Fatty Liver Syndrome Flashcards
(15 cards)
1
Q
Fatty liver syndrome characterised by what?
A
massive mobilisation of NEFA
2
Q
Develops when…
A
hepatic uptake of NEFA exceeds oxidation & secretion by liver leading to XS lipids stored as TAG (poor exporters from liver) -> severe fatty infiltrates in liver
3
Q
May have gross
A
liver enlargement
3
Q
Gross PM signs
A
- liver swollen appearance, borders rounded, friable
- pale, swollen, indentations of ribs, rounded edges
4
Q
Accumulation of TAG in liver
A
- decreased liver metabolic fxn -> decreased gluconeogenesis/ureagenesis -> lipogenesis
- increased ammonia/NEFA/ketones (BHB/acetoacetate) -> toxic at high lvls
5
Q
Fat cow syndrome
A
- increased prevalence of milk fever, RFM, mastitis
- delayed uterine involution
- disruption in synthesis of steroidogenic hormones (P4/LH) -> reduced fertility
- decreased insulin & IGF-I
6
Q
Morbidity
A
5-14%
7
Q
Mortality
A
high, esp if clin/neuro signs
8
Q
common in
A
intensive dairy production w/ high BCS at calving or feed restrictions/fasting during last few wks prior to calving to decrease foetal BW
9
Q
Risk factors
A
- mgmt: inadeq space, poor transition diet mgmt, poor silage
- genetics
- age
- winter calving: poor qlty feed; overconditioned in dry period
10
Q
Clin presentation
A
- subclin assoc’d w/ subclin ketosis/prod’n effects
- chronic fat mobilisation following early onset ketosis
- periparturient ketosis - massive fat accumulation (obese, high mortality)
11
Q
Clin signs
A
- inappetence
- weak rumen contractions
- prolonged recumbency
- recurrent ketosis/ketonuria
- hepatic encephalopathy -> aggression b/c toxic ammonia lvls
- secondary dz: HypoCa, LDA, RFM, metritis
12
Q
Dx
A
- Hx, clin signs
- Clin path - Definitive Dx: GGT (chronicity), AST, GLDH
- Liver Bx
- U/S - most reliable, hyperattenuated deep in structure
13
Q
Prognosis
A
Poor
14
Q
Txt
A
Intensive: glucocorticoids, propylene glycol, B vitamins
Insulin (Zn Protamine) 200-300 IU q 12 hrs if clinical
