Exam 6 - LRTI Flashcards

(81 cards)

1
Q

What 3 things/areas does the lower respiratory tract involve?

A

1) Bronchi
2) Bronchioles and alveoli
3) Lungs

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2
Q

How do you get bacterial pneumonia?

A

1) Inhalation of contaminated air droplets

2) Aspiration

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3
Q

Name the 4 complications of bacterial pneumonia.

A

1) Pleuritis
2) Abscess
3) Bronchiectasis
4) Sepsis

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4
Q

Name frequent co-morbid conditions associated with bacterial pneumonia (7).

A

1) Asthma
2) COPD
3) DM
4) HF
5) Alzheimer’s
6) Influenza
7) COVID-19

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5
Q

Name the 3 classifications of bacterial pneumonia.

A

1) Hospital Acquired Pneumonia (HAP) - s/s after a minimum of 48 hours in the hospital
2) Ventilator Associated Pneumonia (VAP) - after 48-72 hours of intubation
3) Community Acquired Pneumonia (CAP) - none of the above, resides in the community

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6
Q

What it is primary bacteria in CAP?

A

Strep. pneumo

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7
Q

What are the 3 bacteria species/classes that present in CAP?

A

1) Strep pnemo
2) H. flu
3) Mycoplasma pneumoniae

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8
Q

Name the 5 total bacteria that can be seen in CAP.

A

1) Strep pneumo
2) H. flu
3) Mycoplasma pneumo
4) Legionella pneumophilia - uncommon
5) Klebsiella pneumo - alcoholism

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9
Q

Name the 7 types of bacteria that can be seen in HAP/VAP.

A

1) Strep pneumo
2) Legionella - atypical bacteria
3) Klebsiella
4) Pseudomonas aeruginosa
5) E. coli
6) Staph aureus
7) MRSA

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10
Q

Name the “Typical” s/s of bacterial pneumonia (5).

A

1) Cough with sputum production
2) Fever
3) Chills
4) Pleuritic chest pain - pain in side with deep inspiration
5) SOB

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11
Q

Name the “Atypical” s/s of bacterial pneumonia (3).

A

1) HA
2) Low-grade fever or afebrile
3) Dry, persistent cough

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12
Q

Name the physical findings of bacterial pneumonia (6).

A

1) Distant or coarse breath sounds
2) Rhales
3) Inspiratory crackles
4) Dullness to percussion
5) Tachypnea
6) Tachycardia

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13
Q

What is the GOLD STANDARD in diagnosis bacterial pneumonia?

A

Radiographic evidence

  • Chest x-ray
  • CT scan
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14
Q

When is a sputum culture obtained?

A

Severe infections

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15
Q

What is meant by “left shift” in WBC count?

A

Increase in bands

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16
Q

What does an elevated/positive PCT indicate?

A

Bacterial infection

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17
Q

Name three scenarios that can elevate PCT.

A

1) Thyroid cancer
2) COVID-19
3) Kidney failure

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18
Q

What is the name of the lab value that is a biomarker of bacterial infection?

A

PCT - procalcitonin

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19
Q

What value is indicative of a bacterial infection with PCT values?

A

> 0.25 ng/mL

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20
Q

What do you use PCT levels for in a patient with an infection?

A

Deciding to escalate or de-escalate antibiotics

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21
Q

T/F: PCT can be used to decide whether to start antibiotics or not.

A

FALSE - PCT should NOT be used to decide whether to start antibiotics or not

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22
Q

Streptococcus pneumoniae is gram _____.

A

Streptococcus pneumoniae is gram POSITIVE.

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23
Q

Name the 4 general approaches to management of bacterial pneumonia.

A

1) Oxygenate
- If O2 below 92%, then need supplemental oxygen

2) Hydrate
- Water is the best mucolytic

3) Analgestics/antipyretics
- IBU or APAP - caution with suppressing fever and using that as an indication for changing/stopping antibiotics
- Morphine, Percocet for pain so that patients can breath

4) Antibiotics

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24
Q

Why can you not use Daptomycin for MRSA pneumonia?

A

Because Daptomycin cannot be used in the lungs

-Broken down by enzymes in the lungs

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25
In which type of bacterial pneumonia is CURB-65 used?
CAP ONLY!
26
What is CURB-65 used for?
To assess the severity of CAP
27
What assessment tool is used to assess severity of CAP?
CURB-65
28
Name the 6 risk factors for drug resistance in bacterial pneumonia.
1) Age >65 2) Beta lactam therapy within 3 months 3) Alcoholism 4) Immunosuppressive therapy/disease 5) Multiple medical co-morbidities 6) Exposure to a child in day care
29
List the 3 drugs used in OUTPATIENT treatment of CAP in ADULTS WITHOUT co-morbid conditions ("ADA").
One single agent below: 1) Azithromycin 500 mg po once, then 250 mg qd - QT interval prolongation 2) Doxycycline 100 mg po bid - CI during PG 3) Amoxicillin 1 g po tid
30
List 2 combinations of meds for OUTPATIENT treatment of CAP in ADULTS WITH co-morbid conditions.
1) Amox/Clav (Augmentin) - 500/125 po TID - 875 or 2000 mg/125 po BID 2) Second or third gen CPN - Cefdinir - Cefpodoxime One of the above WITH either Azithromycin, Clarithromycin, or Doxycycline
31
What does Augmentin cover?
Strep | H. flu
32
T/F: FQNs cover mycoplasma.
TRUE
33
Why are Azithromycin, Clarithromycin, or Doxycycline added in outpatient treatment of CAP in patients with co-morbidities?
Cover Mycoplasma
34
T/F: Ceftibuten is a 3rd generation CPN with good staph coverage.
FALSE - poor staph coverage
35
List the 3 drugs and additional drug used in INPATIENT treatment in ADULTS WITHOUT risk for Pseudomonas and MRSA with non-severe infection.
1) Ampicillin/Sulbactam (Unasyn) 2) Ceftriaxone - 3rd gen 3) Ceftaroline - 5th gen Any of the above AND Azithromycin, Clarithromycin, or Doxycycline
36
List the combination of meds used in a severe infection for INPATIENT treatment of CAP in ADULTS WITHOUT Pseudomonas and MRSA.
Levofloxacin OR Moxifloxacin PLUS a beta-lactam (Amp/Sulbactam, Ceftriaxone, Ceftaroline)
37
Name the INPATIENT treatment for CAP in ADULTS with risk for Pseudomonas and MRSA.
MRSA -Vancomycin, Linezolid, or Ceftaroline Pseudomonas -Pip/tazo, Cefepime (4th gen), Ceftazidime (3rd gen) or Aztreonam (resistance)
38
Name the drugs that are available for pts with HAP or VAP.
Cefepime OR Meropenem OR Pip/Tazo PLUS Cipro OR Levo OR Aminoglycoside One from each group above PLUS Vancomycin
39
What do you save Meropenem for?
ESBL | Severe PCN allergy
40
T/F: Cefepime is less nephrotoxic than Zosyn.
TRUE
41
Cefepime is which class of CPN?
4th gen
42
T/F: Zosyn has broad coverage.
TRUE
43
What should you add to Cefepime if you think there are anaerobes involved?
Metronidazole, Clindamycin
44
Which has better gram negative coverage, Cipro or Levo?
CIPRO
45
What are useful parameters to monitor improvement of bacterial pneumonia (6)?
1) Decreased temp 2) Decreased WBC 3) Decreased cough and chest pain 4) Rising O2 saturation 5) Decreased RR 6) Decreasing PCT
46
Which antibiotics have concentrations with PO approximate IV (going from IV to PO)? (7)
1) Doxycycline 2) Ofloxacin, Cipro, Levo 3) Metronidazole 4) Clindamycin 5) TMP/SMX
47
What are the requirements to switch from IV to PO therapy (6)?
1) Able to ingest PO meds 2) HR <100, systolic BP >90 3) O2 sat >90% 4) RR <25 per minute 5) Temperature <100.9 F 6) Return to cognitive baseline
48
What is the duration of treatment for CAP?
5-7 days
49
What is the duration of treatment for VAP or HAP?
7 days
50
What 3 vaccines are prevention for bacterial pneumonia?
1) Annual influenza 2) PCV20 3) COVID-19
51
List management for moderate-severe COVID-19 pneumonia (5).
1) Oxygen supplementation 2) Conservative fluid management 3) Dexamethasone for pts needing oxygen 4) Remdesivir for pts needing oxygen or at risk of severe disease 5) DVT/PE prophylaxis with Enoxaparin
52
What is outpatient treatment for CAP in infants/pre-school peds patients?
Amoxicillin
53
What is inpatient treatment for infant/pre-school peds pts with CAP?
Ceftriaxone OR Cefotaxime | -both 3rd gen
54
What is outpatient treatment for school age children with CAP?
Macrolide
55
What is inpatient treatment for school age children with CAP?
Beta-lactam + Macrolide
56
What is the treatment duration for peds patients with CAP?
7-10 days
57
What is the preferred parenteral for MSSA?
Cefazolin (1st gen)
58
What is oral step down for MSSA?
Cefazolin to Cephalexin (1st gen) OR Clindamycin
59
What is the preferred parenteral for MRSA?
Vancomycin
60
What is the step down oral therapy for MRSA?
Vancomycin to Clindamycin OR Linezolid
61
What is the preferred parenteral for Group A Strep?
Pen G
62
What is oral step down therapy for Group A Strep?
Pen G to Amoxicillin OR Clindamycin
63
What is the preferred parenteral for H. flu?
Ampicillin or Ceftriaxone
64
What is step down oral therapy for H. flu?
Ampicillin or Ceftriaxone to Amoxicillin OR 2nd/3rd gen CPN
65
What is preferred parenteral for Mycoplasma pneumoniae?
Azithromycin
66
What is oral step down therapy for Mycoplasma?
Azithromycin to Azithromycin OR Clarithromycin OR Levo
67
What is the term for acute exacerbation of chronic bronchitis?
Acute bronchitis
68
How long is the duration of cough in acute bronchitis?
<2-3 weeks
69
T/F: Acute bronchitis is usually self-limiting.
TRUE
70
What are treatment options for acute bronchitis?
Supportive therapy - APAP/IBU - Cough suppressant at night
71
When is acute bronchitis referred for antibiotic therapy (5)?
``` Febrile HR >100 Elevated PCT Symptoms persist beyond 2 weeks Age >65 ```
72
How long is the presence of cough in chronic bronchitis?
Cough with sputum production for a minimum of 3 months for 2 consecutive years
73
Name the 3 bacterial pathogens present in complicated acute bronchitis and AECB (Acute Exacerbation of Chronic Bronchitis)?
1) H. flu 2) S. pneumoniae 3) M. catarrhalis
74
Name the 4 types of antibiotics that can be used to treat complicated acute bronchitis and AECB.
1) Macrolides 2) Doxycycline 3) Amox/Clav 4) 2nd/3rd gen CPN
75
T/F: Bronchiolitis is not self-limiting.
FALSE - bronchiolitis is usually self-limiting
76
During what months/season does bronchiolitis occur?
November - April
77
What are the 3 pathogens for bronchiolitis?
1) RSV 2) Parainfluenza 3) Rhinovirus
78
What nebulized treatment is superior to beta 2 agonists in treatment of bronchiolitis?
Nebulized Epinephrine
79
What is Ribavarin indicated in?
Bronchiolitis treatment
80
Who receives RSV prophylaxis?
BABIES - Neonates
81
What is Palivizumab (Synagis) indicated for?
RSV prophylaxis