Family medicine rotation Flashcards
(184 cards)
Gouty arthritis vs pseudogout?
Gouty arthritis: MSU crystals in joints due to excess uric acid esp in great toe
Pseudogout: Calcium pyrophosphate dehydrate crystals in joints (dx by rod-shaped, rhomboid, WEAKLY birefringence by crystal analysis)
Factors that can induce hyperuricemia/to take into consideration when considering gout attacks?
Men 30-50yo
Women 50-70yo
- Recent increase in alcohol consumption
- Large meal (esp if red meat, liver or seafood since they are high in purines)
- Trauma, surgery
- Recent h/o thiazide diuretic use
Compare calcium pyrophosphate dehydrate vs calcium hydroxyapatite vs calcium oxalate crystals
calcium pyrophosphate dehydrate:
- Rod shaped
- Rhomboid
- Weakly positive birefringence
Calcium oxalate:
- Bipyramidal
- Mostly seen in ESRD pts
- Strongly positive birefringence
Calcium hydroxyapatite:
- Seen by electron microscopy
- Cytoplasmic includions that are NON-birefringent
Gross appearance of joint aspirate is essential/non-essential for diagnosis of septic arthritis. T/F?
FALSE
- Both septic aspirate and a heavily condensed crystal-induced arthritis may have a thick, yellowish/chalky appearance
- *Thus gross appearance of fluid is NOT very specific
- **To dx crystal-induced arthritis you need polarizing microscopy to reveal MSU crystals
How do labs help you distinguish crystal induced arthritis from septic joint?
Crystal induced joint aspirate will have avg 2,000-60,000/uL WBCs with 90% PMNs
DDx for nontraumatic swollen joint?
Gout (or any crystal induced arthritis)
Infectious arthritis
OA
RA
Likely bacteria responsible for joint infections in HIV+ patients? IVDU?
HIV+
- Pneumococcal, salmonella, H. influenzae
IVDU
- Streptococcal, staphylococcal, gram negative, or Pseudomonas
Septic joint will have a very limited ROM. T/F?
True; limited ROM due to pain
*Maintain ROM in cellulitis, bursitis, or osteomyelitis
OA is most commonly seen in people older than ____ years and is associated with ___
>65yo Associated with: - Trauma - Obesity (esp for knee OA) - H/o of repetitive joint use
When is an ultrasound indicated in pregnancy?
Uncertain gestational age Size/date discrepancies Vaginal bleeding Multiple gestations Other high-risk situations
How much radiation is too much for a pregnant woman? Are MRIs safe?
> 5 rad; associated with fetal harm
(e.g. dental x ray is .00017 rad)
Fetus particularly sensitive to radiation during 2-15 weeks after conception
*MRIs are NOT shown to be harmful but not recommended
How much folic acid should women take if they are thinking of getting pregnant?
Should start folic acid supplement at least 1 month prior to attempting to conceive
- Low risk women: 400-800ug daily
- Women who has had child with NT defect: 4mg daily
How do you determine the estimated delivery date? When should you obtain this?
Obtain at initial prenatal visit
- Get history; get first day of last menstrual period (LMP)
- Use Naegele’s rule: from first day of LMP subtract 3 months and add 7 days
- Make sure LMP is reliable:
- Date is certain
- LMP was normal
- No contraceptive use in the past 1 year
- Pt has had no bleeding since LMP
- Regular menses
- **Not reliable LMP? Get ultrasound!
When should you be able to hear heart tones in a fetus?
10 week gestation using handheld doppler fetoscope
Initial lab screen for pregnant women should include which tests?
CBC Blood type Rh status Rubella HIV Hep B surface antigen Rapid plasma reagin UA Urine culture Pap smear Cervical swab for gonorrhea and chlamydia
How often should prenatal visits happen?
Typical protocol:
- Every 4 weeks until 28 weeks gestation
- Every 2 weeks from 28-36 weeks
- Every 1 week from 36 weeks-delivery
Approximate sensitivity and specificity of triple screen? When is it done and what does it screen for? Most common cause of false-positive serum screen?
Triple Screen
- Sensitivity: 65-69%
- Specificity: 93%
Between 15-20 weeks, preferably 16-18 weeks
Screens for:
- Trisomy 18
- Trisomy 21
- Neural tube defects
*Most common cause of false-positive is INCORRECT GESTATIONAL AGE
Risk factors for increased risk of aneuploidy?
- Women older than 35 at delivery if singleton pregnancy (32 if twins)
- Women carrying fetus with major structural anomaly identified by US
- Women with US markers of aneuploidy including increased nuchal thickness
- Women with previously affected pregnancy
- Couples with a known translocation, chromosome inversion, or aneuploidy
- Women with positive maternal serum screen
***Offer prenatal dx by amniocentesis or chorionic villus sampling
Most trisomy 21 fetuses are born to mothers older than 35 at time of delivery. T/F?
FALSE
Trisomy 21 increases with maternal age but 75% of affected fetuses are born to mothers YOUNGER than 35 at time of delivery
When should women be screened for group B strep?
ALL women should be offered GBS screening by vaginorectal culture at 35-37 gestation (swab lower vagina, perineal area, and rectum)
If colonized, treat with IV antibiotics at time of labor or rupture of membranes in order to reduce risk of neonatal GBS infection
At what week gestation should you consider induction of labor to reduce risk of neonatal mortality and morbidity?
42 weeks (twice weekly testing for fetal wellbeing in prolonged pregnancy recommended at 42 week gestation)
Influenza vaccine is safe in any stage of pregnancy. T/F?
True
provided they have no allergy to its components
When do you give RhoGAM to a pregnant woman?
Women who are Rh negative and if antibody screen or indirect Coombs test is negative –> then give RhoGAM at 28 weeks gestation and again at delivery if the baby is confirmed as Rh positive
*RhoGAM is given to prevent isoimmunization
How is failure to thrive defined?
Weight below third or fifth percentile for age
or
Decelerations of growth that have crossed two major growth percentiles in a short period of time