Exam1- Serology Flashcards Preview

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Flashcards in Exam1- Serology Deck (25)
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1
Q

fecal oral route**, travelers, MSM, IV drugs, daycare

A

Hep A

2
Q

Hep A
jaundice w/in?
Sx: fatigue, N/V, RUQ pain
serology?

A

2 weeks

IgM anti-HAV Ab

3
Q

Hep A, B, and AI Hep» ALT & AST?

A

10-100x

4
Q

Hep B Serology

  1. needed for acute or chronic infix?
  2. right before Sx?
  3. acute infx?
  4. window period- between ? and ?; will find?
  5. resolved infx?
A
  1. HBsAg (surface Ag)- first found
  2. IgM anti-HBc Ab
  3. HBsAg & IgM anti-HBc Ab
  4. HBsAg & HbsAb; will detect IgM anti-HBc Ab
  5. Core Total Ab (HBc total) & HepBsAb
5
Q

Hep C
MC from?
positive ? test must be confirmed w/?

A

blood (IV drug users very common too)

HCV Ab, qualitative HCV RNA

6
Q

HIV
screen w/ ? and confirm w/ ?
2/3 antibodies must be detected:

A

ELISA, western blot

p24, gp41, gp120

7
Q

HIV- indeterminate western blot

  • characterized by?
  • causes: partial seroconversion, HIV2, autoAb
  • repeat in ? w/ ?
A

only one band

3 months, HIV-RNA

8
Q

EBV

-nonspecific test? detects?

A

monospot (rapid); heterophile Ab (bind to surface of RBCs from cows, horses, etc)

9
Q

negative monospot:

  • too early
  • decreased sensitivity in ?
  • mono-like Sx from ?
A

young children

CMV

10
Q

EBV

SPECIFIC test? (viral capsid Ag)

A

IgM anti- VCA

11
Q

syphilis:

primary: ? at site of contact
secondary: rash on ? and ?
tertiary: thoracic aortic aneurysm, aortic valve insufficiency, and ?

A

chancre
palms, soles
neurosyphilis

12
Q
  • syphilis tests?

- confirmation/specific?

A
  • VDRL, RPR&raquo_space; Non-treponomal, SEMI QUANTITATIVE

- fluorescent treponemal Ab absorption (FTA-Abs), Treponema Pallidum Particle Agglutination (TP-PA)

13
Q
B hemolytic strep group A
initial test?
if negative?
if also negative?
FINALLY if also negative?
A

rapid strep
throat culture
return in 2-4w for an ASO (post strep rheumatic fever & glomerulonephritis)
Anti-DNAse B (post strep glomerulonephritis only)

14
Q
SLE:
95% sensitive?
specific tests? (2)
nonspecific lupus anticoagulant aka?
can see a false positive ?
A

ANA
Smith’s, (anti-sm), anti-dsDNA
antiphospholipid Ab
VDRL (syphilis)

15
Q

“grain of sand in eye”?
female ~40-60
serology?

A

sjogren’s syndrome

anti-SS-A, anti-SS-B

16
Q

“rubber hose esophagus”, “pursed mouth”
female ~ 40
serology?

A

scleroderma (diffuse*)

anti-Scl-70

17
Q
CREST syndrome (scleroderma- limited)
serology?
A

anti-centromere antibody

18
Q
  • mixed Sx of SLE, RA, polymyositis, scleroderma?

- serology?; ANA w/ ? pattern

A

RNP; speckled

19
Q

RA arthritis serology?

A

CCP (95% specific)

20
Q

polymyositis/dermatomyositis serology?

A

muscle Bx and CK

21
Q

pernicious anemia serology?

A

anti-parietal cell Ab, anti-intrinsic factor Ab

22
Q

primary biliary cirrhosis:

  • serology?
  • labs consistent w/ ?
  • fatigue, pruritis
  • increased ALP >2
  • Dx?
A

anti-mitochondrial Ab
cholestasis
Liver Bx

23
Q

autoimmune hep

  • unknown origin
  • serology?
  • diagnosis?
  • associated with hemolytic anemia, thyroiditis
  • may cause ? or progress to ?
A

ANA, **anti- smooth muscle Ab, liver Bx
Dx of exclusion
fulminant hep, cirrhosis

24
Q

Myasthenia Gravis

-serology?

A

anti-ach receptor Ab

anti-musk Ab (for people negative for anti-AchR)

25
Q

rapid HIV uses:

A

labor
occupational- getting sticked at work
clinic- IV users