Extras: Drugs Flashcards
(30 cards)
which inhaled anesthetic causes hepatitis?
halothane
two inhaled anesthetics that cause renal toxicity
sevoflurane, enflurane
most IV anesthetics act how?
on GABA receptors
how to reverse midazolam
flumazenil
two AEs of propofol
hypotension, anti-emetic
what does dexmedetomidine act on?
a2 adrenergics (agonist)
how are barbiturates and benzos adjuncts to anesthesia?
increase GABA receptor sensitivity/opening
how do local anesthetics work?
block voltage-gated Na channels
three local anesthetics that are the most potent + longest duration
bupivacaine, ropivacaine, tetracaine
which local anesthetic is surface use only bc poor solubility in water?
benzocaine
what does high blood:gas partition coefficient mean?
quicker anesthesia onset
NMJ blockers: non-depolarizing vs depolarizing block: which is succinycholine?
succ = depolarizing blockage
how to reverse non-depol NMJ blockers?
cholinesterase inhibitors
three NMJ blockers that are long-acting
doxacurium, pancuronium, pipercuronium
which spasmolytic is also an anxiolytic?
carisoprodol
two spasmolytics that arent centrally acting
dantrolene, botulinum toxin
MOA of dantrolene and botulinum toxin
- Dantrolene: block Ca release from SR
2. Botulinum: cleave VAMP -> no Ach release
MOA fo glatiramer acetate
similar to myelin basic proteim -> activates T cell suppressors
MOA of INF-B for MS
binds VLA-4 on T cells -> cant bind BBB to enter brain
MOA of Mitoxantrone for MS
intercalates into DNA
translocation seen in Ewing Sarcoma
t(11;12)
only osteoporosis drug that increases bone formation
teriparatide
raloxifene MOA
SERM: selective estrogen receptor modulator
MOA of denosumab for osteoporosis
RANKL inhibitor
