exam 5 2020

Question 1

Enfuvitide is an HIV fusion inhibitor that

Answer 1

binds to gp41 `

Question 2

The drug amantidine blocks infection by influenza A virus by

Answer 2

affecting the function of the viral M2 protein

Question 3

How does foscarnet, a drug for treating herpesvirus infections, act as an antiviral?

Answer 3

is a non-nucleoside inhibitor of viral DNA polymerase

Question 4

How does remdesivir, a drug for treating COVID-19, act as an antiviral?

Answer 4

s a nucleoside analog that inhibits viral RNA-dependent RNA polymerase

Question 5

How does the monoclonal antibody drug, approved in November 2020 for treating COVID-19, act as an antiviral?

Answer 5

binds spike (S) protein of SARS-CoV-2, blockingvirions from interacting with ACE2 receptor

Question 6

For which disease agent is the production of secretory antibodies (IgA) part of the “correlates of protection?”

Answer 6

rotavirus

Question 7

Which of the following is not a use of passive immunization?

Answer 7

to create long-lived immunity

Question 8

Which of the following is true about variant Creutzfeldt-Jakob disease (variant CJD)?

Answer 8

the median duration of the illness in 13-14 months

Question 9

This fungus produces a thick capsule, which is observed under the microscope with India ink staining?

Answer 9

cyrptococcus neoformans

Question 10

Which anti-fungal works by inhibiting cytochrome P450-dependent 14-alpha-lanosterol demethylation?

Answer 10

fluconazole

Question 11

Which anti-fungal binds ergosterol in fungal membranes and alters membrane permeability?

Answer 11

nystatin

Question 12

In which pathogen will you find cell walls made ofpolymers of N-acetyl-glucosamine?

Answer 12

Coccidioides immitis

Question 13

Which form of oral candidiasis involves superficial fungal growth with easily removeable plaques of fungi?

Answer 13

acute pseudomembranous

Question 14

Salmonella-Shigella agar (SS) is an example of which type of culture medium used for diagnosis of a bacterial infection?

Answer 14

selective medium

Question 15

What is the order of components for an ELISA test for microbial antigen detection in a patient blood serum sample? Order reads
right to left in answer choices. Step K = enzyme substrate added Step M = patient serum added Step X = enzyme conjugated antibody specific to antigen added

Answer 15

laboratory produced antibody specific for antigen bound to well surface; Step M; Step X; Step K

Question 16

What the shortest time to kill all microbes in a suspension at a specific temperature?

Answer 16

thermal death time

Question 17

What is the Spaulding Classification category of a blood pressure cuff?

Answer 17

non-critical

Question 18

What compounds are commonly used as hospital and household disinfectants, are tuberculocidal, but have a disagreeable odor
and cause skin irritation?

Answer 18

phenolics

Question 19

What does the term R0 mean with respect to the epidemiology of an infectious disease?

Answer 19

the number of secondary cases that one case of the disease would produce in a completely susceptible population

Question 20

What disease is caused by the conversion of a normal human protein to a form that aggregates as amyloid fibrils?

Answer 20

kuru

Question 21

An altered form of the PrP protein (PrPSc) is the basis for Creutzfeldt-Jakob disease. What is the function of the normal PrP protein
(PrPC)in neurons and glial cells?

Answer 21

a regulator of ion channels and neurotransmitter receptors

Question 22

What strategy has been used to create a successful vaccine against Haemophilus influenzae type b (Hib)?

Answer 22

creating a vaccine from Hib capsular polysaccharride linked to a diptheria toxiod molecule as the antigens