Exam 4 - Antivirals (Kays) Flashcards Preview

Therapeutics V Spring 2019 (P3 Spring) > Exam 4 - Antivirals (Kays) > Flashcards

Flashcards in Exam 4 - Antivirals (Kays) Deck (34):
1

Acyclovir:
______ in HSV and VZV converts acyclovir to acyclovir monophosphate

viral thymidine kinase

2

Acyclovir:
_______ convert acyclovir monophosphate to acyclovir diphosphate then to triphosphate

humane cellular kinases

3

Acyclovir:
MOA?

inhibits viral DNA replication
competitively inhibits viral DNA pol

4

Acyclovir:
Resistance mechanisms against it seen in HSV and VZV?

absent/altered production of viral thymidine kinase (aka TK deficient)
and altered viral DNA pol

5

Acyclovir:
Bioavailabiltiy ______ with increasing dose

decreases!!

6

Acyclovir:
adjust for renal dysfunction??

yasss

7

Acyclovir:
ADEs?

Oral is well tolerated
Nephrotoxicity (crystalline)
Neurotoxic
Thrombophlebitis with IV form

8

Famciclovir/Penciclovir:
does it need to be activated by thymidine kinase still?

yeet

9

Famciclovir/Penciclovir:
Dose adjust in renal dysfunction?

yeet

10

Ganciclovir:
Dose adjust in renal dysfunction?

yeet

11

main ADE with ganciclovir?

bone marrow suppression

12

main ADE with valanciclovir?

hematologic toxicity

13

Letermovir:
used mainly for what disease state?

CMV PROPHYLAXIS

14

Letermovir:
Renally adjust in dysfunction?

not really...
only if below 10 mL/min

15

Foscarnet:
10-20% of drug gets sequestered where?

the bone

16

Main ADEs with foscarnet?

Nephrotoxicity
(hydrate pts!!)
hypocalcemia/phosphotemia

17

Foscarnet:
adjust for renal dysfunction?

Yeet

18

what are the neuramindase inhibitors

zanamivir
oseltamivir
peramivir

19

MOA of amantadine and rimantadine?

block uncoating of viral RNA within the host cell

20

Which neuramindase inhibitor is administered via inhalation?

zanamivir

21

which neuramindase inhibitor is given IV?

Peramivir

22

which neuramindase inhibitor is given orally

oseltamivir

23

neuramindase typically helps the virus with what step?

typically helps/promotes the release of the virus from infected cells

24

neuramindase is typically found on the surface of human or viral cells?

viral

25

neuramindase inhibitor attach to ______ inside _____

to virus; inside inside host cell

26

which neuramindase inhibitor is approved for flu treatment patients 7 and above and can do prophylaxis for ages 5 and above

zanamivir...kids gotta be able to inhale it

27

Zanamivir: not recommended for who?

people under 7...
and pts with asthma or COPD

28

TREATMENT regimen for oseltamavir

BID x5 days

29

ChemoPROPHYLAXIS regimen for oseltamivir

QD x 10 days

30

Oseltamivir is approved for treatment of flu for patients above what age?

above 2 weeks

31

Oseltamivir is approved for prophylaxis of flu for patients above what age?

1 year of age

32

Live attenuated vaccine and zanamivir/oseltamivir relation?

do not do vaccine until 48 hours AFTER stop of zanamivir/oseltamivir
or do not give zanamivir/oseltamivir until 2 weeks after live vaccine

33

which neuramindase inhibitor do you have to renally adjust?

oseltamivir

34

how many doses to do of peramivir

just one dose!!