Exam 7 Flashcards
(256 cards)
HLA common type
B27, usually class II MHC
Central tolerance
Cells expressing auto antibodies are marked and destroyed through apoptosis
Clonal anergy
Inactive T cells that have not encountered antigen
Immunological ignorance
Lack of antigen antibody encounter
Active regulation
Surveillance for self reacting antibodie
Rheumatoid arthritis definition
Chronic and systemic inflammatory dz affecting synovial tissues
Synovitis of multiple joints
Genetic risk factor for RA
HLA with shared epitope, 4x great risk of RA, but only present in 30% of population
How long are autoantibodies present in RA before onset of sx?
5-10 years
RA pathophysiology
Synovial fluid increases as synovial tissue proliferates, pannus develops
Pannus infiltrates adjacent structures and destroys them
RA joint symptoms
Early pain and stiffness
Symmetric swelling and pain of multiple joints
Worse with activity, worse in morning
Joint deformities in RA in the hands
Swan neck- hyperextension of PIP
Boutonnière- hyperflexion of PIP
Ulnar deviation of MCP
Other RA symptoms
*constitutional symptoms
Rheumatoid nodules (over bony prominences, bursae, tendons)
Dry eye, scleral nodules
Felty syndrome
Found in RA
RA, splenomegaly, neutropenia
RA diagnostics
Anti-CCP (most correlated and more specific)
RF (not as specific)
RA imaging
Early- soft tissue swelling of wrists and feet, juxta-articular demineralization
Late- joint space narrowing, bony erosions
What does RA have that OA doesn’t?
MCP involvement Systemic symptoms Extra articular symptoms Persistent morning stiffness Symmetrical joint involvement Erosions on x rays Increased ESR, CRP, RF, and anti-CCP
What is more specific to OA vs. RA?
Asymmetrical joint involvement
Osteophytes on x ray
3 types of juvenile idiopathic arthritis
Oligoarticular
Polyarticular
Systemic onset
What is an ocular risk of all JIA patients?
Uveitis
JIA diagnosis
Effusion noticed acutely by parents
Pain and stiffness that restricts motion
Arthritis onset slow
JIA exam
Inflammation, erythema, tenderness, effusion
Still disease general
Related to chronic juvenile arthritis
Young adult onset
Still disease symptoms
High fevers
Sore throat
Evanescent rash
Destructive arthritis
Dramatic increased WBC, ferritin
What are the lupus criteria?
- Malar rash
- Discoid rash
- Photosensitivity
- Oral ulcers
- Arthritis
- Serositis
- Kidney disease
- Neurological disease
- Hematologic disorders
- Immunologic abnormalities
- Positive ANA