Excretion SWYK reflection - M5

Question 1

What symptoms would you expect with someone who doesn’t respond to ADH

why

Answer 1

-High volume of urine, Always thirsty

Because fewer aquaporins in the membrane of the collecting duct

Question 2

which characteristics should be taken into account when using GFR measurement to diagnose kidney damage?

GFR measures creatinine= formed from a breakdown of creatinine phosphate in the muscles

Answer 2

-Diet, affect level of creatinine

-Gender, men typically have more muscle

Question 3

During detoxification , paracetamol is metabolised in the liver as follows :
-5% oxidesed by P450 enzyme system which produces NAPQI
-NAPQI is then metabolised using another component called glutathione

Suggest reasons for accumilation of high concentrations of NAPQI in the liver cells

Answer 3

-NOT enough glutathione
-enzyme catalysing glutathione reaction is at V max
-NAPQI can’t cross cell membrane