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1
Q

Aspirin inhibits which of the following: *
1/1
Fibrinogen
Phospholipase
GP IIB/IIIA
Cyclooxygenase

A

Cyclooxygenase

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2
Q

I. ADP III. Collagen II. Epinephrine IV. Ca2+ Which of the following will activate
Phospholipases to metabolize phospholipids to arachidonic acid to be utilized
in the cyclooxygenase pathway? *
1/1
I and II
II and III
I And IV
III and IV

A

II and III

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3
Q

Hydrolysis of Phospholipids is an important mechanism that occurs on which
phase of the Primary Hemostasis? *
1/1
Vasoconstriction
Secretion
Adhesion
Aggregation

A

Aggregation

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4
Q

Platelet poor plasma is used in coagulation studies. The platelet concentration
0/1
per uL is: *
15,000
20,000
10,000
5,000

A

15,000

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5
Q

Which Marker is carried by Megakaryocyte Progenitor cells? *
1/1
CD34
CD4
CD42
CD8

A

CD34

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6
Q

COVID 19 Pneumonia is associated with deactivation of the Coagulation
Cascade *
1/1
True
False

A

False

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7
Q

All of the following are functions of the Endothelial cells except: *
Production of Fibrinogen
Site of Platelet adhesion during coagulation process
Triggers immune response
Regulation of Vascular tone

A

Production of Fibrinogen

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8
Q

Reticulated Platelets are said to be/have: *
1/1
Mature Platelets with Increased Mean Cell Volume
have Residual tRNA
Both
Neither

A

Neither

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9
Q

The non granular area of the platelet is referred to as which of the following? *
1/1
Hyalomere
Centromere
Glycocalyx
Chromomere

A

Hyalomere

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10
Q

I. TPO III. IL 6 II. IL 3 IV. IL 11 Which of the following hormone or cytokine is
being needed in the Megakaryocyte Differentiation Phase? *
B. I, II and III
D. I and IV
C. I, II and IV
A. I, and III

A

C. I, II and IV

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11
Q

2/3 of the Platelet population is found in the circulation.
*
True
False

A

True

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12
Q

Function of vwf, Except *
May Bind to GP IIB/IIIa
Promote Adhesion
None
Carrier of Factor VII

A

Carrier of Factor VII

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13
Q

Most Coagulation studies are carried out by which of the following? *
Clotted Sample
Contact surface
Room Temperature
Body Temperature

A

Body Temperature

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14
Q

Ratio of Anticoagulant to blood for coagulation studies is: *
9:1
9:2
1:1
1:9

A

1:9

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15
Q

Platelet poor plasma can be stored for several weeks if put at what
temperature? *
1/1
Room Temperature
37 C
-40 C
-10 C

A

-40 C

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16
Q

Thromboxane A2 causes all of the following Except: *
1/1
Adhesion
Aggregation
None
Secretion

A

Adhesion

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17
Q

Based on your reflection paper, Monitoring of Heparin in COVID 19 patients is
associated with increased results of: *
1/1
Platelet Count
PT
APTT
Fibrinogen

A

APTT

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18
Q

Thrombin is a vasodilator and platelet stimulating Agent.
*
1/1
True
False

A

True

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19
Q

Adhesion is: *
1/1
Reversible
Irreversible
Both
None

A

Reversible

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20
Q

All of the following is a source of Von Willebrand Factor Except: *
0/1
None
Alpha Granules
Plasma
Endothelium

A

none

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21
Q

Aspirin like defects is under which category of hereditary function defects? *
0/1
Adhesion defects
Aggregation defects
Severe coagulation Factor deficiency
All options

A

Aggregation defects

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22
Q

Aspirin like defects is under which category of hereditary function defects? *
0/1
Adhesion defects
Aggregation defects
Severe coagulation Factor deficiency
All options

A

Aggregation defects

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23
Q

Endomitosis/Endoreduplication is a type of cell division without the
Metaphase.
*
0/1
True
False

A

False

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24
Q

I. TPO III. IL 6 II. IL 3 IV. IL 11 Which of the following hormone or cytokine is
being needed in the Progenitor Differentiation Phase? *
0/1
II and III
I, and II
I , II and IV
I, and III

A

I, and II

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25
Which of the following is a a cofactor of protein C * 1/1 Heparin Sulfate Thrombomodulin t-PA Collagen
Thrombomodulin
26
Serine Protease Inhibitors act in which of the following? * 0/1 Primary Hemostasis Secondary Hemostasis Fibrinolysis Both 1st and 2nd Option
Secondary Hemostasis
27
Platelet Factor 4 acts as which of the following: * Fibrin former Heparin Inhibitor Chemotactic Platelet spreading
Heparin Inhibitor
28
A platelet count of 93, 000/ mm3 is most likely to result to: * Hemolysis Thrombosis Bleeding Normal Function
Bleeding
29
Adhesion of platelets is due to the decrease of which of the following? * Prostacyclin Serotonin Nitric Oxide Collagen
Prostacyclin
30
Vasoconstriction is a mechanism that is due to which of the following? * 1/1 Increased Prostacyclin Increased Sympathetic response Both None
Increased Sympathetic response
31
Sodium citrate recommended for coagulation studies: * 1/1 0.109 M 0.129 M Both Neither
0.109 M
32
Abnormal Increased activity of Inhibitors will result to which of the following? 0/1 * Bleeding Clotting Balance All options
Bleeding
33
The coagulation specimen should be centrifuged within: 0/1 Both Neither 2 hours 4 hour
Neither
34
Platelet Secretion is due to which of the following? * 1/1 Thrombasthenin vWF Tubulin Serotonin
Tubulin
35
The Microtubule is composed of Actin and Myosin. * 1/1 True False
False
36
Refers to invagination of the plasma membrane for release of granule content during platelet activation process. * 0/1 Open Canalicular System Surface Connecting System Dense Tubular System Both A and B
Both A and B
37
Which of the following is a characteristic of a normal inactive platelet? * 0/1 Granular Appears gray in wright stained smears Spherical in shape Multi nucleated
Granular
38
The protein thrombosthenin necessary for Clot retraction is a composed of which of the following? * A. Actin B. Myosin C. Tubulin D. Both A and B
Both A and B
39
I. ADP III. Serotonin II. Fibrinogen IV. vWf Which of the following is secreted by the Alpha granules of the platelets? * II and III I, II and IV I and II I only
I, II and IV
40
Associated with Platelet Secretion: * 1/1 Open Canalicular System Microfilaments Both Neither
Open Canalicular System
41
Citrate Tubes for Coagulation test should follow which Tube in the order of Draws: * EDTA Tube Heparin Tube SPS Tube Fluoride Tube
SPS Tube
42
Which of the following is being secreted by alpha granules? * 1/1 Serotonin ADP Magnesium Ion Platelet growth Factor
Platelet growth Factor
43
Binding of Fibrinogen to GP IIb/ IIIa is stimulated by which of the following? * 1/1 Prostacyclin Thromboxane A2 Calcium ADP
Calcium
44
Megakaryoblasts carry CD42. * 1/1 True False
True
45
I. Megakaryoblast III. Promegakaryocyte II. Granular Megakaryocyte IV. Mature 0/1 Megakarocyte. At which of the following stages are nucleoli seen? * II and III I and III I, II, and III I and II
I and III
46
Coagulation factor that is activated by the cold: * 0/1 V VIII VII IV
VII
47
Protein component necessary for the maintenance of Platelet shape: * Actomyosin Collagen Tubulin Thrombasthenin
Tubulin
48
Attachment of Platelet with each other is referred to as? * 1/1 Platelet Adhesion Platelet Aggregation Platelet Activation Platelet Secretion
Platelet Aggregation
49
What occurs during platelet Adhesion? * 1/1 Release of Thromboxane A2 Binding of GP IIb/ IIIa with Fibrinogen Binding of GP ib with vWf Shape change of Platelet
Binding of GP ib with vWf
50
Responsible for platelet aggregation * 1/1 GP IB Prostacyclin TXA2 vwF
TXA2
51
Bleeding Time is used to evaluate the activity of: * 1/1 Platelets Prothrombin' Factor XIII Labile Factor
Platelets
52
Which of the following test results is normal in a patient with classic von Willebrand's disease? * 1/1 APTT Bleeding Time Platelet Count VWF Level
Platelet Count
53
No bleeding is observed in deficiency of which of the following factors? * 1/1 A. II B. XII C. IX D. VIII
XII
54
Hemolytic Uremic syndrome is associated with: 1/1 Fever and thrombocytosis Granulocytosis E. coli Leukocytosis
E. coli
55
Coagulation Factors affected by Coumarin Drugs: * 1/1 VIII, IX, and X I, II, V and VII II, VII, IX and X II, V, and VII
II, VII, IX and X
56
Thrombotic thrombocytopenic prpura is characterized by: * 1/1 Prolonged PT Increased platelet aggregation thrombocytosis prolonged Aptt
Increased platelet aggregation
57
A protein that plays a vital role in both coagulation and platelet aggregation: 1/1 I XI VIII IX
I
58
The defect characterizing Gray's Syndrome: * 1/1 Platelet Adhesion Dense Granule Alpha Granule Coagulation defect
Alpha Granule
59
Factor XIII is activated by which factor? * 1/1 IIa Va Xa Fibrinogen
IIa
60
Factor V is a cofactor to factor X to activate factor II * 1/1 True False
True
61
What clotting factors are inhibited by Protein S? 1/1 V and X V and VIII VIII and IX VIII and X
V and VIII
62
What is the second phase of secondary Hemostasis? * 1/1 Contact Phase Activation of factor VII Activation of factor X Formation of Fibrin Clot
Activation of factor X
63
Several hours after birth, a baby boy develops petechiae and a hemorrhagic diathesis. Platelet count i8,000/uL. What is likely the explanation? 1/1 Drug induced thrombocytopenia Secondary Thrombocytopenia Isoimmune Neonatal Thrombocytopenia Neonatal DIC
Isoimmune Neonatal Thrombocytopenia
64
When performing platelet aggregation studies, whcich is most likely associated with Bernard Soulier Syndrome: * 1/1 Decreased with ADP Normal to Epinephrine, Decreased to Ristocetin Normal to Epinephrine and Ristocetin, decreased with collagen Normal to Collagen, ADP and Ristocetin
Normal to Epinephrine, Decreased to Ristocetin
65
Factor XIII is a serine protease * 1/1 True False
False
65
Which of the following is a chracteristic of acute idiopathic thrombocytopenic purpura? * Insidious onset Spontaneous remission within a few weeks Predominantly seen in adults Nonimmune platelet destruction
Spontaneous remission within a few weeks
66
Which of the following Inhibitors inhibit Factor IIa? * A. Protein C Antithrombin III Both Neither
Both
67
Which of the following is correct regarding acquired thrombotic thrombocytopenic purpura? Autoimmune Disease Decreased VWF Decreased Platelet Aggregation Decreased Platelet Adhesion
Autoimmune Disease
68
TAFI target protein: * TFPI Fibrinogen Fibrin VwF
Fibrin
69
Which step requires calcium? Factor VII activation Factor XII activation Factor XIII activation Factor I activation
Factor XIII activation
70
Giant platelet is associated with which condition: * Bernard Soulier Syndrome Glanzmann's Thrombasthenia Gaucher's Disease All of the choices
Bernard Soulier Syndrome
71
Platelet abnormality will affect Both Bleeding Time and Clotting Time True False
True
72
Which of the following is associated with post transfusion purpura? * Nonimmune thrombocytopenia/ alloantibodies Immune mediated thrombocytopenia/ Alloantibodies Both of the above Autoantibodies
Immune mediated thrombocytopenia/ Alloantibodies
73
Thiazide diuretics results to: Decreased Platelet Production Decreased Platelet survival Both Neither
Decreased Platelet Production
74
Which of the Following Factors is used only in the Extrinsic Coagulation Pathway? * II VII V VIII
VII
75
Hereditary hemorrhagic telangectasia is a disorder of: * Platelets Clotting proteins Fibrinolysis Connective tissue
Connective tissue
76
Which of the following coagulation factors is considered to be labile? * II III V VII
V
77
What role does vitamin K play in the Prothrombin group? * A. Provides surface on which thr proteolytic reaction occurs B. Protects them from inapprpriate activation by compounds such as thrombin C. Accelerates the binding of the serine protease and their cofactors D. Carboxylates the factors to allow calcium binding
D. Carboxylates the factors to allow calcium binding
78
Factor I deficiency will affect APTT and PT * True False
True
79
Aspirin prevents platelet aggregation by inhibiting the action of which enzyme? * Prostacyclin Synthase Phospholipase Cyclooxygenase TXA2 Synthase
Cyclooxygenase
80
Which statement regarding protein C is correct? * Vitamin K independed Fibrinogen activated activates V and VIII Activity is enhanced by Protein S
Activity is enhanced by Protein S
81
Thrombocytopenia may be associated with * Postsplenectomy Myeloproliferation Hypersplenism Acute Blood loss
Hypersplenism
82
The APTT is sensitive to adeficiency of which clotting factor? * Calcium X Both None
None
83
Which of the following factors will activate factor XI? * A. Stuart Factor B. Fibrinogen Hageman Factor Plasma Thromboplastin Antecedent
Hageman Factor
84
Lumi-aggregation measures: * 1/1 Platelet aggregation Aggregation and ATP release Platelet Adhesion GP 1B
Aggregation and ATP release
85
APTT is used to? * 0/1 A. Monitor Heparin Therapy B. Evaluate the Common Pathway Both None
Both
86
Neurologic findings may be commonly associated with which of the following 1/1 disorders? HUS TTP ITP PTP
TTP
87
True of TTP and DIC: * APTT prolonged in DIC Schistocytes are present in DIC Platelet is decreased in TTP PT is decreased in DIC
APTT prolonged in DIC
88
Which of the following tests is most likely to be abnormal in patients taking Aspirin? * Platelet morphology Platelet Count Bleeding Time Prothrombin Time
Bleeding Time
89
Platelet aggregation response for Glannzmann's Thrombasthenia: * Normal to ADP , decreased to ristocetin Normal to Ristocetin, Decreased to Epinephrine Normal aggregation to collagen, Decreased to ADP and Ristocetin Normal to ADP and Ristocetin, decreased to Collagen
Normal to Ristocetin, Decreased to Epinephrine
90
Thrombin-Thrombomodulin complex is necessay for the activation of: 1/1 Protein C Antithrombin protein S Factor V and VIII
Protein C
91
Scott Syndrome will affect which of the following? * 0/1 Platelet Adhesion Vasoconstriction Secondary Hemostasis Fibrinolysis
Secondary Hemostasis
92
Citrated plasma for APTT and PT testing should be centrifuged at 2500 x g for a. 5 min b. 15 min c. 10 min d. 20 min
b. 15 min
93
Which of the following factor will be decreased in cases of Vitamin K deficiency? I. Christmas Factor II. Proconvertin III. Stuart Factor IV. Hageman Factor a. II and III b. I, II and III c. I and IV d. I, II and IV
I, II and III
94
Von willebrand Disease a. c. Both PT and APTT Normal b. PT Prolonged, APTT Normal Both PT and APTT Prolonged d. PT Normal, APTT Prolonged
d. PT Normal, APTT Prolonged
95
Factor XIII Deficiency a. PT and PT Normal b. PT Prolonged, APTT Normal c. PT Normal, APTT Prolonged d. Both PT and APTT Prolonged
PT and PT Normal

hema lec 2 (2 decks)

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