Exam IV - Uterine Flashcards Preview

Pharm Exam IV (KAM) > Exam IV - Uterine > Flashcards

Flashcards in Exam IV - Uterine Deck (22):
1

Oxytocin
Indications

1. Induce labor for vaginal delivery
2. Promote lactation
3. PTx and prevention of post partum hemorrhage

2

Oxytocin
Mechanism

↑SMC: Hormone released during labor by binding to receptor and altering transmembrane ion currents in myometrium.

3

Oxytocin
ADME

Cervical ripening must happen first A; nasal spray contract mamry glands

4

Oxytocin
Adverse

Uterine tachysystole (common) Maternal death (rare) Fetal damage/death if cervix is not dilated H2O toxicity/HoNa+

5

Misoprostal
Indications

1. Induce labor
2. Post partum hemorrhage prevention
3. Induce contrxns post missed or incomp miscarriage in early preg

6

Misoprostal
Mechanism

Prostaglandins
↑SMC

7

Misoprostal
Adverse

1. Bleeding
2. GI SM contrxn: NV&D

8

Misoprostal
Contraindications

Previous cesarean

9

Methylergotamine (Ergot alkaloids)
Indication

1. Post partum hemorrhage prevention 2. Prolonged uterin contrxn post D&C

10

Methylergotamine
Mechanism

↑SMC: partial agonist/antagonist at α-adrenegergic, DA & 5-HT receptors 2. Vasoconstrictive: ↑uterine motor activity, hi doses →sustained contrxn

11

Methylergotamine
ADME

Combo w/ oxytocin

12

Methylergotamine
Adverse

1. Elevated BP 2. N&V

13

Methylergotamine
Contraindications

Many… 1. HTN

14

Tocolytic Agents
Indication

1. Anti-contraction: tocolysis 2. Used to delay preterm delivery for admin of CWS for fetal lung development

15

Tocolytic Agents
Mechanism

↓SMC

16

Tocolytic Agents
Drug List

1. MgSO4 2. Terbutaline; β2 Agonist 3. Ca2+ channel blockers (Nifedipine 4. NSAIDS: Indomethacin 5. Oxytocin receptor antagonists (Atosiban 6. NO inducers

17

Magnesium Sulfate
Indications

Seizure prevention & preeclampsia

18

Magnesium Sulfate
Mechanism

Ca2+ Channel block: ↓ Freq/strength of contrxns

19

Magnesium Sulfate
Adverse

1. Hypermagnesemia: monotor blood 2. Pulmonary edema

20

Terbutaline
Indications

1. Relaxes uterine muscle 2. Prolongs delivery for CS admin (24-48H)

21

Terbutaline
Mechanism

β2 agonist: inactivates myosin light chain kinase

22

Terbutaline
Adverse

1. Adverse effects to mom and baby limit use 2. Reflex tachycardia, hi doses lead to β1 effects 2. HoTN