Exam 4 - Stahelin Influenza virus (study)

Question 1

Describe the influenza virus life cycle. Which steps are inhibited by anti-flu drugs?

Answer 1

Virus buds out to release virion which allows continued viral replication. Neuraminidase cleaves the virion from the receptor allowing this action. NA inhibitor drugs block this step, preventing further virion release and viral replication.

Question 2

Baloxavir
MOA:
MOR:
SOA:

Answer 2

MOA: inhibits viral “cap-snatching” (blocks transcriptions)
MOR: N/A
SOA: flu within 1st 48h of sx

Question 3

Oseltamivir
MOA:
MOR:
SOA:

Answer 3

MOA: NA inhibitor
MOR: mutations in the active site of neuraminidase
SOA: flu A and B (better against A)

Question 4

Zanamavir
MOA:
MOR:
SOA:

Answer 4

MOA: NA inhibitor
MOR: mutations in the active site of neuraminidase
SOA: flu A and B (inhaled option)

Question 5

Peramivir
MOA:
MOR:
SOA:

Answer 5

MOA: NA inhibitor
MOR: N/A
SOA: flu A and B (IV option)