Exam 4 - Lec 52-53 Antipsychotics Watt Flashcards
based on mech of LSD and mescaline
a. dopamine NT hypothesis
b. serotonin NT hypothesis
c. glutamate NT hypothesis
b. serotonin NT hypothesis
based on phencyclidine and ketamine
a. dopamine NT hypothesis
b. serotonin NT hypothesis
c. glutamate NT hypothesis
c. glutamate NT hypothesis
at what dose will risperidone cause EPS side effects in most patients?
a. 0.5 mg
b. 1 mg
c. 2 mg
d. 6 mg
e. 10 mg
d. 6 mg
rating scale of tardive dyskinesia
AIMS (abnormal invol movement scale)
which VMAT inhibitor is for TD and Huntington’s chorea?
a. tetrabenazine
b. valbenazine
c. deutetrabenazine
c. deutetrabenazine
EPS is due to ____ antagonism
D2
what syndrome is associated with EPS sx with fever, impaired cognition, and muscle rigidity?
NMS (neuroleptic malignant syndrome)
Tx of NMS
restore dopamine balance (3 drug options: DA agonists, diazepam, or dantrolene)
how long does it take antipsychotics to have max efficacy for tx of psychosis?
6 weeks to 6 months
pimozide use
a. psychosis
b. Tourette’s tics
c. Huntington’s chorea
d. NMS
b. Tourette’s tics
_______ and _______ are noncompetitive inhibs of NMDA receptors and exacerbate psychosis and cognition deficits
phencyclidine; ketamine
why are D2 receptors a more effective drug target than D1 receptors for schizophrenia?
there is a perfect correlation between binding potency and clinical effectiveness for D2 (ability of drugs to bind to D2 is predictable)
loss of accommodation, dry mouth, difficulty urinating, constipation
a. muscarinic cholinoreceptor blockade
b. alpha adrenoreceptor blockade
c. dopamine receptor blockade
d. supersensitivity of dopamine receptors
e. histamine receptor blockade
a. muscarinic cholinoreceptor blockade
typical antipsychotics have more movement problems, inc EPS and TD due to ?
strong D2 block
1st antipsychotic
chlorpromazine
