Extension of Ppt 6 Complement Flashcards Preview

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Flashcards in Extension of Ppt 6 Complement Deck (37):
1

What is C3b used for?

opsonization of microbes

2

who recognizes C3b in phagocytes?

C1 receptor

3

What other complement molecule is recognized with C1 receptor in phagocytes?

C4b

4

what other complement molecule works as an opsonin?

C4b

5

what does the MAC (membrane attack complex) do to microbes?

it creates pores in their membranes

6

what are C3a, C4a and C5a?

anaphylatoxins

7

what do anaphylatoxins do?

they cause smooth muscle contraction and histamine release from mast cells

8

what complement pathway is activated by C3b?

the alternate pathway

9

how do you start the classical pathway of complement? (binding what?)

you bind C1 to microbe

10

what happens with complement if you bind a lectin to a microbe?

you start the Mannose binding lectin pathway

11

what do all pathways have in common?

they all create the MAC complex and all lead to C3b

12

what happens to C3 in plasma during the alternative pathway?

C3 gets hydrolized and forms C3b that binds to antigen

13

In alternative pathway, fluid C3b will do what? by binding to whom?

bind to antigen, especially to Factor Bb

14

When C3b binds to Factor Bb in the alternative pathway, what will be created?

C3 convertase

15

what does the C3 convertase in alternative pathway do?

cleave more C3 to C3b

16

In the alternative pathway, more C3b created will do what?

bind more and more to the microbe surface

17

in the alternative pathway, when many C3b are bound to the Factor Bb, what is formed?

C5 convertase

18

in the alternative pathway, what will C5 convertase do?

it will cleave C5 into C5b

19

what does C5b initiate in the alternative pathway of complement?

it begins the late phase of complement

20

how is the classical pathway of complement initiated?

by binding of C1 to the antibodies bound on microbe

21

in the classical pathway of complement, what binds to the C1 protein? what happens after it binds?

C4 binds to C1 and C1 cleaves it to C4b

22

In the classical pathway of complement, what will C4b do after it is cleaved by C1?

C4b will bind to microbe surface

23

In the classical pathway of complement, what will happens after C4b binds to microbe and to the antibodies bound to microbe?

C2 binds to C4b and gets cleaved forming the complex C4b + C2a

24

In the classical pathway of complement, what is another name for the complex C4b + C2a?

C3 convertase

25

In the classical pathway of complement, what will the C4b + C2a complex do in the microbial surface?

it will cleave C3 into C3b

26

In the classical pathway of complement, what will happen to the C3b produced by the C3 convertase (C4b+C2a complex)?

C3b binds to microbe surface and to the C3 convertase

27

In the classical pathway of complement, when the C3b binds to C3 convertase, what gets formed?

the C5 convertase

28

when does the late phase of compliment start?

when C5 convertase is formed

29

what does the late phase involve?

cell lysis (MAC) and inflammation (C5a)

30

what does DAF do to the alternate pathway of complement?

it removes the Factor Bb off the C3 convertase

31

what does DAF do to the classical pathway of complement?

it will remove C4b off the C3 convertase

32

what does the C1 inhibitor do?

blocks attachment of C1, so classical pathway of complement cant proceed

33

What does C1R do in the alternate pathway of complement?

it removes Factor Bb preventing the formation of C3 convertase

34

What does C1R do in the classical pathway of complement?

it removes C4b preventing formation of C3 convertase

35

deficiency of C9 leads to profound infection by who?

Nisseria

36

C2 and C4 deficiency leads to infections resembling what disease?

SLE

37

what type of disease do C3 deficient ppl develop?

autoimmune