Exam 5 - Neuro Flashcards
(64 cards)
What are the pain sensitive areas of the brain?
What is a migraine?
An episodic vascular disorder manifested by pain in the head & often accompanied by anorexia, photophobia, nausea with or without vomiting.
What are the 3 phases of a migraine?
- Early (prodromal) phase cerebral arterial constriction and a rise in serotonin levels.
- Second phase - dilation, stretching, & swelling of intracranial & extracranial vessels & fall in level of serotonin. Congestion of nasal mucus & conjunctiva.
- Final phase - neck & scalp muscles may contract.
What can trigger migraines?
Migraine in women tend to occur during periods of premenstrual tension & fluid retention.
–Estrogen & progesterone levels are not changed
–onset in premenstrual period is related to estrogen rather than progesterone.
–Stress
–Missing meals
–Tyramine-rich foods
Describe the phases of a migraine with aura
1st phase - an aura typically develops over several minutes and does not last longer than one hour.
- Prodromal phase consists of transient focal neurological dysfunction often visual such as spots, lines, zigzags
- May have confusion, vertigo, numbness, tingling of lips
2nd phase - HA, N/V. Pain begins in one area and spreads
3rd phase - pain changes from throbbing to dull
Describe a migraine without aura
- Not present or not recognized
- If early warning - mood change such as irritability, euphoria, or depression
- Begins in one area & spreads to entire side. May be bilateral.
- May have N/V.
- May start in early AM, during periods of stress, premenstrual tension
What drugs are used as preventive therapy for migraines?
- Beta-adrenergic blockers (propranolol, nadolol, or atenolol)
- Anticonvulsant such as gabapentin (neurontin), topiramate (Topamax), valproate (Depacon)
- Lamotrigine (Lamictal)- migraines with auras
- Antidepressants - tricyclic’s such as amitriptyline (Elavil) or nortriptyline (pamelor)
- Not first line - has S/E such as hypotension, drowsiness
What are some treatments for migraines after the headache has started?
- Ergotamine derivatives – useful for migraines lasting longer than 48 hours; D.H.E. available in an injectable & nasal spray
- NSAIDs or combination drugs of tylenol, ASA, and caffeine
- Antiemetic - compazine
- Triptans (zomig, imitrx, axert, etc) - PO or SC.
- Stimulates 5-HT1 (serotonin) receptors causing cranial vasoconstriction, and also widespread vasoconstriction
- contraindicated in pt. With ischemic heart disease or Prinzmetal’s angina because of the potential for coronary vasospasms.
What are some alternative treatment measures for pain releif from migraines?
- Beginning of migraine - pt. Lay down in a quiet, darkened room.
- Modify potential triggering factors
- foods such as MSG, mature cheese, sausage, sauerkraut, dark chocolate, citrus fruit, red wine
- odors - cigarettes, cigar, paint, perfumes, gasoline
- Decrease stress in life - biofeedback, etc
- Exercise helps
What are some characteristics of cluster headaches?
- Pain is unilateral
- oculofrontal or oculotemporal
- Pain described as boring, excruciating, nonthrobbing
- HA usually occur every 8-12 up to 24 h daily at the same time for about 6-8 weeks, usually start in the morning
- Then period of remission (9 mo to 1 yr), to return
- Average duration of the HA is 10-45 min.
What are some signs and symptoms of cluster headaches?
- Other S/S- ipsilateral tearing of eye, rhinorrhea, congestion, ptosis, miosis. Bradycardia, flushing, pallor, inc. intraocular pressure, inc. skin temp.
- Pain may radiate to forehead, temple, or cheek
- Temporal artery may be tender & prominent.
- Pt. Will generally pace, walk, or rock –> Patient can’t sit still, they are trying to block the pain.
What would you assess for in a cluster headache?
§Precipitating factors
§Duration of the HA
§Frequency in 24 h
§# of weeks before remission
§characteristics of the HA
§
§Characteristics:
–origin of HA tenderness of arteries facial flushing
–spread of HA bradycardia tearing, rhinorrhea
–Pacing, rocking behavior
What are some medications used to treat cluster headaches?
Medications
- Oxygen – briefly inhale 100% O2 via mask at minimum of 7 l/min
- Reduces cerebral blood flow, helps manage pain
- Triptans
Preventive medications
–Calcium channel blockers
–Corticosteroids
–Lithium
–Nerve block
–Ergots
–Melatonin
–Wear sunglasses, O2 therapy
What are seizures and what are the 3 types?
Seizures are an abnormal, sudden excessive discharge of electrical activity within the brain.
Types:
- Generalized
- Partial
- Unclassified
What causes seizures?
- metabolic disorders
- tumor
- acute ETOH withdrawal
- CVA electrolyte disturbances
- Infection
What can cause primary seizures?
- usually inherited & age-related.
- Scar tissue from a head injury
- vascular disease
- brain tumors
- aneurysm
- OI’s from AIDS
- Meningitis
- Stroke
What causes secondary seizures?
- metabolic disorders
- electrolyte disorders
- hyperkalemia
- hypoglycemia
- drug withdrawal
- acute ETOH withdrawal
- water intoxication
- kidney or liver failure
What are some precipitating factors for seizures?
- increased physical or emotional stress
- increased physical activity
- alcohol or caffeine consumption
- certain foods or chemicals
What are some characteristics of partial seizures?
- Seizures that initially affect one specific area in one hemisphere of the brain
- May or may not cause an alterationof consciousness
- Symptoms can include muscle twitching, repetitive motions, and the appearance of “daydreaming”
- Partial seizures can become generalized seizures
What are some characteristics of generalized seizures?
- Seizures that affect both hemispheres of the brain
- Result in a loss of consciousness
- Symptoms can include blank stares, falling to the floor, sudden muscle jerks, and repetitive stiffening and relaxing of muscles
What are the 2 types of partial seizures?
–Simple partial
- Patient remains conscious throughout episode. Patients often have an aura or a déjà vu phenomenon with perception of an offensive smell or sudden pain
–Complex partial
- patient losses consciousness for several seconds. May have “automatisms” such as lip smacking, patting, picking at clothes, etc. (look like they are having a daydream)
–Jacksonian seizure- focal seizure extends into adjacent area (goes from one part of the body towards the spinal cord)
–Usually in the temporal lobe - psychomotor seizures
What are the 4 types of generalized seizures?
- tonic-clonic - “grand mal”
* begins with tonic phase characterized by stiffening or rigidity of the muscles, particularly of arms & legs & immediate loss of consciousness. Followed by clonic (rhythmic) jerking of all extremities. - Absence - “Petit mal”
- Brief period of loss of consciousness like day dreaming. More common in children.
- During Seizure:
- Vacant stare
- Eyes roll upward
- Lack of response
- Myoclonic - brief jerking or stiffening of the extremities which occur singly or in groups of muscles.
- Atonic - sudden loss of muscle tone, pt. falls, pt. is unconscious
What are the different phases of tonic-clonic seizures?
1. Prodromal Phase
- Irritability/tension precede several hours to days
- Aura with or without warning
- Sudden loss of consciousness
2. Tonic Phase
- 1minute- average 15 seconds
- Major tonic contraction- increased tonus
- Body stiffens – legs & arms extended
- Person falls if standing
- Jaw snaps shut, tongue bitten
- Bowel/bladder empties
- Apnea for several seconds (pale, cyanotic)
3. Clonic Phase
- 30 seconds plus
- Inhibitory neurons active -> interrupting tonic seizure with clonic activity
- Violent, rhythmic muscular contractions
- Hyperventilate
- Face contorted, eyes roll (becuase both hemisphere’s are involved)
- Excessive salivation, frothing of the mouth
- Profuse sweating
- tachycardia
4. Postictal phase
- Cease fire
- Extremities limp
- Breathing is quiet
- Pupils equal or unequal response to light reflex
- Confused, disoriented, amnesic
- Generalized aching
- Fatigue
- Deep sleep for several hours
- Todd’s paralysis - not permanent, prolonged period of weakness involving 1 or more extremity.
How would you respond to a tonic-clonic seizure?
Your primary responsibility during a seizure is to make sure the seizing student is as safe as possible. Here are some steps you can take:
- Remain calm and let the seizure happen. You will not be
- able to stop a seizure. Most last from 30 seconds to 2 minutes
- Help the student to the floor and place something
- soft under his or her head. Do not hold the student down
- Move aside any objects that may cause injury
- Do not put anything in the student’s mouth. Contrary to popular belief, a person who’s seizing cannot swallow his tongue
- Help maintain the student’s dignity by moving onlookers away
- Once the jerking movements have stopped, lay the student on his or her side. This will help prevent choking should the student vomit
- –While regaining consciousness, the student will likely be confused and disoriented. Reassure the student that he or she is safe
- –Stay with the student and do not let him or her eat or drink until
- fully alert