-ovulatory phase, luteal
what happens during luteal phase
hormones are produced by corpus lute
when is FSH more abundant
first week
FSH–>–>_____
androstenedione
precursor for when LH acts
androstenedione
FSH primary job
stimulate follicle growth
when does LH spike
day 14
LH primary job female
ovulation
LH–>–>______
aromatase
____+____=estrogen
androstenedione, aromatase
estrogen inhibits
GnRH, FSH, LH
day 14
ovulation
when is estrogen very abundant
day 14
on day 14, estrogen causes a negative or positive feedback loop
positive
estrogen positive feedback loop stimulates more of which hormones
GnRH, FSH, LH
after ovulation, hormones are now produced by
corpus lute
what prevents the body from ending the cycle
little estrogen and progesterone
when the ovary can’t produce progesterone what happens
infertility
fertility window
days 9-16
how long do sperm live
3-5 days
how long do eggs last
12-24 hours
what day is the chance of conception the highest
day 12
why are days 12013 prime fertile days
sperm has time to get to fallopian tube
most fertile day is ___ days before ovulation
2
chance of conception decreases in the beginning or end of cycle
end
how does birth control work
3 weeks of progesterone, makes body think its pregnant, no ovulation
last week, no hormones, triggers period to let you know you aren’t pregnant
menstruation happens at the same time as the ___ spike
FSH
spermatogenesis
process by which sperm develops
where is sperm developed
seminiferous tubules
outer layer of seminiferous tubules is similar to
stem cells of skin
new layers of seminiferous tubules are pushed inward or outward
inward
the core of the seminiferous tubules contains new or old cells
old
DNA needs to be replicated before
mitosis
how many chromosomes do we have
46
chromosomes: ____: 46–>92–>46
mitosis
mitosis end result is _____ daughter cells, ___ copy of DNA
2 identical, full
meiosis end result is ____ daughter cells, ___ copy of DNA
4 non identical, half
chromosomes: ___: 46–>92
meiosis 1
chromosomes: ___: 46–>23
meiosis 2
meiosis is exclusively used for
gametes
how much DNA is in one single cell
6 feet
all DNA in the body can go (length)
to the sun 16 times and back
what wraps around DNA to coil it
histones
how much sperm is released during ejaculation
80-300 million
nucleus rocket
sperm
sperm head parts
acrosome, nucleus
acrosome
enzymes in a liquid
degrades the outside protective layer of the egg
acrosome
most important part of sperm
nucleus
sperm mid piece
mitochondria, energy for propulsion
sperm tail for
propulsion
fertilization purpose is to get
2 gametes to combine
fertilization occurs in
fallopian tube
generalized acrosomal process
fertilization
fertilization step 1
sperm makes contact with egg
fertilization step 2
acrosome reacts with zona pellucida
fertilization step 3
acrosome reacts with perivitelline space
fertilization step 4
plasma membranes of sperm and egg fuse
fertilization step 5
sperm nucleus enters egg
fertilization step 6
cortical granules fuse with egg plasma membrane which renders the vitelline later impenetrable to sperm
how many nucleotides in the genome
3.2 billion
how many total genes
20,000
we share 80% of our genes with ___ and 98% with ____
banana, chimpanzee
where else can DNA be found
mitochondria
what DNA is in the mitochondria
the mothers
we all descended from
“mitochondrial Eve”
how we describe the number of pregnancies for a person
gravida and para
gravida
total # of pregnancies including current one
para
of pregnancies that lasted > 20 weeks
para includes
live births, still births, miscarriages, etc.
what contracts during labor
myometrium
what part of the sperm enters the egg
nucleus
how many days left to implant after ovulation
14
when does implantation happen
6-12 days after ovulation
implantation most likely to happen
8-9 days after ovulation
pregnancy is maintained by what hormone
hCG