extras Flashcards
what do inverse agonists do?
reduce constitutive activity at receptor (ability to fire without ligand)
What are spare receptors?
full respone without activating all receptors
rate limiting step of glycolytic pathway?
phosphofructokinase
where does poplieal artery begin?
adductor hiatus
what happens to resistance if two vessels are linked?
total rsistance is less that resistence of either vessel alone
what is reversible ischaemic injury characteised by?
K efflux from cells due to sodium pump failure
What do subcostal muscles do?
aid with expiration
how does ipratropium work in asmtha
blocks smooth muscle contraction
What is the most important mechanism for alteration in drug response?
differences in active transport mechanisms
oral bioavailability diazapam
100%
What drug can cause severe rebound hypertension when stopped
clonidine
what does GTN mainly work on
veins
flecanide class
1c
when should thrombolysis happen
under 3 hours
what causes nutmeg liver?
hypo perfusion
type of mutation in CF
deletions
what virus is molluscum from
pox
what causes acute hiv
cd8 cytotoxic cells
what type of hypersensitivity is transplant rejecion
2
3
4
how does vagal manoevure work on the heart
slows AV conducttion
where is most airway resisnance?
medium sized bronchioles
what happens to RBC in caplillaies
increase in size due to osmosis
what increases turbulence
increased velocity
what causes visceral pain
distension
