Flashcards in Exam2 Deck (125)
Where do T Cells mature?
What are the "antibody-like" receptors found on T Cell surface?
T Cell Receptor (TCR)
What MHC do killer T cells scan?
MHC 1 presented by all cells
MHC 2 are scanned by what cells?
Helper T cells
Helper T Cells secrete what 2 cytokines?
What are the three antigen presenting cells that helper t cells need for activation?
Dendritic cells, Macrophages, B Cells
What happens if the TCR recognizes the cognate antigen on MHC but isn't co-stimulated?
The T-Cell is anergized (inactivated)
T/F: There are thousands of different TCR's on a given mature T-Cell
False: all TCR on a given T Cell are identical
What are the two types of TCR?
alpha-beta (traditional and most common)
Where are T-cells with gamma-delta TCR most common?
Intestine, uterus, tongue
What is the co-stimulatory molecule found on the T-Cell?
What does the CD28 on a T-Cell bind to?
B7 molecule on APC
What is the group of proteins needed for signaling?
T/F: CD8 is the co receptor found on killer T-cells
What is the function of cholesterol lipid rafts?
Contain large # of signaling molecules, making signaling process easier
T/F: Naïve T-cells have more lipid rafts
False: more experience=more rafts
How many dendritic cells does one helper t-cell scan per hour?
1000 dendritic cells
What does the CD40L and CD40 binding lead to?
Lengthens the life of the dendritic cell involved
How long does the complete activation of a helper T-cell take?
What receptor is absent from naïve T-cell surface?
What are the two jobs of T-helper cell?
1) Stay in blood/lymph to help B-Cells and Killer T Cells
2) Enter battle sites to help reactivate other cells there
What do T-helpers secrete as a form of help?
What are the three major types of T-helper cells?
Th1, Th2, Th17
TLR4 recognizes which 2 pathogens?
Gram-negative bacteria, viruses
TLR3 recognizes what?
double stranded RNA
Gram-positive bacteria are recognized by what toll-like-receptor?
Th1 Helper T Cells are needed in what kind of attack?
Th1=viral or bacterial attack
T/F: Th2 Helper T Cells are needed in parasitic attacks
True: Th2=parasitic/food-borne bacteria
What are the classical cytokines put off by Th1?
TNF, INF-gamma, IL2