Exam Review-quick

Question 1

WHich type of anemia has a HIGH TIBC?

Answer 1

Iron deficient

Question 2

What type of anemia has normal or high ferritin, high ESR/CRP?

Answer 2

Anemia of chronic disease

Question 3

Number one cause of Fe deficient anemia

Answer 3

Bleeding

Question 4

Patho of anemia of chronic diseasE?

Answer 4

Increased IL-6, increased hepcidin, Fe stuck in liver and cant get out to serum

Question 5

What types of cells are seen in alpha thalassemia?

Answer 5

HEINZ BODIES, target cells

Question 6

What is the treatment for alpha thalassemia? And beta

Answer 6

Splenectomy, SCT, iron chelation, transfusions, folic acid supplements

Question 7

What are the types of cells seen in beta thalassemia?

Answer 7

Dacrocytes, basophilic stippling, poikilocytosis

Also see target cells

Question 8

Which type of anemia has DECREASED TIBC?

Answer 8

Sideroblastic

Question 9

What types of cells are seen on sideroblastic anemia?

Answer 9

Pappenheimer bodies

Question 10

What two drugs can cause sideroblastic anemia?

Answer 10

Chloramphenicol and linezolid

Question 11

What type of anemia has abnormal spectrin and ankyrin?

Answer 11

Hereditary spherocytosis

Question 12

What type of anemia has deficient CD55 and CD59 proteins?

Answer 12

PNH

Question 13

Which type of anemia has episodic hemoglobinuria, thrombosis?

Answer 13

PNH

Question 14

What is the treatment for PNH?

Answer 14

Eculizumab and corticosteroids

Question 15

Which type of anemia has bite cells, blister cells, and Heinza bodies?

Answer 15

G6PD Deficiency

Question 16

What drugs do you need to stay away from with G6PD?

Answer 16

Dapsone, Nitro, Bactrim, fava beans too

Question 17

What are some lab results for AIHA?

Answer 17

Sphrerocytes, NRBCs, + Coombs test, reticulocytosis

Question 18

Patho of AIHA?

Answer 18

IgG “warm” bind to RBCs

Question 19

What do you use to treat AIHA?

Answer 19

Prednisone

Question 20

What will labs show for cold Agglutinin?

Answer 20

Coombs + for IgM complement only, reticulocytosis, + cold Agglutinin titer

Question 21

What are the treatments for cold Agglutinin?

Answer 21

Avoid cold, Rituximab

Question 22

Rituximab

Answer 22

Treatment for cold Agglutinin

Question 23

Eculizumab

Answer 23

Treatment for PNH

Question 24

Howell-jolly bodies

Answer 24

Sickle cell anemia

Question 25

Substitute valine for glutamic acid in 6th AA

Answer 25

Sickle cell anemia

Question 26

Increased HbS?

Answer 26

Sickle cell anemia

Question 27

What is the treatment for sickle cell?

Answer 27

Hydroxyurea and omega-3 fatty acids, allergenic SCT with HLA matched donor

Question 28

Injury to pluripotent stem cell

Answer 28

Aplastic anemia

Question 29

What are some lab results for aplastic anemia?

Answer 29

Pancytopenia, nor abnormal hematopoietic cells, hypocellular bone marrow

Question 30

Moderate aplastic anemia

Answer 30

<30% cellularity, 2/3 blood elements decreased

Question 31

Severe aplastic anemia

Answer 31

<25% cellularity, retics <40,000 neutrophils <500 platelets <200

Question 32

Very severe aplastic anemia?

Answer 32

Same as severe except neutrophils <200

Question 33

VitB12 deficiency lab smear

Answer 33

Macroovalocytes, hypersegmented neutrophils, high MMA and homocysteine

Question 34

VitB12 si/sx

Answer 34

NEURO issues: decreased vibration, proprioception, memory issues

Question 35

Folic acid deficiency happens in who?

Answer 35

Alcoholics

Question 36

Smear for folic acid deficiency?

Answer 36

Megaloblastic smear, macroovalocytes and hypersegmented neutrophils, high homocysteine