Familial Cancer Syndromes

Question 1

Which one of the following descriptions is not how MYCC gene can be calssified?
A. Germ line mutations in this gene causes a familial cancer syndrome
B. It is a proto-oncogene
C. It is a transcription factor
D. It is implicated in the pathogenesis of a number of lymphoreticular cancers.

Answer 1

A. Germ line mutations in this gene causes a familial cancer syndrome

Question 2

One of the applications of a cDNA microarray anlysis is:
A. to assess alteration in expression profile
B. to determine the sequence of DNA
C. to look for chromosomal aneuploidies
D. to “paint” chromosomes
E. to screen genomic DNA for possible mutations

Answer 2

A. to assess alteration in expression profile

Question 3

Which one of the following breast cancer predisposition genes has the lowest penetrance?
A. ATM
B. BRCA1
C. BRCA2
D. TP53
E. TSC1

Answer 3

A. ATM