Farmacogenetica

Question 1

Absorbtia medicamentelor este controlata de doua clase de proteine:

Answer 1

Solute carrier( SLC)
ABC( ATP-binding casette)

Question 2

Proteine care transporta medicamente intracel.

Answer 2

SLC

Question 3

Pompe de eflux celular

Answer 3

ABC

Question 4

Proteine ABC exprimate abundent la nivelul:

Answer 4

Enterocite, celule epiteliare renale, epit. Canalicule biliare

Question 5

Familile de proteine ABC

Answer 5

ABCB
ABCC
ABCG

Question 6

Familia ABCB

Answer 6

MDR multiple drug resistance

Question 7

ABCC

Answer 7

MRP multiple drug resistance associated proteins

Question 8

ABCB1

Answer 8

Glicoproteina P

MDR1

Question 9

EXTENSIVE METABOLIZER

Answer 9

individ homozigot normal

alele tip wild type-izoforma enzimatica cu activitate normala

Question 10

Intermediate metabolizer

Answer 10

Heterozigot
O alela wild type- enz normala
O alela mutanta- enz proasta

Question 11

Poor metabolizer

Answer 11

Homozigot mutant/ hetero compus

Question 12

Ultra extensive metabolizer

Answer 12

Mai mult de 2 alele normale

Question 13

Sistem enz principal metab med

Answer 13

P450

Question 14

Reactii de faza 1

Answer 14

Hidroliza oxidare reducere

Question 15

Faza 2 reactii

Answer 15

Conjugare

Question 16

Superfamilia de gene care codifica P450

Answer 16

Gene CYP

Question 17

Isoforma CYP2C9

Answer 17

Polimorfa
Anticoagulante orale 
AntiD orale
Antiepileptic( fenitoina)
AINS

Question 18

CYP2C19

Answer 18

Inhibitori de pompa de H+ ( omeprazol, pantoprazol, lansoprazol…)
Antidepresive-inhibitori recapt. serotonina( fluoxetina)
Antiepileptice
Inhib proteaza HIV
Antimicotice
Antiagregantul plachetar clopidogrel

Question 19

CYP2D6

Answer 19

Antidepressants 
Statine
Analg. Opioide
AntiHTA
Antiestrogenicul TAMOXIFEN

Question 20

Profilaxie cancer de san plus cyp

Answer 20

Tamoxifen

CYP2D6

Question 21

Analogi pirimidinici cancere epit

Answer 21

5 fluorouracil

Capecitabina

Question 22

UGT

Answer 22

Glucuronidare subst. Endobiotice si Xenobiotice

Question 23

UGT1A1

Answer 23

Metab. Bilirubina
Sindr. Gilbert Criegel-Najal 1 2
Important- irinotecan-citostatic

Question 24

NAT2 relatii med

Answer 24

Hidralazina-vasodil.

Isoniazid- tuberculoza

Question 25

Tiopurine(prodroguri)

Answer 25

Imunomodulatoare- boli AI | Citostat-leucemii acute

Question 26

TPMT

Answer 26

Metab tiopurine

Question 27

Primul med. Biologic

Answer 27

``` Imatinib mesylate( gleevec) Inhibitor de tirozin kinaze- BCR-ABL ```

Question 28

Vemurafenibul

Answer 28

Med bio | Asupra cel maligne prot. BARF anormala- melanom metastatic

Question 29

Cetuximab | Pamitumumab

Answer 29

Cancer colo-rectal metastatic AC monoclonali impotriva EGFR Mutatii KRAS=> rezistenta

Question 30

Chimioterap cancer pulm

Answer 30

Molec anti EGFR-erlotinib, geftinib Exceptie cancer pulm cu cel mici Doar la pac. Cu mutatii +egfr

Question 31

Amplificatea genei HER 2 cancer mamar

Answer 31

Tratament transtuzumab- Ac monocl

Question 32

Raspuns anticoag. Orale ( warfarina acenocumarol)

Answer 32

Inr: sex varsta greytate fg Faza 1 CYP2C9 FAZA 2: VKORC1( TINTA LOR VITAMIN K EPOXID REDUCTAZA)