Exam 4 Flashcards
(295 cards)
What are the five functions of the skin?
**BRETS
1- BARRIER (btw inside and outside environment)
2- REGULATION of BODY TEMPERATURE (sweating, changes in vessels diameters)
3- EXCRETION (water, sodium salts, urea, nitrogenous waste)
4- TRANSMITS SENSORY INFORMATION (touch, pain, pressure, temperature changes)
5- SYNTHESIS of VITAMIN D (when exposed to sun)
By doing the following, what is the skin acting as ?
- resist mechanical abrasion
- protection against invasion of pathogens
- prevents dehydration (Impermeable to water)
- protects against damage from UV irradiation (melanocytes in skin)
BARRIER
Skin is the LARGEST organ in the body. What are the layers (3) and appendages (3) of skin?
LAYERS
1) Epidermis
- stratified squamous keratinized epithelium
- AVASCULAR
- Derived from ECTODERM
2) Dermis
- dense irregular CT with blood vessels, nerves, glands and hair follicles, upper layer has loose irregular CT
- VASCULAR
- Derived from MESODERM
3) Hypodermis (layer below dermis)
- CT and fat
- superficial fascia
- subcutaneous layer
APPENDAGES
- Glands
- Hair
- Nails
What are the parts of the dermis and what CT is each made of?
1-Basement membrane separates the dermis from the epidermis
- the SUPERFICIAL layer in the dermis
- dermal papillae and epidermal ridges form EVAGINATIONS and INTERDIGITATIONS
- connective tissue filled with fibers, cells and blood vessels
- MEISSNER corpuscles present in dermal papillae of dermis
2- The DEEPER and THICKER layer in dermis
- Few cells present
- TYPE I COLLAGEN
- Blends inferiorly with hypodermis or subcutaneous layer (hypodermis) of superficial fascia
- contains ARTERIOVENOUS ANASTOMOSES (numerous in thick skin of fingers and toes, either bypass capillary to form AV or artery form thick wall called GLOMUS-shunt)
- contains PACINIAN CORPUSCLES (concentric lamellae of collagen fibers surround myelinated axons in pacinian corpuscles)
1) PAPILLARY layer (has dermal papillae, blood vessels, meissner corpuscles)
- LOOSE irregular CT
- has MEISSNER CORPUSCLES
2) RETICULAR layer
- DENSE irregular CT (TYPE 1)
- has PACINIAN CORPUSCLES
**There is no distinct boundary btw papillary and reticular layers
What part of skin form fingerprint?
EPIDERMAL RIDGE of epidermis
- made of stratified squamous keratinizing epithelium
- AVASCULAR
- Derived from ectoderm
Skin can be differentiated into thick vs thin skin. Identify which this is :
- palms of hands and soles of feet
- thick stratum corneum
- stratum LUCIDUM is present
- thicker strata SPINOSUM and GRANULOSUM
- All 5 layers of epidermis present and VISIBLE (corneum, lucidum, granulosum, spinosum, Basale)
- contains sweat glands
- LACKS SMOOTH MUSCLE
THICK SKIN
- Elaborate dermal elevations in thick skin (epidermal ridge)
- Increased bonding btw epidermal basement and dermis PROTECTS thick skin from ABRASION and increased wear compared to thin skin
Skin can be differentiated into thick vs thin skin. Identify which this is :
- All other skin
- thin stratum corneum
- stratum LUCIDUM is ABSENT
- thinner strata spinosum and granulosum
- has basale for production of new skin cells
- only 4 layers of epidermis present
- has arrector pili SMOOTH MUSCLE
THIN SKIN
- dermal papillae (papillary dermis) is not as pronounced
- hair follicles, sebaceous glands and sweat glands are present
Skin is the largest organ of the body and composed of 3 layers (epidermis, dermis and hypodermis) . Epidermis is the top most layer, Derived from ectoderm, is AVASCULAR and has stratified squamous keratinized epithelium. What are the 5 layers of epidermis? (Bottom to top most layer)
1- Stratum basale 2- stratum spinosum 3- stratum granulosum 4- stratum lucidum 5- stratum corneum
From 5 - 1 (Come, Let’s Get Sun Burned)
There are 5 layers of the epidermis. Identify this:
1) Consist of single layer of COLUMNAR to CUBOIDAL CELLS
2) Made up of BASAL cells that has :
- keratinocyte stem cells (increased mitotic activity)
- Melanocytes
- Langerhans cells
- Merkel Cells (sensory receptor cells in skin)
- What connects adjacent cells to each other?
- What connects basal cell to basement membrane ?
STRATUM BASALE
- HEMIDESMOSOMES connect basal cell to basement membrane
- DESMOSOMES connect adjacent basal cells to each other
There are 5 layers of the epidermis. What is the layer and what makes up the layer
- consists of 4-6 rows of cells
- cells SYNTHESIZE KERATIN FILAMENTS that become assembled into tonofilaments
- Spine represent states of Desmosomes attachments to keratin tonofilaments
STRATUM SPINOSUM which is made up of
KERATINOCYTES
- produce keratin (bundles of tonofilament) and LAMELLAR bodies containing lipids
- Take in melanin (pigment) from melanocyte cytoplasmic processes
** DESMOSOMES attach adjacent keratinocytes giving cell a “spiny” appearance
Identify structure
- form junctions btw keratinocytes
- hold keratinocytes together at cytoplasmic extensions
- gives resistance to distortion and abrasion
- connect to intracellular tonofilaments (keratin filament)
DESMoSOMES
There are 5 layers of epidermis . Identify this:
- keratinocytes becomes FLATTENED (squamous)
- DYING CELLS start to lose organelles, nucleus, and melanin granules
- KERATOHYALIN granules accumulate (keratohyalin are aggregates of keratin forming tonofilaments)
- Lamellar bodies (granules) containing lipids released into extracellular space forms WATER BARRIER and seals the skin
STRATUM GRANULOSUM
- 3-5 layers of FLATTENED cells
- secretory granules are not surrounded by a membrane by consist of a protein called FILAGGRIN
- *FILAGGRIN associates and cross-links with bundles of keratin tonofilaments
- Combination of keratin tonofilaments with FILAGGRIN of keratohyalin granules produces keratin through KERATINIZATION
- *KERATIN produced in this process is the soft keratin of skin
- Hydrolytic enzymes disrupt the nucleus and all cytoplasmic organelles which disappear as cells fill with keratin
There are 5 layers of epidermis. Identify this:
- Only found in THICK SKIN
- Dead, flattened keratinocytes filled with KERATIN and devoid of organelles and nucleus
- Translucent and barely visible
- densely packed keratin filaments
STRATUM LUCIDUM
There are 5 layers of epidermis. Identify this:
- Dead keratinocytes are now called SQUAMES (or flakes) COMPLETELY FILLED with KERATIN aggregated by FILAGGRIN
- Surface squames are shed (desquamation) with abrasion and replaced with new cells arising from the deep stratum basale
- MOST SUPERFICIAL layer of skin
- ALL nuclei and organelles have disappeared from cells
STRATUM CORNEUM
How many epidermal cell types are there? What are they?
There are 5 cell types
1- keratinocytes 2- melanocytes 3- Langerhan’s Cells 4- Merkel Cells 5- Stem Cells
Name the epidermal cell types
- primary cell type from base to surface
- produce keratin from tonofilaments and keratohyalin granules
- becomes squames in cornfield layer
**How do the epidermal cells go from stem cells to squamous cells over the progression of diff layer?
KERATINOCYTES
**Progression/differentiation of keratinocytes through the layers
1- stratum BASALE; basal stem cells divde by mitosis to create new keratinocytes
2- stratum SPINOSUM; differentiating cells move away from basement membrane into spinosum
-lamella bodies and tonofilaments begin to form
3- stratum GRANULOSUM; nucleus degenerates and other organelles lost,
- keratohyalin graules with filagrin form keratin aggregates,
- lamella bodies with lipids exocytosis to form water barrier
4- stratum CORNEUM; squamous cells on surface have only keratin
Name the epidermal cell type
- Derived from NEURAL CREST (in basal layer)
- CLEAR cell cytoplasm
- ONLY IN BASAL LAYER
- mostly in THIN SKIN
- located btw stratum basale and stratum spinosum (bottom 2)
- LONG IRREGULAR cytoplasmic or dendritic extensions branch into epidermis
MELANOCYTES
- *PRODUCE MELANIN that is transferred to keratinocytes
- Tyrosinase made by rER, packaged into vesicles by Golgi, and fuse with melanosome vesicles
- Tyrosine - DOPA - Melanin via tyrosinase which is activated by UV light
- Melanin stored in membrane bound granules
- Melanin granules in cytoplasmic processes that insinuate btw keratinocytes
** Tanning INCREASES melanin PRODUCTION, NOT the NUMBER of MELANOCYTES
What is the fate of melanin granules?
What is the difference in melanin in light vs dark skin?
**Melanin granules are transferred to keratinocytes
- melanocytes have cytoplasmic processes btw keratinocytes
- melanin granules phagocytosed into keratinocytes
- melanin granules degraded over time
1) Light skin; melanin is more rapidly DEGRADED, not found in upper layers of spinosum
2) Dark skin; PLENTIFUL MELANIN found in granulosum and may still be found in CORNEUM
Name the epidermal cell type;
- ANTIGEN PRESENTING cell of IMMUNE system
- clear cell cytoplasm
- found in ALL LAYERS ; reside primarily in STRATUM SPINOSUM
LANGERHAN’S CELLS
- dendritic-type cells
- originate from BONE MARROW
- Migrate via blood to skin
Name the epidermal stem cell;
- discriminative touch receptor (mechanoreceptors for sensation)
- clear cell cytoplasm
- ONLY IN BASAL LAYER OF THICK SKIN
- NOT IN THIN SKIN AT ALL
MERKEL CELLS
**If you find merkel cells, know you are in THICK not THIN skin
there are 5 types of epidermal cells. what would stem cells look like and where found?
-dividing stem cell in basal layer of ALL skin (look for MITOTIC FIGURES but rare)
**The 5 epidermal cell types are; keratinocytes, melanocytes, Langerhan’s cells, merkel cells (THICK SKIN ONLY), stem cells
What are the 4 appendages and 2 sensory receptors of skin
**
1- HAIR (develop from surface epithelium of EPIDERMIS and reside in DERMIS)
2- SEBACEOUS GLANDS (produce oily secretion called SEBUM when cells die in sebaceous glands_
- Develop from EPIDERMAL CELLS
- located btw hair follicle and arrector pili muscle
- SEBUM OILS; keep skin smooth, waterproof skin, prevent skin from drying. Give skin some antebacterial protection)
- Numerous glands associated with each hair follicle
3- SWEAT GLANDS
4- NAILS (fingernails are just a specialized region of skin where the stratum CORNEUM is hard keratin)
**
5- Meissner’s cprpuscles
6- Pacinian corpuscles
There are 6 total (appendages and sensory receptors) of the skin.
Be specific
What has arrector pili muscle?
What is over most of body?
What is found in scalp/axilla/pubic?
HAIR 1- Pilosebaceous unit -hair follicle; shaft, bulb, papilla -sebaceous gland -ARRECTOR PILLI MUSCLE (smooth muscle that make hair erect); controlled by the AUTONOMIC NERVOUS SYSTEM, CONTRACT during strong EMOTIONS of fear and cold, contraction erects hair shaft, depresses skin where it inserts and produces a small bump on the surface of skin called GOOSE BUMP, contraction also forces SEBUM from sebaceous gland onto the hair follicle and skin)
2- TERMINAL HAIR
-thick in SCALP, AXILLA, pubic area
3- VELLUS HAIR
-fine, short and silky; OVER MOST OF the BODY
Hair is one of the appendages of skin. It can be differentiated into pilosebaceous unit, terminal and vellus hair. Pilosebaceous unit is made up of hair follicle, sebaceous gland and arrector pili muscle. The structure of hair follicle is made of a shaft, bulb and papilla.
What are the 5 layers of hair follicle /(from outermost to innermost layer)
1- CTS (connective tissue sheath)
2- GLASSY membrane (thick basement membrane for external root sheath)
3- ERS (external root sheath)
- downgrowth of the epidermis
4- IRS (internal root sheath)
- surrounds the beginning of the hair shaft at the hair bulb
- ends at the level of the sebaceous glands
5- SHAFT (has cuticle, cortex and medulla)