Exam3-L30/31- Lipid metabolism Flashcards
(31 cards)
What are the 3 services in a fasted state?
What is the big picture for adipose/ muscle/ liver in a fasted state?
What is the when/where/what/why for lipolysis? What is the rate limiting enzyme? What are the products and their fates? How many fatty acids are typically liberated?
What turns hormone sensitive lipase on/off? What inhibits HSL?
Q1-D/B
How are FFA’s released from adipose carried in the blood? How do they enter cells? How are fatty acids activated?
What is the when/where/what/why of beta oxidation? What is the rate limiting enzyme? What are the products and their fates?
How is CPT-1 transported? CPT2? What is an allosteric inhibitor of CPT1?
What does beta oxidation do to the fatty acyl chain? What are the products? What are their fates? What happens with odd-chain fatty acids? What does the last step do? What happens to Propionyl-Coa?
Q1-A/C
What is the when/where/what/why of ketogenesis? What is the rate limiting enzyme? What are the products and their fates?
Rate limiting enzyme of ketogenesis- what is the starting substrate? What happens to the TCA cycle in the fasted state? What is the RLE controlled by?
Ketone oxidation (ketolysis) in extrahepatic tissues- What does the liver do with ketones? What do untreated diabetics display? What is the domino effect of the fasting state?
What is Jamaican vomiting sickness?
Q3:
Q4:
Q5:
Describe a summary for Lipolysis, Beta oxidation, and ketogenesis.
What is the what/why/when/where/who/how of lipogenesis?
What is the big picture of de novo FA synthesis and TAG synthesis?
De novo FA synthesis- What happens with Acetyl-CoA?
De novo FA synthesis- In the fed state what drives the movement of citrate from the mitochondria to the cytoplasm? How is it sustained?
Stage 1- what does ATP citrate lyase do? how is it regulated? What is ACC?
What are the first 2 ways ACC is regulated?
What is the 3rd way ACC is regulated?
What is fatty acid synthase? What is the reaction? What does Malonyl-CoA contribute?
