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Flashcards in Factors Deck (12):
1

Factor I - Fibrinogen

Source: Liver
Common pathway; converted to fibrin (insoluble weblike substance of clot)

2

Factor II - Prothrombin

Source: Liver (synthesis requires vit.K)
Common pathway; converted to thrombin (converts fibrinogen to fibrin)

3

Factor III - Tissue Factor

Source: Tissue cells
Activates extrinsic pathway

4

Factor IV - Calcium ions

Source: Plasma
Needed for essentially all stages of coagulation process; always present

5

Factor V - Proaccelerin

Source: Liver, platelets
Common pathway

6

Factor VII - Proconvertin

Source: Liver (synthesis requires vit.K)
Both extrinsic and intrinsic pathways

7

Factor VIII - Antihemophilic factor (AHF)

Source: Liver, lung capillaries
Intrinsic pathway; deficiency results in haemophilia A

8

Factor IX - Plasma thromboplastin component (PTC)

Source: Liver (synthesis requires vit.K)
Intrinsic pathway; deficiency results in hemophilia B

9

Factor X - Stuart factor

Source: Liver (synthesis requires vit.K)
Common pathway

10

Factor XI - Plasma thromboplastin antecedent (PTA)

Source: Liver
Intrinsic pathway; deficiency results in hemophilia C

11

Factor XII - Hageman factor

Source: Liver
Intrinsic pathway; activates plasmin: initiates clotting in vitro; activation initiates inflammation

12

Factor XIII - Fibrin stabilising factor (FSF)

Source: Liver, bone marrow
Cross-links, forming a strong, stable clot