Exam 5 Flashcards

(37 cards)

1
Q

Gastrulation

A

the development of germ layers from a blastula

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2
Q

What are the germ layers? (3)

A
  • endoderm
  • mesoderm
  • ectoderm
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3
Q

Endoderm (2)

A
  • inner layer
  • gives rise to digestive and respiratory systems
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4
Q

Mesoderm (2)

A
  • middle layer
  • gives rise to bone, muscle, and connective tissue
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5
Q

Ectoderm (2)

A
  • outer layer
  • gives rise to skin and the nervous system
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6
Q

How does the ectoderm form the nervous system?

A

it closes in upon itself to form the neural tube

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7
Q

Neural Tube

A

the precursor to brain and spinal cord

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8
Q

What are the stages of neuronal development? (5)

A

1) Cell Birth
2) Migration
3) Differentiation
4) Axon Growth
5) Cell Death

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9
Q

Cell Birth

A

the ventricular zone contains newly born cells that give rise to neural progenitor cells

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10
Q

Neural Progenitor Cells

A

soon-to-be brain cells

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11
Q

Migration (2)

A
  • neural progenitor cells leave the ventricular zone and migrate through an intermediate zone of the neural tube before reaching their destination
  • guided by the radial glial cells
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12
Q

Differentiation

A

the cell takes on the shape and function of other cells in the region

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13
Q

Axon Growth

A

chemoattractant and chemorepellent signals combine with cell adhesion molecules to guide the movement of the growth cone and its axon

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14
Q

Chemorepellants

A

prevent the developing axon from veering off course

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15
Q

Cell Death

A

several cells are lost through apoptosis

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16
Q

Apoptosis

A

programed cell death

17
Q

Nerve Growth Factor (2)

A
  • a protein that prevents apoptosis
  • promotes neuronal growth
18
Q

What does gray matter plasticity compose of? (3)

A
  • axon sprouting
  • dendritic branching
  • neurogenesis
19
Q

Synaptogenesis (2)

A
  • the formation of synapses
  • an explosive increase in synapses during the early postnatal period
20
Q

Critical Period

A

a window of time typically in early development

21
Q

Why are critical systems in early development?

A

it is when a system is open to structuring/restructuring

22
Q

What are factors that affect critical periods? (2)

23
Q

Timing

A

biological readiness

24
Q

Input

A

necessary to trigger the opening

25
What happens if an eye is closed during a critical period?
it prevent the formation of the visual dominance columns before they have a chance to develop
26
When is the effect of eye closure weaker?
when it is done later
27
Which synapses are pruned during development?
excitatory connections
28
What is responsible for opening critical periods?
GABA cells
29
What happens when synapses are pruned? (2)
- there is a shift in balance from more excitatory to more inhibitory synapses - consolidation of learning memory
30
How are critical periods stabilized and closed? (2)
- myelination of axons - perineuronal nets
31
Myelination of Axons
formation of myelin creates physical barriers to sprouting/axonal growth
32
Perineuronal Nets
lattice of molecules consisting of proteins and sugars that wrap around GABA cells as they mature
33
Plasticity
a progress by which experiences reorganize neural connections/pathways
34
What are signs of Alzheimer's Disease? (2)
- increase in amyloid plaques - neurofibrillary tangles
35
Amyloid Plaques
clusters of beta amyloid protein located within extracellular spaces in the brain
36
Neurofibrillary Tangles
clusters of misfolded tau protein located inside of neurons
37
Which of the two signs of Alzheimer's disease more harmful?
the tangles