Farmakokinetik Flashcards

(10 cards)

1
Q

Rumus persamaan regresi linear dengan ORDE 0

A

y = bx + a
atau
b = y1-y2 / x1 -x2
ket:
b= slope
a= intercept

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2
Q

Rumus persamaan regresi linear dengan ORDE 1

A

ln y = bx + ln a
atau
b = ln y1 - len y2 / x1 - x2

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3
Q

rumus t1/2 atau waktu paruh pada orde 1

A

t1/2 = 0,693/Kel
ket:
Kel= kecepatan eliminasi

mencari Kel bisa pakai ln y tadi atau rumus t1/2 nya di putar2

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4
Q

rumus loading dosing/ dosis muatan

A

LD= css (mg/L) x Vd
ket:
LD: loading dose
Cp: Targetnya
Vd: Volume distribusi

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5
Q

rumus maintance dose/ laju infus

A

laju infus = css x vd x Kel
ket:
vd = volume distribusi
Kel= kecepatan eliminasi

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6
Q

rumus klirens total

A

Cl= Vd x Kel

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7
Q

rumus waktu paruh (t1/2)

A

t1/2=0,693/Kel

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8
Q

rumus kadar obat dalam plasma darah

A

ln cpt = ln cp0 - k . t
(kalau di tanya t)
t= ln cpt- ln cp0 / k

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9
Q

rumus mencari ED obat pada orde 1

A

Ed = t90
t90 = 0,105/k

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10
Q

rumus auc0-infinity

A

auc0-inf= cp0/kel

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